SEC61A1

Description		SEC61 translocon subunit alpha 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Signal Sequence Binding Calcium Channel Activity Protein Binding Protein Transmembrane Transporter Activity Ribosome Binding
	Biological Process	Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Endoplasmic Reticulum Organization Protein Transport Post-translational Protein Targeting To Membrane, Translocation Response To Type II Interferon Pronephric Nephron Development Protein Targeting To ER Protein Insertion Into ER Membrane Calcium Ion Transmembrane Transport
Pathways		ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Gestational age at birth (maternal effect) ( 28877031)
Novel Interacting Genes		2 novel interacting genes: ACAD9 PLXND1
Interacting Genes		10 interacting genes: BAG6 CALM1 GET3 HSPA5 MLH1 PTEN SEC61G SERP1 SLC13A1 TNF
Entrez ID		29927
HPRD ID		15316
Ensembl ID		ENSG00000058262
Uniprot IDs		B3KME8 B3KNF6 B4DR61 C9JXC6 P61619
PDB IDs		6W6L 8B6L 8DNV 8DNW 8DNX 8DNY 8DNZ 8DO0 8DO1 8DO2 8DO3
Enriched GO Terms of Interacting Partners?		Post-translational Protein Targeting To Membrane, Translocation Ribosome Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Tail-anchored Membrane Protein Insertion Into ER Membrane Intracellular Signal Transduction Misfolded Protein Binding Ubiquitin-specific Protease Binding Positive Regulation Of Protein Metabolic Process Protein Insertion Into ER Membrane Intracellular Protein Transmembrane Transport Protein Targeting To ER Intrinsic Apoptotic Signaling Pathway Establishment Of Protein Localization To Endoplasmic Reticulum Protein Insertion Into Membrane Establishment Of Protein Localization Substantia Nigra Development Negative Regulation Of High Voltage-gated Calcium Channel Activity Neural Nucleus Development Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Action Potential Cell Surface Receptor Signaling Pathway Via JAK-STAT Cellular Response To Type II Interferon Protein Transmembrane Transport Response To Endoplasmic Reticulum Stress Cerebellum Structural Organization Endoplasmic Reticulum Unfolded Protein Response Regulation Of Protein Folding In Endoplasmic Reticulum Meiotic Spindle Midzone Assembly Positive Regulation Of Immunoglobulin Mediated Immune Response Meiotic Metaphase Chromosome Alignment Positive Regulation Of Immunoglobulin Production Chiasma Apoptotic Signaling Pathway Late Recombination Nodule Regulation Of Immunoglobulin Production Chromosome Organization Involved In Meiotic Cell Cycle Meiotic Metaphase I Homologous Chromosome Alignment Positive Regulation Of Proteolysis Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Wound Healing Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Sodium:sulfate Symporter Activity Monoatomic Anion:sodium Symporter Activity Negative Regulation Of Bile Acid Secretion
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