ABR and PJA1

Number of citations of the paper that reports this interaction (PubMedID 21461837)
0

Data Source:
BioGRID (enzymatic study)

		ABR	PJA1
Description		ABR activator of RhoGEF and GTPase	praja ring finger ubiquitin ligase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Membrane Axon Cell Projection Dendritic Spine Synapse Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity	Protein Ubiquitination Protein Catabolic Process
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Appendicular lean mass ( 33097823) Heel bone mineral density ( 28869591 30598549) Height ( 28552196) Total cholesterol levels ( 30498476)	Birth weight ( 31043758) Body mass index ( 29273807) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		7 interacting genes: ADRA1A APP ECT2 ERBIN HRAS LNX1 PJA1	63 interacting genes: ABR ASCC2 ATP5F1C ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 DYRK1A EED ELAC1 ESPL1 EZH2 FGF12 GATD3 GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440
Entrez ID		29	64219
HPRD ID		02649	02335
Ensembl ID		ENSG00000159842	ENSG00000181191
Uniprot IDs		B7Z2X0 B7Z683 B7Z7Z1 I3L4Y1 Q12979 Q6ZT60	Q8NG27
PDB IDs			2L0B
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Blood Circulation Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Type II Interferon Production Postsynapse Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Cell Death Apoptotic Process Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of ERK1 And ERK2 Cascade Intracellular Signaling Cassette Positive Regulation Of Signaling Programmed Cell Death Amyloid-beta Complex Regulation Of Neuronal Synaptic Plasticity Growth Cone Lamellipodium Positive Regulation Of Establishment Of Protein Localization Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Type II Interferon Production Regulation Of Cytokine Production Glial Cell Development Adrenergic Receptor Binding Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Cellular Response To Ionizing Radiation Regulation Of Immune Response Regulation Of Cell Communication Cytoplasm Regulation Of Signal Transduction Developmental Cell Growth Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Pilomotor Reflex Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Positive Regulation Of MAPK Cascade Alpha1-adrenergic Receptor Activity Phospholipase C-activating Adrenergic Receptor Signaling Pathway Regulation Of Signaling Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Multicellular Organismal Process Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Modulation Of Chemical Synaptic Transmission Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury	Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Deubiquitinase Activity Cysteine-type Peptidase Activity Post-translational Protein Modification Ubiquitin Conjugating Enzyme Activity Proteolysis Protein Modification Process Peptidase Activity Deubiquitinase Activity Cytosol ATP Binding Pronucleus Ubiquitin Binding Protein K48-linked Deubiquitination Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Chromatin Silencing Complex Protein Polyubiquitination Macromolecule Metabolic Process Facultative Heterochromatin Formation ESC/E(Z) Complex Nucleotide Binding Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Cysteine-type Endopeptidase Activity DNA Repair Regulation Of Proteasomal Protein Catabolic Process Mitotic Cytokinesis Transferase Activity Protein K63-linked Deubiquitination DNA Damage Response Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Hydrolase Activity Protein Modification By Small Protein Conjugation DeNEDDylase Activity Sex Chromatin DNA Metabolic Process Ubiquitin-protein Transferase Activity Cytoskeleton-dependent Cytokinesis Kinase Activity Regulation Of Protein Catabolic Process Protein K11-linked Ubiquitination Negative Regulation Of Intracellular Signal Transduction Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Antibiotic Negative Regulation Of Signal Transduction By P53 Class Mediator
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