ABR

Name	ABR activator of RhoGEF and GTPase
Structure	No pdb structure
Novel Interactors	1 novel interactors: C1QBP
Interactors	7 interactors: ADRA1A APP ECT2 ERBIN HRAS LNX1 PJA1
GO Annotations	Cellular Component	Cytosol Membrane Axon Cell Projection Dendritic Spine Synapse Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity
Pathways	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
GWAS	Age-related cognitive decline (memory) (slope of z-scores) ( 30954325 ) Appendicular lean mass ( 33097823 ) Heel bone mineral density ( 28869591 30598549 ) Height ( 28552196 ) Total cholesterol levels ( 30498476 )
Entrez ID	29
HPRD ID	02649
Ensembl ID	ENSG00000159842
Uniprot IDs	B7Z2X0 B7Z683 B7Z7Z1 I3L4Y1 Q12979 Q6ZT60
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Negative Regulation Of Blood Circulation Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Type II Interferon Production Postsynapse Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Cell Death Apoptotic Process Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of ERK1 And ERK2 Cascade Intracellular Signaling Cassette Positive Regulation Of Signaling Programmed Cell Death Amyloid-beta Complex Regulation Of Neuronal Synaptic Plasticity Growth Cone Lamellipodium Positive Regulation Of Establishment Of Protein Localization Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Type II Interferon Production Regulation Of Cytokine Production Glial Cell Development Adrenergic Receptor Binding Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Cellular Response To Ionizing Radiation Regulation Of Immune Response Regulation Of Cell Communication Cytoplasm Regulation Of Signal Transduction Developmental Cell Growth Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Pilomotor Reflex Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Positive Regulation Of MAPK Cascade Alpha1-adrenergic Receptor Activity Phospholipase C-activating Adrenergic Receptor Signaling Pathway Regulation Of Signaling Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Multicellular Organismal Process Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Modulation Of Chemical Synaptic Transmission Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury