HIST1H1A and SUZ12

Number of citations of the paper that reports this interaction (PMID 16431907)
16

Data Source:
BioGRID (pull down)

		HIST1H1A	SUZ12
Gene Name		histone cluster 1, H1a	SUZ12 polycomb repressive complex 2 subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Nuclear Chromatin Nuclear Euchromatin	Sex Chromatin Nucleus Nucleoplasm Nucleolus ESC/E(Z) Complex
	Molecular Function	Protein Binding Chromatin DNA Binding	Chromatin Binding RNA Binding Protein Binding Methylated Histone Binding Histone Methyltransferase Activity Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Nucleosome Assembly Spermatogenesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Positive Regulation Of Cell Proliferation Gene Expression Histone Methylation Histone Ubiquitination Regulation Of Gene Expression, Epigenetic Negative Regulation Of Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic
Pathways		DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Cellular Senescence Programmed Cell Death Apoptotic execution phase	Oxidative Stress Induced Senescence Cellular Senescence Epigenetic regulation of gene expression PRC2 methylates histones and DNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		45 interactors: AEBP2 CCNA1 CCNA2 CCNB1 CCND2 CCNE1 CDK1 CDK2 CDK4 CDK6 CDK7 CDKN1B CRP CTCFL EED EHMT2 EP300 EZH2 GADD45A GZMA IRAK4 KAT2B LIMK1 LIMK2 LOX NAP1L4 NASP PARP1 PARP3 PELP1 PKN1 PRDM1 PRKCA PRKCB PRKCD PRKCE PRKCZ PRKDC PTMA RBBP4 SUZ12 TERF1 TERF2IP TLK1 WHSC1L1	15 interactors: AEBP2 CDK19 CDK8 CREB1 CTCF EZH2 HIST1H1A HIST3H3 MED17 MED6 PAXIP1 PJA1 UBE2I USP7 WDR77
Entrez ID		3024	23512
HPRD ID		00820	06949
Ensembl ID		ENSG00000124610	ENSG00000178691
Uniprot IDs		Q02539	A8K1U9 J3QQW9 Q15022
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromosome Organization Cell Cycle Chromatin Organization Chromatin Modification Regulation Of Cell Cycle Organelle Organization Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Protein Modification Process Regulation Of Cellular Protein Metabolic Process Histone Modification Regulation Of Metabolic Process Mitotic Cell Cycle Process Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Regulation Of Phosphorylation Regulation Of Nitrogen Compound Metabolic Process Cellular Protein Metabolic Process G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Protein Phosphorylation Regulation Of Mitotic Cell Cycle Protein Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Division Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Cycle DNA Metabolic Process Cellular Response To Stress Response To Stress Histone Phosphorylation Regulation Of Catalytic Activity Peptidyl-amino Acid Modification Cellular Metabolic Process Regulation Of Cell Cycle Process Phosphorylation Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Cycle Regulation Of Cellular Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression, Epigenetic	Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Chromatin Organization Organelle Organization Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Maintenance Of DNA Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Chromatin Modification Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Nitrogen Compound Metabolic Process Gene Expression Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Cellular Protein Modification Process Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA Metabolic Process DNA-templated Transcription, Initiation Negative Regulation Of Transcription, DNA-templated Regulation Of Histone Acetylation Positive Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Peptidyl-lysine Modification Regulation Of Histone Methylation Cellular Macromolecule Biosynthetic Process DNA Methylation Positive Regulation Of Histone H3-K36 Methylation Positive Regulation Of SUMO Transferase Activity Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Biosynthetic Process
Tagcloud ?			arise border cartilage cooperates craniofacial crest differentiate ectoderm eed embryogenesis expand extensively ezh2 fails h3k27 learnt migrate neural occupancy plate polycomb prc2 repressive slug snail2 specification trimethylation vertebrate xenopus
Tagcloud (Difference) ?			arise border cartilage cooperates craniofacial crest differentiate ectoderm eed embryogenesis expand extensively ezh2 fails h3k27 learnt migrate neural occupancy plate polycomb prc2 repressive slug snail2 specification trimethylation vertebrate xenopus
Tagcloud (Intersection) ?