H1-1 and LIMK2

Number of citations: 0 (PubMedID 8537403)
Data Source: BioGRID (enzymatic study)

		H1-1	LIMK2
Name		H1.1 linker histone, cluster member	LIM domain kinase 2
Structure
GO Annotations	Cellular Component	Chromatin Nucleosome Euchromatin Nucleus Nucleoplasm Chromosome Cell Surface Vesicle	Nucleus Cytoplasm Cis-Golgi Network Centrosome Spindle Cytoskeleton Perinuclear Region Of Cytoplasm Mitotic Spindle
	Molecular Function	DNA Binding Double-stranded DNA Binding Protein Binding Heparin Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Nucleosome Assembly Spermatogenesis Chromosome Condensation Negative Regulation Of DNA Recombination Positive Regulation Of Receptor-mediated Endocytosis	Protein Phosphorylation Spermatogenesis Actin Cytoskeleton Organization Astral Microtubule Organization Establishment Of Vesicle Localization Head Development Cornea Development In Camera-type Eye Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cilium Assembly
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)	EPHB-mediated forward signaling Sema4D induced cell migration and growth-cone collapse RHO GTPases Activate ROCKs
Drugs		None	Fostamatinib
GWAS		No GWAS studies recorded	Eosinophil count ( 27863252 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 ) Fish- and plant-related diet ( 32066663 ) Mean reticulocyte volume ( 32888494 ) Multiple sclerosis ( 31604244 ) Neutrophil percentage of granulocytes ( 27863252 ) Oily fish consumption ( 32066663 ) Paclitaxel-induced neuropathy ( 23776197 ) Pork consumption ( 32066663 ) Red cell distribution width ( 32888494 ) Sum eosinophil basophil counts ( 27863252 ) Type 2 diabetes nephropathy ( 21150874 )
Novel Interactors		None recorded	1 novel interactors: FCGR2A
Interacting Genes		54 interacting genes: AEBP2 APP CCNA1 CCNA2 CCNB1 CCND2 CCNE1 CDK1 CDK11B CDK2 CDK4 CDK5 CDK6 CDK7 CDKN1B CRP CTCFL EED EHMT2 EP300 EZH2 GADD45A GZMA IRAK4 KAT2B LIMK1 LIMK2 LOX NAP1L1 NAP1L4 NASP NSD3 PAK4 PARP1 PARP3 PELP1 PRDM1 PRKCA PRKCB PRKCD PRKCE PRKCZ PRKDC PTMA RBBP4 RPS6KA5 SET SMYD5 SNCA SUZ12 TAF1 TERF1 TERF2IP TLK1	12 interacting genes: CDC42BPA CFL1 FBXO7 GSN H1-1 HIPK3 LIMK1 MBP NF1 PARD3 ROCK1 RPS6KA1
Entrez ID		3024	3985
HPRD ID		00820	03585
Ensembl ID		ENSG00000124610	ENSG00000182541
Uniprot IDs		Q02539	P53671
PDB IDs		9J8O	1X6A 4TPT 5NXD 7QHG 8GI4 8S3X 8WSW
GO Terms Enriched among Interactors		Chromatin Organization Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Chromatin Remodeling Nucleus Protein Kinase Activity Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Nucleobase-containing Compound Metabolic Process Transferase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein Phosphorylation Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Phosphorylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Cell Cycle Phase Transition Regulation Of Cell Cycle Process Negative Regulation Of Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Cellular Response To Stress Cellular Response To Oxygen-containing Compound Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone Binding Positive Regulation Of Macromolecule Metabolic Process Protein Modification Process Response To Stress Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Negative Regulation Of RNA Metabolic Process ESC/E(Z) Complex Regulation Of Cell Cycle Phase Transition Cell Division Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Localization To Chromosome	Lamellipodium Actin Filament-based Process Actin Cytoskeleton Organization Regulation Of Establishment Of Cell Polarity Regulation Of Establishment Or Maintenance Of Cell Polarity Cytoskeleton Organization Protein Serine Kinase Activity Protein Phosphorylation Internode Region Of Axon Phosphorylation Protein Serine/threonine Kinase Activity Regulation Of Cellular Component Organization Rho Protein Signal Transduction Protein Kinase Activity Actin Filament Depolymerization Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Actin Filament Severing Regulation Of Multicellular Organismal Process Myelination Axon Ensheathment Kinase Activity Actomyosin Structure Organization Positive Regulation Of Multicellular Organismal Process Myelination In Peripheral Nervous System Positive Regulation Of Cellular Component Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Cell-matrix Adhesion Cytosol Organelle Organization Regulation Of Proteolysis Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Immune System Process Muscle Cell Migration Positive Regulation Of Cell Growth Positive Regulation Of Focal Adhesion Assembly Regulation Of Cell Development Positive Regulation Of Supramolecular Fiber Organization Negative Regulation Of Apoptotic Process Intracellular Signaling Cassette Fc-gamma Receptor Signaling Pathway Positive Regulation Of Cytoskeleton Organization Regulation Of Multicellular Organismal Development Protein Depolymerization Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death