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HIPK2 and NKX2-1
Number of citations of the paper that reports this interaction (PMID
11438542
)
28
Data Source:
HPRD
(two hybrid, in vitro)
HIPK2
NKX2-1
Gene Name
homeodomain interacting protein kinase 2
NK2 homeobox 1
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Nuclear Body
PML Body
RNA Polymerase II Transcription Factor Complex
Nucleus
Nucleoplasm
Transcription Factor Complex
Molecular Function
RNA Polymerase II Activating Transcription Factor Binding
RNA Polymerase II Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
SMAD Binding
Virion Binding
Core Promoter Binding
Intronic Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Enzyme Binding
Sequence-specific DNA Binding
Transcription Regulatory Region DNA Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Eye Development
Positive Regulation Of Protein Phosphorylation
Transcription, DNA-templated
Protein Phosphorylation
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
Transforming Growth Factor Beta Receptor Signaling Pathway
Smoothened Signaling Pathway
Adult Walking Behavior
Positive Regulation Of Cell Proliferation
Anterior/posterior Pattern Specification
Retina Layer Formation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Modulation By Virus Of Host Morphology Or Physiology
Neuron Differentiation
Erythrocyte Differentiation
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
PML Body Organization
Positive Regulation Of Protein Binding
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of DNA Binding
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of JNK Cascade
Embryonic Camera-type Eye Morphogenesis
Voluntary Musculoskeletal Movement
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Cell Cycle
Embryonic Retina Morphogenesis In Camera-type Eye
Lens Induction In Camera-type Eye
SMAD Protein Signal Transduction
Iris Morphogenesis
Cellular Response To Hypoxia
Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Neuron Migration
Transcription From RNA Polymerase II Promoter
Phospholipid Metabolic Process
Axon Guidance
Brain Development
Endoderm Development
Locomotory Behavior
Response To Hormone
Positive Regulation Of Gene Expression
Negative Regulation Of Epithelial To Mesenchymal Transition
Globus Pallidus Development
Hippocampus Development
Cerebral Cortex Cell Migration
Forebrain Dorsal/ventral Pattern Formation
Forebrain Neuron Fate Commitment
Cerebral Cortex GABAergic Interneuron Differentiation
Pituitary Gland Development
Lung Development
Negative Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Thyroid Gland Development
Forebrain Development
Developmental Induction
Leydig Cell Differentiation
Positive Regulation Of Circadian Rhythm
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Rhythmic Process
Anatomical Structure Formation Involved In Morphogenesis
Oligodendrocyte Differentiation
Lung Saccule Development
Epithelial Tube Branching Involved In Lung Morphogenesis
Clara Cell Differentiation
Type II Pneumocyte Differentiation
Pathways
Generic Transcription Pathway
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Drugs
Diseases
GWAS
Height (
18391950
)
Menarche (age at onset) (
23667675
)
Thyroid cancer (
19198613
)
Protein-Protein Interactions
48 interactors:
AATF
BTRC
CHMP4B
CREBBP
CUL1
CXCL1
DAXX
DDX39A
DDX39B
EP300
FBXW7
HIST2H2BE
HMGA1
KAT2B
MAP3K7
MBP
MDM2
MECP2
MKNK1
MYB
MYBL1
NKX2-1
NKX2-5
NKX3-1
NLK
PAX6
PML
PTCH1
RANBP9
RUNX1
SENP1
SIAH1
SIAH2
SKI
SMAD1
SMAD2
SMAD3
SP100
SUMO1
SUMO2
TP53
TP53INP1
TP63
TP73
TRADD
UBE2I
WSB1
ZBTB4
14 interactors:
CALR
CREBBP
GATA6
HIPK2
MAPK1
NCOA1
NCOA2
NCOA3
PAX8
PTRF
RARA
RELA
TDG
WWTR1
Entrez ID
28996
7080
HPRD ID
06039
02798
Ensembl ID
ENSG00000064393
ENSG00000136352
Uniprot IDs
Q9H2X6
P43699
PDB IDs
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Positive Regulation Of Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Gene Expression
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transcription, DNA-templated
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Viral Process
Response To Organic Substance
Apoptotic Process
Transcription, DNA-templated
Cellular Response To Organic Substance
Tube Development
Regulation Of Signaling
Programmed Cell Death
Positive Regulation Of Transcription From RNA Polymerase II Promoter
RNA Biosynthetic Process
Regulation Of Cell Death
Regulation Of Protein Metabolic Process
Response To Stimulus
Cell Death
Death
Regulation Of Signal Transduction
Negative Regulation Of Cell Proliferation
Regulation Of Apoptotic Process
Regulation Of Cell Proliferation
Cell Cycle
RNA Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Transcription From RNA Polymerase II Promoter
Cell Cycle Process
Regulation Of Cell Cycle
Cell Communication
Gene Expression
Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Cellular Biosynthetic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Gene Expression
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Macromolecule Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
RNA Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of RNA Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Cellular Response To Organic Substance
Biosynthetic Process
Regulation Of Gene Expression
Cellular Response To Hormone Stimulus
Regulation Of Nitrogen Compound Metabolic Process
Response To Hormone
Intracellular Receptor Signaling Pathway
Regulation Of Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Embryo Development
Gland Development
Response To Organic Substance
Positive Regulation Of Metabolic Process
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Cell Differentiation
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Organ Morphogenesis
Embryonic Morphogenesis
Nitrogen Compound Metabolic Process
Intracellular Steroid Hormone Receptor Signaling Pathway
Tissue Development
Anatomical Structure Morphogenesis
Response To Estrogen
Regulation Of Metabolic Process
Response To Steroid Hormone
Positive Regulation Of Cell Proliferation
Tagcloud
?
adding
complexity
decisions
determines
e3
fail
fate
favoring
feedback
finger
homeodomain
inactivated
interferes
ligase
loop
preferentially
proline
siah2
stimulates
switch
termination
ubiquitin
ubiquitination
uncovers
waf1
xaf1
xiap
zinc
znf313
Tagcloud (Difference)
?
adding
complexity
decisions
determines
e3
fail
fate
favoring
feedback
finger
homeodomain
inactivated
interferes
ligase
loop
preferentially
proline
siah2
stimulates
switch
termination
ubiquitin
ubiquitination
uncovers
waf1
xaf1
xiap
zinc
znf313
Tagcloud (Intersection)
?