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HIPK2 and SIAH1
Number of citations of the paper that reports this interaction (PubMedID
33591310
)
61
Data Source:
BioGRID
(affinity chromatography technology, enzymatic study)
HIPK2
SIAH1
Description
homeodomain interacting protein kinase 2
siah E3 ubiquitin protein ligase 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytoplasmic Stress Granule
Nuclear Body
PML Body
Protein-containing Complex
RNA Polymerase II Transcription Regulator Complex
Nucleus
Cytoplasm
Early Endosome
Cytosol
Beta-catenin Destruction Complex
Molecular Function
Nucleotide Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
SMAD Binding
Virion Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Protein Serine Kinase Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Ubiquitin Conjugating Enzyme Binding
Identical Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Eye Development
Respiratory System Process
Protein Phosphorylation
Apoptotic Process
DNA Damage Response
Transforming Growth Factor Beta Receptor Signaling Pathway
Smoothened Signaling Pathway
Adult Walking Behavior
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Adult Locomotory Behavior
Anterior/posterior Pattern Specification
Gene Expression
Retina Layer Formation
Peptidyl-serine Phosphorylation
Neuron Differentiation
Erythrocyte Differentiation
DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
PML Body Organization
Thyroid Gland Development
Epigenetic Regulation Of Gene Expression
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Embryonic Camera-type Eye Morphogenesis
Voluntary Musculoskeletal Movement
Neuron Apoptotic Process
Regulation Of Cell Cycle
Embryonic Retina Morphogenesis In Camera-type Eye
Lens Induction In Camera-type Eye
SMAD Protein Signal Transduction
Lung Morphogenesis
Iris Morphogenesis
Cellular Response To Hypoxia
Intrinsic Apoptotic Signaling Pathway
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Spermatogenesis
Nervous System Development
Axon Guidance
Anatomical Structure Morphogenesis
Protein Ubiquitination
Cell Differentiation
Protein Catabolic Process
Protein Destabilization
Positive Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Neuron Apoptotic Process
Canonical Wnt Signaling Pathway
Amyloid Fibril Formation
Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
YAP1- and WWTR1 (TAZ)-stimulated gene expression
SUMOylation of transcription cofactors
Physiological factors
Regulation of TP53 Activity through Phosphorylation
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of MECP2 expression and activity
Netrin-1 signaling
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Fostamatinib
Diseases
GWAS
Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis (
26980576
)
Systolic blood pressure (
28135244
)
Femur bone mineral density x serum urate levels interaction (
34046847
)
Height (
28552196
)
Mean corpuscular hemoglobin (
32888494
)
Waist circumference (
28552196
)
Interacting Genes
57 interacting genes:
AATF
ABL1
BTRC
CBX3
CHMP4B
CREBBP
CUL1
CXCL1
DAXX
DAZAP2
DDX39A
DDX39B
FBXW7
H2BC21
HMGA1
KAT2B
MAP3K7
MBP
MDM2
MECP2
MKNK1
MYB
MYBL1
NKX2-1
NKX2-5
NKX3-1
NLK
NTRK1
PARP1
PAX6
PML
PTCH1
RANBP9
RUNX1
SENP1
SETX
SIAH1
SIAH2
SIRT1
SKI
SMAD1
SMAD2
SMAD3
SP100
SPOP
STIP1
SUMO1
SUMO2
SUMO3
TP53
TP53INP1
TP63
TP73
TRADD
UBE2I
WSB1
ZBTB4
157 interacting genes:
AASDHPPT
AFF1
AFF4
APC
AQP1
ARMC9
ATN1
ATXN7
AXIN1
AXIN2
BAG1
BAG3
BAG4
BCL6
CACYBP
CAPG
CCDC198
CDC23
CDC34
CDK5R1
COPS5
DAB1
DAZAP2
DCC
DDX41
DNAJC15
DNALI1
EEF1D
EIF3J
ELL2
EXOC3-AS1
FAM90A1
FLI1
FZD9
GAPDH
GDPD5
GRM5
H4C16
HCFC1
HIF1AN
HIPK2
HIPK3
INHA
IQCN
ITSN1
KATNAL1
KCNJ10
KHDRBS3
KIAA0319L
KIAA1217
KIF1B
KIF22
KIFC3
KLF10
LACTB2
LANCL2
LMNA
M1AP
MAB21L1
MAP3K5
MAPK12
MAPKBP1
MAPRE3
MOB3C
MTIF3
MX1
NANOS2
NANOS3
NECTIN2
NELFA
NHERF2
NOL6
NTAQ1
NUMB
NUMBL
OPRM1
OTUB2
PARD6B
PCDH17
PEG10
PEG3
PFKM
PHC1
PHC2
PIAS2
PIAS3
PIMREG
PINK1
PKD1
POU2AF1
PRPF31
PRR20B
PRR20C
PRR20D
PRR20E
PTPMT1
PUF60
PYGB
QRICH1
RAB33A
RAB33B
RAD51AP1
RAD54L2
RAPH1
RBBP8
RPL27A
RPS19BP1
RXRB
SDCBP
SFMBT2
SH3RF1
SLAIN1
SNCAIP
SPATA4
SPATC1L
SYP
SYT7
TBC1D22B
TERF2
TFDP1
TMEM43
TNK2
TOLLIP
TP53BP2
TRIM23
TRIM27
TRIM7
TRIM8
TUBA1A
TUBA1B
TUBA3C
TUBA4A
TUBA8
TXN
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E3
UBE2I
UBE2K
UBE2L6
UBE2N
UBE2V2
UPP2
USP19
UXT
VAV1
ZBP1
ZCCHC10
ZCCHC13
ZFYVE21
ZMAT3
ZNF148
ZNF512B
ZNF671
ZYX
Entrez ID
28996
6477
HPRD ID
06039
03736
Ensembl ID
ENSG00000064393
ENSG00000196470
Uniprot IDs
Q9H2X6
Q8IUQ4
PDB IDs
6P5S
7NCF
2A25
4C9Z
4CA1
4I7B
4I7C
4I7D
4X3G
5WZZ
8HEO
9G0L
Enriched GO Terms of Interacting Partners
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Nucleoplasm
Positive Regulation Of RNA Biosynthetic Process
Nucleus
Positive Regulation Of DNA-templated Transcription
Ubiquitin Protein Ligase Binding
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
PML Body
Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
DNA-binding Transcription Factor Binding
Transforming Growth Factor Beta Receptor Signaling Pathway
Intracellular Signal Transduction
Cellular Response To Stress
Negative Regulation Of Developmental Process
Nuclear Body
Regulation Of Programmed Cell Death
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Apoptotic Process
Rhythmic Process
DNA Damage Response
Negative Regulation Of Cell Differentiation
Regulation Of Apoptotic Process
Programmed Cell Death
P53 Binding
Cell Death
Macromolecule Metabolic Process
Nucleus
Ubiquitin Conjugating Enzyme Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Nucleoplasm
Cytoplasm
Protein Modification By Small Protein Conjugation
Protein Polyubiquitination
Perinuclear Region Of Cytoplasm
Microtubule Cytoskeleton
Post-translational Protein Modification
Identical Protein Binding
Beta-catenin Destruction Complex
Ubiquitin-protein Transferase Activity
Protein K48-linked Ubiquitination
Nuclear Body
Regulation Of JNK Cascade
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleotide Binding
Protein Ubiquitination
Cell Death
Microtubule-based Process
Apoptotic Process
SUMO Transferase Activity
Negative Regulation Of RNA Metabolic Process
Regulation Of RNA Metabolic Process
Programmed Cell Death
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Protein K63-linked Ubiquitination
Regulation Of Primary Metabolic Process
Microtubule Cytoskeleton Organization
Microtubule
Regulation Of Macromolecule Metabolic Process
Microtubule Binding
Organelle Organization
Regulation Of Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Lateral Ventricle Development
Astrocyte Projection
Positive Regulation Of Post-translational Protein Modification
Establishment Of Mitochondrion Localization
UBC13-MMS2 Complex
Neuroblast Division In Subventricular Zone
Modification-dependent Protein Catabolic Process
Regulation Of DNA-templated Transcription
Adenyl-nucleotide Exchange Factor Activity
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
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