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HIPK2 and NKX3-1
Number of citations of the paper that reports this interaction (PMID
10559189
)
44
Data Source:
HPRD
(in vivo, in vitro)
HIPK2
NKX3-1
Gene Name
homeodomain interacting protein kinase 2
NK3 homeobox 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Nuclear Body
PML Body
RNA Polymerase II Transcription Factor Complex
Intracellular
Nucleus
Molecular Function
RNA Polymerase II Activating Transcription Factor Binding
RNA Polymerase II Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
SMAD Binding
Virion Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity
Core Promoter Binding
Sequence-specific DNA Binding Transcription Factor Activity
Androgen Receptor Activity
Protein Binding
Transcription Factor Binding
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Estrogen Receptor Activity
Protein Kinase Activator Activity
Estrogen Receptor Binding
Histone Deacetylase Binding
Sequence-specific DNA Binding
Protein Self-association
Transcription Regulatory Region DNA Binding
MADS Box Domain Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Eye Development
Positive Regulation Of Protein Phosphorylation
Transcription, DNA-templated
Protein Phosphorylation
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
Transforming Growth Factor Beta Receptor Signaling Pathway
Smoothened Signaling Pathway
Adult Walking Behavior
Positive Regulation Of Cell Proliferation
Anterior/posterior Pattern Specification
Retina Layer Formation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Modulation By Virus Of Host Morphology Or Physiology
Neuron Differentiation
Erythrocyte Differentiation
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
PML Body Organization
Positive Regulation Of Protein Binding
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of DNA Binding
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of JNK Cascade
Embryonic Camera-type Eye Morphogenesis
Voluntary Musculoskeletal Movement
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Cell Cycle
Embryonic Retina Morphogenesis In Camera-type Eye
Lens Induction In Camera-type Eye
SMAD Protein Signal Transduction
Iris Morphogenesis
Cellular Response To Hypoxia
Intrinsic Apoptotic Signaling Pathway
Metanephros Development
Somitogenesis
Positive Regulation Of Protein Phosphorylation
Regulation Of Transcription, DNA-templated
Transcription From RNA Polymerase II Promoter
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Multicellular Organismal Development
Salivary Gland Development
Heart Development
Positive Regulation Of Cell Proliferation
Negative Regulation Of Cell Proliferation
Male Gonad Development
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Cell Death
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Androgen Receptor Signaling Pathway
Response To Testosterone
Cellular Response To Drug
Dorsal Aorta Development
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Steroid Hormone Mediated Signaling Pathway
Protein Kinase B Signaling
Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Branching Morphogenesis Of An Epithelial Tube
Negative Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Cell Division
Pharyngeal System Development
Branching Involved In Prostate Gland Morphogenesis
Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis
Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Cellular Response To Steroid Hormone Stimulus
Cellular Response To Hypoxia
Mitotic Cell Cycle Arrest
Negative Regulation Of Estrogen Receptor Binding
Positive Regulation Of Androgen Secretion
Positive Regulation Of Response To DNA Damage Stimulus
Positive Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Generic Transcription Pathway
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Drugs
Diseases
GWAS
Protein-Protein Interactions
48 interactors:
AATF
BTRC
CHMP4B
CREBBP
CUL1
CXCL1
DAXX
DDX39A
DDX39B
EP300
FBXW7
HIST2H2BE
HMGA1
KAT2B
MAP3K7
MBP
MDM2
MECP2
MKNK1
MYB
MYBL1
NKX2-1
NKX2-5
NKX3-1
NLK
PAX6
PML
PTCH1
RANBP9
RUNX1
SENP1
SIAH1
SIAH2
SKI
SMAD1
SMAD2
SMAD3
SP100
SUMO1
SUMO2
TP53
TP53INP1
TP63
TP73
TRADD
UBE2I
WSB1
ZBTB4
32 interactors:
AEN
CCT7
CHPF
CKAP4
FEM1B
HIPK2
HMG20B
HNRNPA0
HSP90B1
LMCD1
MAN2B1
MNAT1
ND4
PEBP1
PTMS
RABL6
RARG
RPL37A
RPSA
SP1
SP2
SP3
SP4
SP5
SPDEF
SRF
STMN3
STRA13
TEX264
TOPORS
TPT1
WDR77
Entrez ID
28996
4824
HPRD ID
06039
03620
Ensembl ID
ENSG00000064393
ENSG00000167034
Uniprot IDs
Q9H2X6
Q99801
PDB IDs
2L9R
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Positive Regulation Of Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Gene Expression
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transcription, DNA-templated
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Viral Process
Response To Organic Substance
Apoptotic Process
Transcription, DNA-templated
Cellular Response To Organic Substance
Tube Development
Regulation Of Signaling
Programmed Cell Death
Positive Regulation Of Transcription From RNA Polymerase II Promoter
RNA Biosynthetic Process
Regulation Of Cell Death
Regulation Of Protein Metabolic Process
Response To Stimulus
Cell Death
Death
Regulation Of Signal Transduction
Negative Regulation Of Cell Proliferation
Regulation Of Apoptotic Process
Regulation Of Cell Proliferation
Cell Cycle
RNA Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Transcription From RNA Polymerase II Promoter
Cell Cycle Process
Regulation Of Cell Cycle
Cell Communication
Gene Expression
Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Signaling Pathway
Nucleobase-containing Compound Metabolic Process
RNA Metabolic Process
RNA Biosynthetic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Nitrogen Compound Metabolic Process
Gene Expression
Cellular Nitrogen Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Transcription, DNA-templated
Embryonic Eye Morphogenesis
Transcription From RNA Polymerase II Promoter
Cellular Metabolic Process
Embryonic Camera-type Eye Development
Regulation Of Transcription From RNA Polymerase II Promoter
Eye Morphogenesis
Biosynthetic Process
Megakaryocyte Differentiation
Trophectodermal Cell Differentiation
Camera-type Eye Development
Eye Development
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Erythrocyte Differentiation
Erythrocyte Homeostasis
Blastocyst Formation
Embryonic Camera-type Eye Morphogenesis
Camera-type Eye Morphogenesis
Organ Morphogenesis
Myeloid Cell Homeostasis
Organ Development
Embryonic Organ Development
Glandular Epithelial Cell Differentiation
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Embryonic Organ Morphogenesis
Regulation Of Transcription, DNA-templated
Regulation Of Gene Expression
Regulation Of Nucleic Acid-templated Transcription
Regulation Of Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Embryonic Process Involved In Female Pregnancy
Sensory Organ Development
Prostate Gland Development
Regulation Of RNA Metabolic Process
Enucleate Erythrocyte Differentiation
Positive Regulation Of Transcription, DNA-templated
Tissue Development
System Development
Homeostasis Of Number Of Cells
Tagcloud
?
adding
complexity
decisions
determines
e3
fail
fate
favoring
feedback
finger
homeodomain
inactivated
interferes
ligase
loop
preferentially
proline
siah2
stimulates
switch
termination
ubiquitin
ubiquitination
uncovers
waf1
xaf1
xiap
zinc
znf313
Tagcloud (Difference)
?
adding
complexity
decisions
determines
e3
fail
fate
favoring
feedback
finger
homeodomain
inactivated
interferes
ligase
loop
preferentially
proline
siah2
stimulates
switch
termination
ubiquitin
ubiquitination
uncovers
waf1
xaf1
xiap
zinc
znf313
Tagcloud (Intersection)
?