HIPK2 and NKX3-1

Number of citations of the paper that reports this interaction (PubMedID 10559189)
0

Data Source:
HPRD (in vitro, in vivo)

		HIPK2	NKX3-1
Description		homeodomain interacting protein kinase 2	NK3 homeobox 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoplasmic Stress Granule Nuclear Body PML Body Protein-containing Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Cytosol Site Of DNA Damage
	Molecular Function	Nucleotide Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity SMAD Binding Virion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Serine Kinase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Nuclear Estrogen Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding MADS Box Domain Binding DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Eye Development Respiratory System Process Protein Phosphorylation Apoptotic Process DNA Damage Response Transforming Growth Factor Beta Receptor Signaling Pathway Smoothened Signaling Pathway Adult Walking Behavior Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Adult Locomotory Behavior Anterior/posterior Pattern Specification Gene Expression Retina Layer Formation Peptidyl-serine Phosphorylation Neuron Differentiation Erythrocyte Differentiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway PML Body Organization Thyroid Gland Development Epigenetic Regulation Of Gene Expression Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Embryonic Camera-type Eye Morphogenesis Voluntary Musculoskeletal Movement Neuron Apoptotic Process Regulation Of Cell Cycle Embryonic Retina Morphogenesis In Camera-type Eye Lens Induction In Camera-type Eye SMAD Protein Signal Transduction Lung Morphogenesis Iris Morphogenesis Cellular Response To Hypoxia Intrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Urogenital System Development Metanephros Development Somitogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process DNA Damage Response Salivary Gland Development Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Regulation Of Signal Transduction Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Differentiation Androgen Receptor Signaling Pathway Prostate Gland Development Regulation Of Protein Localization Response To Testosterone Response To Lipid Dorsal Aorta Development Regulation Of Cell Population Proliferation Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Branching Morphogenesis Of An Epithelial Tube Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Pharyngeal System Development Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Steroid Hormone Stimulus Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Positive Regulation Of Androgen Secretion Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression SUMOylation of transcription cofactors Physiological factors Regulation of TP53 Activity through Phosphorylation RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MECP2 expression and activity
Drugs		Fostamatinib
Diseases			Prostate cancer
GWAS		Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Systolic blood pressure ( 28135244)	Birth weight ( 31043758) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular hemoglobin concentration ( 29403010) Prostate cancer ( 26443449 32986714 34012061) Prostate-specific antigen levels ( 28139693) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		57 interacting genes: AATF ABL1 BTRC CBX3 CHMP4B CREBBP CUL1 CXCL1 DAXX DAZAP2 DDX39A DDX39B FBXW7 H2BC21 HMGA1 KAT2B MAP3K7 MBP MDM2 MECP2 MKNK1 MYB MYBL1 NKX2-1 NKX2-5 NKX3-1 NLK NTRK1 PARP1 PAX6 PML PTCH1 RANBP9 RUNX1 SENP1 SETX SIAH1 SIAH2 SIRT1 SKI SMAD1 SMAD2 SMAD3 SP100 SPOP STIP1 SUMO1 SUMO2 SUMO3 TP53 TP53INP1 TP63 TP73 TRADD UBE2I WSB1 ZBTB4	38 interacting genes: AEN CCT7 CD200R1L CENPX CHPF CKAP4 FEM1B HIPK2 HMG20B HNRNPA0 HSP90B1 LMCD1 MAN2B1 MNAT1 MRE11 MT-ND4 PEBP1 PTMS RABL6 RARG RHOXF2 RNF4 RPL37A RPSA SLC67A1 SP1 SP2 SP3 SP4 SP5 SPDEF SRF STMN3 TEX264 TOPORS TPT1 WDR77 ZNF417
Entrez ID		28996	4824
HPRD ID		06039	03620
Ensembl ID		ENSG00000064393	ENSG00000167034
Uniprot IDs		Q9H2X6	Q99801
PDB IDs		6P5S 7NCF	2L9R
Enriched GO Terms of Interacting Partners?		Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Nucleus Positive Regulation Of DNA-templated Transcription Ubiquitin Protein Ligase Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process PML Body Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Stress Negative Regulation Of Developmental Process Nuclear Body Regulation Of Programmed Cell Death Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Apoptotic Process Rhythmic Process DNA Damage Response Negative Regulation Of Cell Differentiation Regulation Of Apoptotic Process Programmed Cell Death P53 Binding Cell Death Macromolecule Metabolic Process	Nucleus DNA Binding PML Body Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Trachea Cartilage Development Sequence-specific Double-stranded DNA Binding Embryonic Eye Morphogenesis Glandular Epithelial Cell Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Sequence-specific DNA Binding Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Apoptotic Process Double-stranded DNA Binding Regulation Of Programmed Cell Death DNA Damage Response Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Eye Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sensory Organ Morphogenesis Columnar/cuboidal Epithelial Cell Development Embryonic Camera-type Eye Morphogenesis Zinc Ion Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Trophectodermal Cell Differentiation Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Face Development Regulation Of Macromolecule Biosynthetic Process Prostate Gland Epithelium Morphogenesis RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Macromolecule Metabolic Process Signal Transduction By P53 Class Mediator Cellular Response To Stress Replication Fork Positive Regulation Of Macromolecule Metabolic Process Mitochondrial Double-strand Break Repair Via Homologous Recombination Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Cellular Response To Wortmannin Thyroid Gland Development
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