HIPK2 and FBXW7

Number of citations of the paper that reports this interaction (PMID 18765672)
15

Data Source:
HPRD (in vivo)

		HIPK2	FBXW7
Gene Name		homeodomain interacting protein kinase 2	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Nuclear Body PML Body RNA Polymerase II Transcription Factor Complex	Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Golgi Apparatus SCF Ubiquitin Ligase Complex Protein Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding SMAD Binding Virion Binding	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Cyclin Binding Protein Binding, Bridging Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin-protein Transferase Activator Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Eye Development Positive Regulation Of Protein Phosphorylation Transcription, DNA-templated Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Transforming Growth Factor Beta Receptor Signaling Pathway Smoothened Signaling Pathway Adult Walking Behavior Positive Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Retina Layer Formation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Modulation By Virus Of Host Morphology Or Physiology Neuron Differentiation Erythrocyte Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway PML Body Organization Positive Regulation Of Protein Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Embryonic Camera-type Eye Morphogenesis Voluntary Musculoskeletal Movement Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cell Cycle Embryonic Retina Morphogenesis In Camera-type Eye Lens Induction In Camera-type Eye SMAD Protein Signal Transduction Iris Morphogenesis Cellular Response To Hypoxia Intrinsic Apoptotic Signaling Pathway	Vasculogenesis Vasculature Development Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Sister Chromatid Cohesion Notch Signaling Pathway Negative Regulation Of Triglyceride Biosynthetic Process Regulation Of Lipid Storage Viral Process Protein Ubiquitination Lung Development SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Negative Regulation Of DNA Endoreduplication Regulation Of Protein Localization Cellular Response To UV Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Notch Signaling Pathway Protein Stabilization Positive Regulation Of Ubiquitin-protein Transferase Activity Lipid Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of SREBP Signaling Pathway
Pathways		Generic Transcription Pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression	Protein folding Antigen processing: Ubiquitination & Proteasome degradation Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		48 interactors: AATF BTRC CHMP4B CREBBP CUL1 CXCL1 DAXX DDX39A DDX39B EP300 FBXW7 HIST2H2BE HMGA1 KAT2B MAP3K7 MBP MDM2 MECP2 MKNK1 MYB MYBL1 NKX2-1 NKX2-5 NKX3-1 NLK PAX6 PML PTCH1 RANBP9 RUNX1 SENP1 SIAH1 SIAH2 SKI SMAD1 SMAD2 SMAD3 SP100 SUMO1 SUMO2 TP53 TP53INP1 TP63 TP73 TRADD UBE2I WSB1 ZBTB4	33 interactors: ARL6IP1 CCNE1 CCNE2 CDC34 CREB3L1 CREB3L2 CUL1 EBNA1BP2 FAM101A GLMN GNB2L1 HEY1 HIPK2 JUN KIAA1875 KLF5 LINGO1 MCL1 MED13 MED13L MMS22L MYB MYC NOTCH1 NOTCH4 PARK2 PPARGC1A PSEN1 SHPRH SKP1 STOML1 SUMF2 UBE2D1
Entrez ID		28996	55294
HPRD ID		06039	05888
Ensembl ID		ENSG00000064393	ENSG00000109670
Uniprot IDs		Q9H2X6	B7Z2C8 G0Z2K0 Q969H0 S4R3U4
PDB IDs			2OVP 2OVQ 2OVR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Viral Process Response To Organic Substance Apoptotic Process Transcription, DNA-templated Cellular Response To Organic Substance Tube Development Regulation Of Signaling Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of Cell Death Regulation Of Protein Metabolic Process Response To Stimulus Cell Death Death Regulation Of Signal Transduction Negative Regulation Of Cell Proliferation Regulation Of Apoptotic Process Regulation Of Cell Proliferation Cell Cycle RNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Transcription From RNA Polymerase II Promoter Cell Cycle Process Regulation Of Cell Cycle Cell Communication Gene Expression Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway	Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Notch Signaling Pathway Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Neuron Death Cellular Response To Stress Regulation Of Neuron Apoptotic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Transcription, DNA-templated Positive Regulation Of Cellular Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process G1/S Transition Of Mitotic Cell Cycle RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Proteolysis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Response To Organic Substance Nitrogen Compound Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Regulation Of Protein Ubiquitination Negative Regulation Of Neuron Death Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Regulation Of Protein Catabolic Process Positive Regulation Of Apoptotic Process Cellular Response To Stimulus Positive Regulation Of Programmed Cell Death Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Death Cell Cycle Phase Transition Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Gene Expression
Tagcloud ?		adding complexity decisions determines e3 fail fate favoring feedback finger homeodomain inactivated interferes ligase loop preferentially proline siah2 stimulates switch termination ubiquitin ubiquitination uncovers waf1 xaf1 xiap zinc znf313	bcl11b cadherin discovered dnm2 druggable exhibitedthe fat1 frequencies guide harboured herc1 jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2
Tagcloud (Difference) ?		adding complexity decisions determines e3 fail fate favoring feedback finger homeodomain inactivated interferes ligase loop preferentially proline siah2 stimulates switch termination ubiquitin ubiquitination uncovers waf1 xaf1 xiap zinc znf313	bcl11b cadherin discovered dnm2 druggable exhibitedthe fat1 frequencies guide harboured herc1 jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2
Tagcloud (Intersection) ?