HIPK2 and CHMP4B

Number of citations of the paper that reports this interaction (PubMedID 16730941)
0

Data Source:
HPRD (two hybrid)

		HIPK2	CHMP4B
Description		homeodomain interacting protein kinase 2	charged multivesicular body protein 4B
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoplasmic Stress Granule Nuclear Body PML Body Protein-containing Complex RNA Polymerase II Transcription Regulator Complex	Autophagosome Membrane Kinetochore ESCRT III Complex Nucleus Nuclear Envelope Nuclear Pore Cytoplasm Lysosomal Membrane Endosome Multivesicular Body Kinetochore Microtubule Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Membrane Coat Midbody Late Endosome Membrane Vesicle Multivesicular Body Membrane Extracellular Exosome Amphisome Membrane
	Molecular Function	Nucleotide Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity SMAD Binding Virion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Serine Kinase Activity	Protein Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Eye Development Respiratory System Process Protein Phosphorylation Apoptotic Process DNA Damage Response Transforming Growth Factor Beta Receptor Signaling Pathway Smoothened Signaling Pathway Adult Walking Behavior Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Adult Locomotory Behavior Anterior/posterior Pattern Specification Gene Expression Retina Layer Formation Peptidyl-serine Phosphorylation Neuron Differentiation Erythrocyte Differentiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway PML Body Organization Thyroid Gland Development Epigenetic Regulation Of Gene Expression Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Embryonic Camera-type Eye Morphogenesis Voluntary Musculoskeletal Movement Neuron Apoptotic Process Regulation Of Cell Cycle Embryonic Retina Morphogenesis In Camera-type Eye Lens Induction In Camera-type Eye SMAD Protein Signal Transduction Lung Morphogenesis Iris Morphogenesis Cellular Response To Hypoxia Intrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Mitotic Cytokinesis Plasma Membrane Repair Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Vesicle Budding From Membrane Autophagy Nucleus Organization Vacuolar Transport Mitotic Metaphase Chromosome Alignment Exit From Mitosis Regulation Of Centrosome Duplication Protein Transport Macroautophagy Nuclear Membrane Reassembly Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Maintenance Of Lens Transparency Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Viral Budding Viral Budding From Plasma Membrane Nervous System Process Protein Polymerization Vesicle Fusion With Vacuole Multivesicular Body-lysosome Fusion Midbody Abscission Multivesicular Body Sorting Pathway Membrane Fission Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Autophagosome Maturation Regulation Of Mitotic Spindle Assembly Late Endosome To Lysosome Transport
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression SUMOylation of transcription cofactors Physiological factors Regulation of TP53 Activity through Phosphorylation RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MECP2 expression and activity	Budding and maturation of HIV virion Macroautophagy Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
Drugs		Fostamatinib
Diseases
GWAS		Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Systolic blood pressure ( 28135244)	Feeling nervous ( 29500382) Loneliness ( 27629369) Offspring birth weight ( 31043758) Refractive error ( 32231278) Stearic acid (18:0) levels ( 23362303)
Interacting Genes		57 interacting genes: AATF ABL1 BTRC CBX3 CHMP4B CREBBP CUL1 CXCL1 DAXX DAZAP2 DDX39A DDX39B FBXW7 H2BC21 HMGA1 KAT2B MAP3K7 MBP MDM2 MECP2 MKNK1 MYB MYBL1 NKX2-1 NKX2-5 NKX3-1 NLK NTRK1 PARP1 PAX6 PML PTCH1 RANBP9 RUNX1 SENP1 SETX SIAH1 SIAH2 SIRT1 SKI SMAD1 SMAD2 SMAD3 SP100 SPOP STIP1 SUMO1 SUMO2 SUMO3 TP53 TP53INP1 TP63 TP73 TRADD UBE2I WSB1 ZBTB4	18 interacting genes: CEBPA CHMP1B CHMP3 CHMP4A CHMP4C CHMP5 CHMP6 EXOSC9 HIPK2 NOD2 PDCD6IP PIAS2 PLIN3 PTPN23 SNCA STAMBP UBE2I VPS4A
Entrez ID		28996	128866
HPRD ID		06039	16642
Ensembl ID		ENSG00000064393	ENSG00000101421
Uniprot IDs		Q9H2X6	Q9H444
PDB IDs		6P5S 7NCF	3C3Q 3UM3 4ABM 5MK2
Enriched GO Terms of Interacting Partners?		Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Nucleus Positive Regulation Of DNA-templated Transcription Ubiquitin Protein Ligase Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process PML Body Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Stress Negative Regulation Of Developmental Process Nuclear Body Regulation Of Programmed Cell Death Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Apoptotic Process Rhythmic Process DNA Damage Response Negative Regulation Of Cell Differentiation Regulation Of Apoptotic Process Programmed Cell Death P53 Binding Cell Death Macromolecule Metabolic Process	Viral Budding Via Host ESCRT Complex Midbody Abscission Nuclear Membrane Reassembly Viral Budding Mitotic Cytokinetic Process Viral Budding From Plasma Membrane Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Assembly Multivesicular Body Organization Late Endosome To Vacuole Transport Cytokinetic Process Late Endosome To Lysosome Transport Endosome Transport Via Multivesicular Body Sorting Pathway Mitotic Metaphase Chromosome Alignment Regulation Of Mitotic Spindle Assembly Multivesicular Body Sorting Pathway Nucleus Organization Nuclear Membrane Organization ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Membrane Assembly Metaphase Chromosome Alignment Viral Release From Host Cell Multivesicular Body-lysosome Fusion Plasma Membrane Repair Regulation Of Spindle Assembly Lysosomal Membrane Organization Chromosome Localization Endosome Organization Regulation Of Mitotic Spindle Organization Nuclear Pore Membrane Fission Kinetochore Microtubule Autophagosome Maturation Multivesicular Body Membrane Viral Process Regulation Of Microtubule Cytoskeleton Organization Vacuolar Transport Multivesicular Body Vesicle Fusion Autophagy Organelle Membrane Fusion Autophagosome Membrane Plasma Membrane Organization Lysosomal Transport Endosome Organelle Fusion Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Protein-containing Complex Disassembly
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