ABR and ADRA1A

Number of citations of the paper that reports this interaction (PMID 15525470)
1

Data Source:
HPRD (in vitro, two hybrid)

		ABR	ADRA1A
Gene Name		active BCR-related	adrenoceptor alpha 1A
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Membrane	Nucleus Plasma Membrane Integral Component Of Plasma Membrane Z Disc T-tubule Nuclear Membrane
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Rac GTPase Activator Activity	Alpha1-adrenergic Receptor Activity Protein Heterodimerization Activity
	Biological Process	Small GTPase Mediated Signal Transduction Brain Development Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Response To Lipopolysaccharide Positive Regulation Of Rac GTPase Activity Inner Ear Morphogenesis Positive Regulation Of Apoptotic Process Negative Regulation Of Neutrophil Degranulation Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Neuromuscular Process Controlling Balance Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Systemic Arterial Blood Pressure Apoptotic Process Smooth Muscle Contraction Signal Transduction G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Adult Heart Development Aging Negative Regulation Of Cell Proliferation Response To Hormone Cell Growth Positive Regulation Of Synaptic Transmission, GABAergic Negative Regulation Of Rho Protein Signal Transduction Organ Growth Intracellular Signal Transduction Response To Drug Positive Regulation Of MAPK Cascade Positive Regulation Of Action Potential Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Micturition Calcium Ion Transport Into Cytosol Positive Regulation Of Cardiac Muscle Contraction Positive Regulation Of ERK1 And ERK2 Cascade Adrenergic Receptor Signaling Pathway Positive Regulation Of Protein Kinase C Signaling Pilomotor Reflex
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling	G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding G alpha (q) signalling events GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Adrenoceptors G alpha (12/13) signalling events
Drugs			Midodrine Citalopram Ziprasidone Dapiprazole Amitriptyline Olanzapine Alfuzosin Clozapine Norepinephrine Phenylephrine Phenylpropanolamine Promazine Dipivefrin Droperidol Prazosin Imipramine Chlorpromazine Nortriptyline Amoxapine Doxazosin Labetalol Metaraminol Nicardipine Trazodone Epinephrine Thioridazine Phentolamine Ergotamine Nicergoline Tamsulosin Methoxamine Trimipramine Risperidone Epinastine Propiomazine Tolazoline Trifluoperazine Pseudoephedrine Benzphetamine Flupenthixol Phenoxybenzamine Maprotiline Oxymetazoline Apraclonidine Ergoloid mesylate Promethazine Carvedilol Doxepin Nefazodone Desipramine Terazosin Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Ergonovine Paliperidone Dihydroergotoxine Bevantolol Ephedrine Mephentermine Methotrimeprazine 4-Methoxyamphetamine Dextroamphetamine Phendimetrazine Acepromazine Thioproperazine Zuclopenthixol Dronedarone Iloperidone Sertindole Silodosin Asenapine Droxidopa Xylometazoline Isometheptene Levonordefrin Naphazoline
Diseases
GWAS			Response to amphetamines ( 22952603)
Protein-Protein Interactions		5 interactors: ADRA1A APP ECT2 ERBB2IP LNX1	10 interactors: ABR ADRA1B ADRA1D BMP1 CXCR1 CXCR2 FLNC NOS1 PPP1R9B RGS2
Entrez ID		29	148
HPRD ID		02649	00081
Ensembl ID		ENSG00000159842	ENSG00000120907
Uniprot IDs		B7Z2X0 B7Z683 B7Z7Z1 Q12979 Q6ZT60	B0ZBD3 P35348
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Growth Growth Negative Regulation Of The Force Of Heart Contraction Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Basal Protein Localization Synaptic Growth At Neuromuscular Junction Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Collateral Sprouting In Absence Of Injury Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Apoptotic Process Programmed Cell Death Positive Regulation Of Hydrolase Activity Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Pilomotor Reflex Cell Death Death Positive Regulation Of Cell Cycle Process Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Protein Homooligomerization Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Axon Choice Point Recognition Micturition Positive Regulation Of Cardiac Muscle Contraction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Cycle Cellular Calcium Ion Homeostasis Regulation Of Phosphorylation Calcium Ion Homeostasis Regulation Of The Force Of Heart Contraction By Chemical Signal Neuron Remodeling Positive Regulation Of Action Potential Regulation Of Rho Protein Signal Transduction Positive Regulation Of Protein Kinase C Signaling Negative Regulation Of Heart Rate Regulation Of Phosphorus Metabolic Process Positive Regulation Of Striated Muscle Contraction Intracellular Transport Positive Regulation Of Catalytic Activity Positive Regulation Of Systemic Arterial Blood Pressure Activation Of Rac GTPase Activity Cellular Metal Ion Homeostasis Adrenergic Receptor Signaling Pathway Response To Oxidative Stress Positive Regulation Of Synaptic Transmission, GABAergic Protein Oligomerization Cellular Cation Homeostasis Response To Radiation	Blood Circulation Interleukin-8-mediated Signaling Pathway Regulation Of Heart Contraction Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Dendritic Cell Chemotaxis Developmental Process Adrenergic Receptor Signaling Pathway Regulation Of Muscle Contraction Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Dendritic Cell Migration Regulation Of Blood Pressure Positive Regulation Of Heart Contraction Regulation Of The Force Of Heart Contraction Vasoconstriction Positive Regulation Of Blood Pressure Response To Morphine Receptor Internalization Negative Regulation Of Blood Pressure Response To Organic Substance Chemokine-mediated Signaling Pathway Cell Migration Cell Motility Negative Regulation Of Neutrophil Apoptotic Process Positive Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Vasoconstriction Of Artery Involved In Baroreceptor Response To Lowering Of Systemic Arterial Blood Pressure Negative Regulation Of The Force Of Heart Contraction Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Receptor Metabolic Process Cellular Response To Organic Substance Response To Ammonium Ion Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Leukocyte Chemotaxis Positive Regulation Of Glycogen Catabolic Process Negative Regulation Of Glycogen Catabolic Process Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Opioid Receptor Signaling Pathway Negative Regulation Of Neutrophil Degranulation G-protein Coupled Receptor Signaling Pathway Anatomical Structure Development Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Locomotion Regulation Of Neutrophil Degranulation Positive Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Adrenergic Receptor Signaling Pathway
Tagcloud ?		amplitude averaged bounded coefficients comparable components considerably deviation envelope exceeded fit intersubject intrasubject latency measurement measures middle mlr occasions oddball pa subject tended terms variability variation waveform waveforms waves	adra2b adrenergic arg347cys bk2r check chronotropic dbp enos exercise glu298asp melting neurohumoral nitric overt paulo polymorphisms programme reserve rs1048101 rs1799983 rs2070744 rs28365031 rs553668 rs5810761 sao sbp synthase treadmill
Tagcloud (Difference) ?		amplitude averaged bounded coefficients comparable components considerably deviation envelope exceeded fit intersubject intrasubject latency measurement measures middle mlr occasions oddball pa subject tended terms variability variation waveform waveforms waves	adra2b adrenergic arg347cys bk2r check chronotropic dbp enos exercise glu298asp melting neurohumoral nitric overt paulo polymorphisms programme reserve rs1048101 rs1799983 rs2070744 rs28365031 rs553668 rs5810761 sao sbp synthase treadmill
Tagcloud (Intersection) ?