HIPK2 and CXCL1

Number of citations of the paper that reports this interaction (PMID 15896780)
6

Data Source:
BioGRID (pull down)

		HIPK2	CXCL1
Gene Name		homeodomain interacting protein kinase 2	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Nuclear Body PML Body RNA Polymerase II Transcription Factor Complex	Extracellular Region Extracellular Space
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding SMAD Binding Virion Binding	Receptor Binding Chemokine Activity Enzyme Activator Activity Growth Factor Activity CXCR Chemokine Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Eye Development Positive Regulation Of Protein Phosphorylation Transcription, DNA-templated Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Transforming Growth Factor Beta Receptor Signaling Pathway Smoothened Signaling Pathway Adult Walking Behavior Positive Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Retina Layer Formation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Modulation By Virus Of Host Morphology Or Physiology Neuron Differentiation Erythrocyte Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway PML Body Organization Positive Regulation Of Protein Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Embryonic Camera-type Eye Morphogenesis Voluntary Musculoskeletal Movement Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cell Cycle Embryonic Retina Morphogenesis In Camera-type Eye Lens Induction In Camera-type Eye SMAD Protein Signal Transduction Iris Morphogenesis Cellular Response To Hypoxia Intrinsic Apoptotic Signaling Pathway	Positive Regulation Of Leukocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response Signal Transduction G-protein Coupled Receptor Signaling Pathway Nervous System Development Cell Proliferation Negative Regulation Of Cell Proliferation Actin Cytoskeleton Organization Response To Lipopolysaccharide Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Generic Transcription Pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		48 interactors: AATF BTRC CHMP4B CREBBP CUL1 CXCL1 DAXX DDX39A DDX39B EP300 FBXW7 HIST2H2BE HMGA1 KAT2B MAP3K7 MBP MDM2 MECP2 MKNK1 MYB MYBL1 NKX2-1 NKX2-5 NKX3-1 NLK PAX6 PML PTCH1 RANBP9 RUNX1 SENP1 SIAH1 SIAH2 SKI SMAD1 SMAD2 SMAD3 SP100 SUMO1 SUMO2 TP53 TP53INP1 TP63 TP73 TRADD UBE2I WSB1 ZBTB4	5 interactors: ACKR1 CXCR1 CXCR2 HIPK2 MMP9
Entrez ID		28996	2919
HPRD ID		06039	01119
Ensembl ID		ENSG00000064393	ENSG00000163739
Uniprot IDs		Q9H2X6	P09341
PDB IDs			1MGS 1MSG 1MSH 1ROD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Viral Process Response To Organic Substance Apoptotic Process Transcription, DNA-templated Cellular Response To Organic Substance Tube Development Regulation Of Signaling Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of Cell Death Regulation Of Protein Metabolic Process Response To Stimulus Cell Death Death Regulation Of Signal Transduction Negative Regulation Of Cell Proliferation Regulation Of Apoptotic Process Regulation Of Cell Proliferation Cell Cycle RNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Transcription From RNA Polymerase II Promoter Cell Cycle Process Regulation Of Cell Cycle Cell Communication Gene Expression Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway	Interleukin-8-mediated Signaling Pathway Chemokine-mediated Signaling Pathway Dendritic Cell Chemotaxis Leukocyte Migration Dendritic Cell Migration Receptor Internalization Cell Surface Receptor Signaling Pathway Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Binding Receptor Metabolic Process Cellular Response To Cytokine Stimulus Chemotaxis Leukocyte Chemotaxis Cellular Response To Organic Substance Negative Regulation Of Neutrophil Apoptotic Process Response To Cytokine Positive Regulation Of Binding Positive Regulation Of Angiogenesis Immune System Process Regulation Of Protein Binding Cell Migration Cell Chemotaxis Cell Motility Signal Transduction Response To Organic Substance Signaling Positive Regulation Of Receptor Binding Voluntary Musculoskeletal Movement Regulation Of Angiogenesis Cell Communication Positive Regulation Of Keratinocyte Migration PML Body Organization Myeloid Cell Differentiation G-protein Coupled Receptor Signaling Pathway Regulation Of Binding Acute Inflammatory Response To Antigenic Stimulus Locomotion Defense Response Iris Morphogenesis Cellular Response To Stimulus Positive Regulation Of Cell Migration Positive Regulation Of Vascular Permeability Positive Regulation Of Cell Motility Response To Stress Positive Regulation Of Cellular Component Movement Lens Induction In Camera-type Eye Metanephric Tubule Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Locomotion
Tagcloud ?		adding complexity decisions determines e3 fail fate favoring feedback finger homeodomain inactivated interferes ligase loop preferentially proline siah2 stimulates switch termination ubiquitin ubiquitination uncovers waf1 xaf1 xiap zinc znf313	backgroundmonocyte ccl3 ccl4 ccl7 cd45 chemokines conclusionsour contrasted contributors degenerating degenerations deoxynucleotidyl dutp euthanized facs govern ld lux markdawley methodssprague muller nick photoreceptor pigment resultsexposure retinal retinas rpe
Tagcloud (Difference) ?		adding complexity decisions determines e3 fail fate favoring feedback finger homeodomain inactivated interferes ligase loop preferentially proline siah2 stimulates switch termination ubiquitin ubiquitination uncovers waf1 xaf1 xiap zinc znf313	backgroundmonocyte ccl3 ccl4 ccl7 cd45 chemokines conclusionsour contrasted contributors degenerating degenerations deoxynucleotidyl dutp euthanized facs govern ld lux markdawley methodssprague muller nick photoreceptor pigment resultsexposure retinal retinas rpe
Tagcloud (Intersection) ?