ABR and ECT2

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid)

		ABR	ECT2
Gene Name		active BCR-related	epithelial cell transforming 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Membrane	Nucleus Cytoplasm Cytosol Cell-cell Junction Tight Junction Midbody Nuclear Membrane Cleavage Furrow Intracellular Membrane-bounded Organelle Mitotic Spindle Centralspindlin Complex
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Rac GTPase Activator Activity	Signal Transducer Activity Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Rho GTPase Binding Protein Homodimerization Activity
	Biological Process	Small GTPase Mediated Signal Transduction Brain Development Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Response To Lipopolysaccharide Positive Regulation Of Rac GTPase Activity Inner Ear Morphogenesis Positive Regulation Of Apoptotic Process Negative Regulation Of Neutrophil Degranulation Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Neuromuscular Process Controlling Balance Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Cell Morphogenesis Cytokinesis Small GTPase Mediated Signal Transduction Protein Transport Activation Of Protein Kinase Activity Positive Regulation Of Rho GTPase Activity Positive Regulation Of Cytokinesis Activation Of Rho GTPase Activity Activation Of Rac GTPase Activity Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of Cdc42 GTPase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Apoptotic Signaling Pathway
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling	Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		5 interactors: ADRA1A APP ECT2 ERBB2IP LNX1	37 interactors: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 COX2 CRIPAK CSTB EIF4A2 EIF5B ERAL1 F2RL2 FANCM GGN ILVBL KLHL20 MBD1 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 TCEB1 THAP11 UBB VDAC2
Entrez ID		29	1894
HPRD ID		02649	11860
Ensembl ID		ENSG00000159842	ENSG00000114346
Uniprot IDs		B7Z2X0 B7Z683 B7Z7Z1 Q12979 Q6ZT60	G5E9L8 Q9H8V3
PDB IDs			3L46
Enriched GO Terms of Interacting Partners?		Cell Growth Growth Negative Regulation Of The Force Of Heart Contraction Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Basal Protein Localization Synaptic Growth At Neuromuscular Junction Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Collateral Sprouting In Absence Of Injury Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Apoptotic Process Programmed Cell Death Positive Regulation Of Hydrolase Activity Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Pilomotor Reflex Cell Death Death Positive Regulation Of Cell Cycle Process Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Protein Homooligomerization Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Axon Choice Point Recognition Micturition Positive Regulation Of Cardiac Muscle Contraction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Cycle Cellular Calcium Ion Homeostasis Regulation Of Phosphorylation Calcium Ion Homeostasis Regulation Of The Force Of Heart Contraction By Chemical Signal Neuron Remodeling Positive Regulation Of Action Potential Regulation Of Rho Protein Signal Transduction Positive Regulation Of Protein Kinase C Signaling Negative Regulation Of Heart Rate Regulation Of Phosphorus Metabolic Process Positive Regulation Of Striated Muscle Contraction Intracellular Transport Positive Regulation Of Catalytic Activity Positive Regulation Of Systemic Arterial Blood Pressure Activation Of Rac GTPase Activity Cellular Metal Ion Homeostasis Adrenergic Receptor Signaling Pathway Response To Oxidative Stress Positive Regulation Of Synaptic Transmission, GABAergic Protein Oligomerization Cellular Cation Homeostasis Response To Radiation	Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Modification-dependent Protein Catabolic Process Mitotic Cell Cycle Checkpoint Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Cellular Protein Catabolic Process Response To Stress Cellular Response To DNA Damage Stimulus Regulation Of Apoptotic Process Protein Catabolic Process Cellular Response To Stress Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell Death Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Cell Cycle Checkpoint Regulation Of Proteolysis Regulation Of Catalytic Activity Mitotic DNA Damage Checkpoint Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Mitotic DNA Integrity Checkpoint Negative Regulation Of Cell Cycle Negative Regulation Of Protein Ubiquitination Mitotic Cell Cycle Phase Transition Cell Cycle Cell Cycle Phase Transition
Tagcloud ?		amplitude averaged bounded coefficients comparable components considerably deviation envelope exceeded fit intersubject intrasubject latency measurement measures middle mlr occasions oddball pa subject tended terms variability variation waveform waveforms waves	broader correlate correlates cytoskeleton dbl dbs deregulated encodes exchange family gtpases guanine jun lfc lsc mpk2 nh2 oncogenes panel possess rho sets specificities structurally transformed transforming utilization versions weakly
Tagcloud (Difference) ?		amplitude averaged bounded coefficients comparable components considerably deviation envelope exceeded fit intersubject intrasubject latency measurement measures middle mlr occasions oddball pa subject tended terms variability variation waveform waveforms waves	broader correlate correlates cytoskeleton dbl dbs deregulated encodes exchange family gtpases guanine jun lfc lsc mpk2 nh2 oncogenes panel possess rho sets specificities structurally transformed transforming utilization versions weakly
Tagcloud (Intersection) ?