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H1-1 and CDKN1B
Number of citations of the paper that reports this interaction (PubMedID
11940657
)
55
Data Source:
BioGRID
(enzymatic study)
H1-1
CDKN1B
Description
H1.1 linker histone, cluster member
cyclin dependent kinase inhibitor 1B
Image
GO Annotations
Cellular Component
Chromatin
Nucleosome
Euchromatin
Nucleus
Nucleoplasm
Chromosome
Cell Surface
Vesicle
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Centrosome
Cytosol
Cilium
Cul4A-RING E3 Ubiquitin Ligase Complex
Ciliary Basal Body
Molecular Function
DNA Binding
Double-stranded DNA Binding
Protein Binding
Heparin Binding
Structural Constituent Of Chromatin
Chromatin DNA Binding
Nucleosomal DNA Binding
Protein Kinase Inhibitor Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Protein Kinase Binding
Protein Phosphatase Binding
Cyclin-dependent Protein Kinase Regulator Activity
Cyclin Binding
Ubiquitin Protein Ligase Binding
Protein-containing Complex Binding
Protein-folding Chaperone Binding
Molecular Adaptor Activity
Molecular Function Inhibitor Activity
Ubiquitin Ligase Activator Activity
Biological Process
Nucleosome Assembly
Spermatogenesis
Chromosome Condensation
Negative Regulation Of DNA Recombination
Positive Regulation Of Receptor-mediated Endocytosis
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
Placenta Development
Potassium Ion Transport
Apoptotic Process
Regulation Of Exit From Mitosis
Notch Signaling Pathway
Regulation Of Mitotic Cell Cycle
Heart Development
Sensory Perception Of Sound
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Programmed Cell Death
Negative Regulation Of Cell Growth
DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of Cell Migration
Positive Regulation Of Microtubule Polymerization
Negative Regulation Of Kinase Activity
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of DNA Replication
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Growth
Negative Regulation Of Mitotic Cell Cycle
Autophagic Cell Death
Inner Ear Development
Negative Regulation Of Epithelial Cell Proliferation
Nuclear Export
Regulation Of Cell Cycle
Epithelial Cell Proliferation Involved In Prostate Gland Development
Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Cellular Response To Antibiotic
Cellular Response To Lithium Ion
Cellular Senescence
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Lens Fiber Cell Differentiation
Regulation Of Cell Cycle G1/S Phase Transition
Epithelial Cell Apoptotic Process
Negative Regulation Of Cyclin-dependent Protein Kinase Activity
Negative Regulation Of Epithelial Cell Apoptotic Process
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Cardiac Muscle Tissue Regeneration
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Apoptosis induced DNA fragmentation
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
SCF(Skp2)-mediated degradation of p27/p21
AKT phosphorylates targets in the cytosol
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
RHO GTPases activate CIT
Constitutive Signaling by AKT1 E17K in Cancer
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
PTK6 Regulates Cell Cycle
FLT3 Signaling
FOXO-mediated transcription of cell cycle genes
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases
Prostate cancer
GWAS
Appendicular lean mass (
33097823
)
Brain morphology (MOSTest) (
32665545
)
Diastolic blood pressure (
30487518
)
Mean arterial pressure (
29403010
30487518
)
Metabolite levels (
23823483
)
Monocyte percentage of white cells (
32888494
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Plateletcrit (
32888494
)
Prostate cancer (
29892016
31562322
)
Refractive error (
32231278
)
Systemic lupus erythematosus (
23273568
33272962
)
Systolic blood pressure (
30487518
)
Type 2 diabetes (
30297969
)
Interacting Genes
54 interacting genes:
AEBP2
APP
CCNA1
CCNA2
CCNB1
CCND2
CCNE1
CDK1
CDK11B
CDK2
CDK4
CDK5
CDK6
CDK7
CDKN1B
CRP
CTCFL
EED
EHMT2
EP300
EZH2
GADD45A
GZMA
IRAK4
KAT2B
LIMK1
LIMK2
LOX
NAP1L1
NAP1L4
NASP
NSD3
PAK4
PARP1
PARP3
PELP1
PRDM1
PRKCA
PRKCB
PRKCD
PRKCE
PRKCZ
PRKDC
PTMA
RBBP4
RPS6KA5
SET
SMYD5
SNCA
SUZ12
TAF1
TERF1
TERF2IP
TLK1
70 interacting genes:
ABL1
AKT1
ARHGDIA
ARIH1
CAMK1
CASP8
CCNA1
CCNA2
CCNB1
CCND1
CCND2
CCND3
CCNE2
CDC34
CDK2
CDK3
CDK4
CDK5
CKS1B
COP1
COPS5
CUL4A
DCLRE1C
GRB2
H1-1
H1-5
IRF1
KAT2B
KPNA1
KPNA3
KPNA4
KPNA5
KPNA6
LYN
MAPK10
MCM7
MTUS2
MYC
NUP50
PIN1
PSMB1
RCHY1
RNF123
RNF6
RPS6KA1
SGK1
SIRT6
SKP1
SKP2
SPDYA
SRC
STMN1
TRAF2
TSC2
UBAC1
UBB
UBE2B
UBE2D2
UBE2L3
UBE3A
UCHL1
WWP1
XPO1
YES1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
Entrez ID
3024
1027
HPRD ID
00820
02867
Ensembl ID
ENSG00000124610
ENSG00000111276
Uniprot IDs
Q02539
P46527
Q6I9V6
PDB IDs
9J8O
1H27
1JSU
2AST
5UQ3
6ATH
6P8E
6P8F
6P8G
7B5L
7B5M
7B5R
7OR8
7ORG
7ORH
7ORS
7ORT
8BYA
8BYL
8BZO
Enriched GO Terms of Interacting Partners
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Chromatin Organization
Protein Serine Kinase Activity
Protein Serine/threonine Kinase Activity
Chromatin Remodeling
Nucleus
Protein Kinase Activity
Kinase Activity
Cyclin-dependent Protein Kinase Holoenzyme Complex
Regulation Of Nucleobase-containing Compound Metabolic Process
Transferase Activity
G1/S Transition Of Mitotic Cell Cycle
Cell Cycle G1/S Phase Transition
Regulation Of RNA Metabolic Process
Nucleoplasm
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Protein Phosphorylation
Regulation Of Gene Expression
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Phosphorylation
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Mitotic Cell Cycle Phase Transition
Regulation Of Metabolic Process
Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Cell Cycle
Cell Cycle Phase Transition
Regulation Of Cell Cycle Process
Negative Regulation Of Metabolic Process
Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Cellular Response To Stress
Cellular Response To Oxygen-containing Compound
Negative Regulation Of Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Histone Binding
Positive Regulation Of Macromolecule Metabolic Process
Protein Modification Process
Response To Stress
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Negative Regulation Of RNA Metabolic Process
ESC/E(Z) Complex
Regulation Of Cell Cycle Phase Transition
Cell Division
Diacylglycerol-dependent Serine/threonine Kinase Activity
Protein Localization To Chromosome
Cell Cycle G1/S Phase Transition
G1/S Transition Of Mitotic Cell Cycle
Protein Modification Process
Nucleus
Cell Cycle Phase Transition
Nucleoplasm
Modification-dependent Protein Catabolic Process
Mitotic Cell Cycle Phase Transition
Cytosol
Post-translational Protein Modification
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Cytoplasm
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Protein Metabolic Process
Macromolecule Catabolic Process
Cyclin-dependent Protein Kinase Holoenzyme Complex
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Regulation Of Cell Cycle
Proteolysis
Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Protein Domain Specific Binding
Cellular Response To Stress
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Modification Process
Regulation Of Protein Metabolic Process
Intracellular Signal Transduction
Catabolic Process
Protein Polyubiquitination
Protein Localization To Nucleus
Transferase Activity
NLS-dependent Protein Nuclear Import Complex
Regulation Of Macromolecule Metabolic Process
Protein Catabolic Process
Regulation Of Metabolic Process
Ubiquitin-protein Transferase Activity
NLS-bearing Protein Import Into Nucleus
Regulation Of Nucleobase-containing Compound Metabolic Process
Proteasomal Protein Catabolic Process
Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
Regulation Of DNA Metabolic Process
Protein Import Into Nucleus
Import Into Nucleus
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Mitotic Cell Cycle
Ubiquitin Protein Ligase Binding
Protein Kinase Binding
Phosphoserine Residue Binding
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Tagcloud (Intersection)
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