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SEC61A1 and MLH1
Number of citations of the paper that reports this interaction (PMID
20706999
)
2
Data Source:
BioGRID
(two hybrid)
SEC61A1
MLH1
Gene Name
Sec61 alpha 1 subunit (S. cerevisiae)
mutL homolog 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Rough Endoplasmic Reticulum
Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Synaptonemal Complex
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Chiasma
Membrane
MutLalpha Complex
Molecular Function
Protein Binding
Ribosome Binding
Single-stranded DNA Binding
Protein Binding
ATP Binding
ATPase Activity
Guanine/thymine Mispair Binding
MutSalpha Complex Binding
Biological Process
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
SRP-dependent Cotranslational Protein Targeting To Membrane
Posttranslational Protein Targeting To Membrane
Endoplasmic Reticulum Organization
Cell Growth
Response To Interferon-gamma
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Protein Targeting To ER
Nuclear-transcribed MRNA Poly(A) Tail Shortening
Resolution Of Meiotic Recombination Intermediates
DNA Repair
Mismatch Repair
Double-strand Break Repair Via Nonhomologous End Joining
Male Meiosis Chromosome Segregation
Synapsis
Spermatogenesis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Somatic Hypermutation Of Immunoglobulin Genes
Meiotic Metaphase I Plate Congression
Isotype Switching
Negative Regulation Of Mitotic Recombination
Oogenesis
Meiotic Spindle Midzone Assembly
Pathways
Translation
SRP-dependent cotranslational protein targeting to membrane
Class I MHC mediated antigen processing & presentation
Antigen processing-Cross presentation
ER-Phagosome pathway
Adaptive Immune System
Meiotic recombination
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch Repair
Drugs
Diseases
GWAS
Protein-Protein Interactions
6 interactors:
ASNA1
BAG6
CALM1
HSPA5
MLH1
SERP1
74 interactors:
ABCC3
ABHD16A
ACER3
ACTG2
AGR2
AIFM1
ALDOA
ANXA6
AP2B1
APRT
ARAF
ASS1
ATF2
BLM
BRCA1
CAB39L
CAPN5
CASP3
CKAP4
CKB
CXorf57
DDX47
EEF1G
EEF2
EIF2A
ELP6
EXO1
EXOC3
FBXO32
FCGBP
FLNB
FRMD6
GABARAP
GSTP1
IGKC
KPNA2
LGALS4
MAP2K6
MBD4
MLH3
MSH3
MSH4
MUC2
MYC
MYL6
MYOG
NDRG1
NT5C3B
ORC4
PARP12
PARVA
PCNA
PMS1
PMS2
PSMA1
PTGDS
PTPRH
RAD23B
RAD9A
RAPGEFL1
SEC61A1
SELENBP1
SERPINF1
SPERT
SQSTM1
STAP2
TRIM23
TRIM29
TXN
TXN2
UBOX5
VAMP8
ZC3H11A
ZER1
Entrez ID
29927
4292
HPRD ID
15316
00390
Ensembl ID
ENSG00000058262
ENSG00000076242
Uniprot IDs
B3KME8
B3KNF6
P61619
P40692
Q59EG3
PDB IDs
3NA3
3RBN
Enriched GO Terms of Interacting Partners
?
Protein Insertion Into ER Membrane
Response To Endoplasmic Reticulum Stress
Protein Insertion Into Membrane
Membrane Organization
Substantia Nigra Development
Endoplasmic Reticulum Organization
Cellular Localization
Synapsis
Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
Neural Nucleus Development
Homologous Chromosome Segregation
Positive Regulation Of Nuclease Activity
Endomembrane System Organization
Platelet Degranulation
Positive Regulation Of Protein Kinase Activity
Meiotic Chromosome Segregation
Positive Regulation Of Kinase Activity
Protein Localization To Organelle
Midbrain Development
Endoplasmic Reticulum Unfolded Protein Response
Cellular Response To Stress
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Transferase Activity
Meiotic Spindle Midzone Assembly
Regulation Of Protein Folding In Endoplasmic Reticulum
Meiotic Metaphase I Plate Congression
Cellular Response To Unfolded Protein
Meiosis I
ER-nucleus Signaling Pathway
Cellular Response To Topologically Incorrect Protein
Response To Stress
Catabolic Process
Cell Activation
Response To Unfolded Protein
Negative Regulation Of Mitotic Recombination
Cerebellum Structural Organization
Positive Regulation Of Protein Phosphorylation
Glucose Metabolic Process
Regulation Of Protein Kinase Activity
Protein Localization
Regulation Of Cellular Protein Metabolic Process
Brain Development
Regulation Of Kinase Activity
Meiotic Nuclear Division
Head Development
Cellular Macromolecule Catabolic Process
System Development
Positive Regulation Of Phosphorylation
Intrinsic Apoptotic Signaling Pathway
Regulation Of Protein Metabolic Process
Cellular Response To Stress
Cellular Response To DNA Damage Stimulus
Cellular Response To Stimulus
Response To Stimulus
Mismatch Repair
Response To Stress
DNA Metabolic Process
DNA Catabolic Process
DNA Recombination
Negative Regulation Of Cell Cycle
DNA Repair
Cell Cycle
Cell Cycle Process
Cellular Nitrogen Compound Metabolic Process
Cellular Metabolic Process
Response To Organic Substance
DNA Damage Checkpoint
Mitotic DNA Damage Checkpoint
Mucus Secretion
Regulation Of Cell Cycle
Mitotic DNA Integrity Checkpoint
Nitrogen Compound Metabolic Process
Cellular Response To Organic Substance
Apoptotic Process
Programmed Cell Death
Nucleic Acid Phosphodiester Bond Hydrolysis
Cell Death
Death
Response To Abiotic Stimulus
Cell Cycle Checkpoint
Apoptotic Signaling Pathway
Nucleobase-containing Compound Metabolic Process
Cellular Response To Dexamethasone Stimulus
Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Response To Dexamethasone
Homeostatic Process
Mitotic Cell Cycle Checkpoint
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
DNA Catabolic Process, Exonucleolytic
Somatic Recombination Of Immunoglobulin Gene Segments
G2 DNA Damage Checkpoint
DNA Catabolic Process, Endonucleolytic
Regulation Of Apoptotic DNA Fragmentation
Somatic Diversification Of Immunoglobulins
Reciprocal Meiotic Recombination
Anatomical Structure Development
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Actin-mediated Cell Contraction
Tagcloud
?
9p24
actionable
arid1a
atlas
barr
bystander
cd274
cdkn2a
classifier
comes
comprises
cpg
ebv
enrollment
epstein
fail
gastrogenus
genomically
harbor
innocent
instability
intimately
l2
lytic
microsatellite
msi
noncoding
pdcd1lg2
qualify
Tagcloud (Difference)
?
9p24
actionable
arid1a
atlas
barr
bystander
cd274
cdkn2a
classifier
comes
comprises
cpg
ebv
enrollment
epstein
fail
gastrogenus
genomically
harbor
innocent
instability
intimately
l2
lytic
microsatellite
msi
noncoding
pdcd1lg2
qualify
Tagcloud (Intersection)
?