HIPK2 and WSB1

Number of citations of the paper that reports this interaction (PMID 18093972)
15

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		HIPK2	WSB1
Gene Name		homeodomain interacting protein kinase 2	WD repeat and SOCS box containing 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Nuclear Body PML Body RNA Polymerase II Transcription Factor Complex	Intracellular
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding SMAD Binding Virion Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Eye Development Positive Regulation Of Protein Phosphorylation Transcription, DNA-templated Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Transforming Growth Factor Beta Receptor Signaling Pathway Smoothened Signaling Pathway Adult Walking Behavior Positive Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Retina Layer Formation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Modulation By Virus Of Host Morphology Or Physiology Neuron Differentiation Erythrocyte Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway PML Body Organization Positive Regulation Of Protein Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Embryonic Camera-type Eye Morphogenesis Voluntary Musculoskeletal Movement Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cell Cycle Embryonic Retina Morphogenesis In Camera-type Eye Lens Induction In Camera-type Eye SMAD Protein Signal Transduction Iris Morphogenesis Cellular Response To Hypoxia Intrinsic Apoptotic Signaling Pathway	Biological_process Protein Ubiquitination Intracellular Signal Transduction
Pathways		Generic Transcription Pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Chronic myeloid leukemia ( 21540461) Dental caries ( 23064961)
Protein-Protein Interactions		48 interactors: AATF BTRC CHMP4B CREBBP CUL1 CXCL1 DAXX DDX39A DDX39B EP300 FBXW7 HIST2H2BE HMGA1 KAT2B MAP3K7 MBP MDM2 MECP2 MKNK1 MYB MYBL1 NKX2-1 NKX2-5 NKX3-1 NLK PAX6 PML PTCH1 RANBP9 RUNX1 SENP1 SIAH1 SIAH2 SKI SMAD1 SMAD2 SMAD3 SP100 SUMO1 SUMO2 TP53 TP53INP1 TP63 TP73 TRADD UBE2I WSB1 ZBTB4	5 interactors: CSF3R DIO2 GSK3B HIPK2 UBE2D3
Entrez ID		28996	26118
HPRD ID		06039	15680
Ensembl ID		ENSG00000064393	ENSG00000109046
Uniprot IDs		Q9H2X6	B4DGB8 Q9Y6I7
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Viral Process Response To Organic Substance Apoptotic Process Transcription, DNA-templated Cellular Response To Organic Substance Tube Development Regulation Of Signaling Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of Cell Death Regulation Of Protein Metabolic Process Response To Stimulus Cell Death Death Regulation Of Signal Transduction Negative Regulation Of Cell Proliferation Regulation Of Apoptotic Process Regulation Of Cell Proliferation Cell Cycle RNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Transcription From RNA Polymerase II Promoter Cell Cycle Process Regulation Of Cell Cycle Cell Communication Gene Expression Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway	Positive Regulation Of Protein Binding Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Organic Substance Cellular Response To Oxygen Levels Peptidyl-serine Phosphorylation Positive Regulation Of Binding Immune System Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Binding Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Thyroid Hormone Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Response To Organic Substance Response To Transforming Growth Factor Beta Apoptotic Process Organ Morphogenesis Programmed Cell Death Hypermethylation Of CpG Island Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Voluntary Musculoskeletal Movement Cell Death Death Response To Abiotic Stimulus PML Body Organization Cellular Response To Interleukin-3 Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Binding Selenocysteine Incorporation Regulation Of Neuron Maturation Negative Regulation Of Glycogen (starch) Synthase Activity Cell Surface Receptor Signaling Pathway Response To Hypoxia Hormone Catabolic Process Protein Localization To Microtubule Defense Response Negative Regulation Of Biosynthetic Process Iris Morphogenesis Negative Regulation Of Dendrite Morphogenesis Negative Regulation Of NFAT Protein Import Into Nucleus Response To Stress Apoptotic Signaling Pathway Lens Induction In Camera-type Eye ER Overload Response
Tagcloud ?		adding complexity decisions determines e3 fail fate favoring feedback finger homeodomain inactivated interferes ligase loop preferentially proline siah2 stimulates switch termination ubiquitin ubiquitination uncovers waf1 xaf1 xiap zinc znf313	293t carrier chimera chimeric d2 deiodinase deiodinases deiodination direction e3 extensively globular govern hek insertion instability introducing k237 k244 ligase lysines march6 readily teb4 thyroxine transiently ubiquitinate ubiquitination unless
Tagcloud (Difference) ?		adding complexity decisions determines fail fate favoring feedback finger homeodomain inactivated interferes loop preferentially proline siah2 stimulates switch termination ubiquitin uncovers waf1 xaf1 xiap zinc znf313	293t carrier chimera chimeric d2 deiodinase deiodinases deiodination direction extensively globular govern hek insertion instability introducing k237 k244 lysines march6 readily teb4 thyroxine transiently ubiquitinate unless
Tagcloud (Intersection) ?		e3 ligase ubiquitination