HIPK2 and TP53INP1

Number of citations of the paper that reports this interaction (PubMedID 12851404)
0

Data Source:
HPRD (in vitro, in vivo)

		HIPK2	TP53INP1
Description		homeodomain interacting protein kinase 2	tumor protein p53 inducible nuclear protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoplasmic Stress Granule Nuclear Body PML Body Protein-containing Complex RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol PML Body Cytoplasmic Vesicle
	Molecular Function	Nucleotide Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity SMAD Binding Virion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Serine Kinase Activity	Protein Binding Antioxidant Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Eye Development Respiratory System Process Protein Phosphorylation Apoptotic Process DNA Damage Response Transforming Growth Factor Beta Receptor Signaling Pathway Smoothened Signaling Pathway Adult Walking Behavior Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Adult Locomotory Behavior Anterior/posterior Pattern Specification Gene Expression Retina Layer Formation Peptidyl-serine Phosphorylation Neuron Differentiation Erythrocyte Differentiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway PML Body Organization Thyroid Gland Development Epigenetic Regulation Of Gene Expression Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Embryonic Camera-type Eye Morphogenesis Voluntary Musculoskeletal Movement Neuron Apoptotic Process Regulation Of Cell Cycle Embryonic Retina Morphogenesis In Camera-type Eye Lens Induction In Camera-type Eye SMAD Protein Signal Transduction Lung Morphogenesis Iris Morphogenesis Cellular Response To Hypoxia Intrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Autophagosome Assembly Autophagy Apoptotic Process Negative Regulation Of Cell Population Proliferation Response To Heat Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Cell Migration Cellular Response To UV Positive Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Autophagic Cell Death Negative Regulation Of Fibroblast Proliferation Regulation Of Cell Cycle Cellular Response To Ethanol Cellular Response To Hydroperoxide Cellular Response To Methyl Methanesulfonate Cellular Oxidant Detoxification Negative Regulation Of Myofibroblast Differentiation
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression SUMOylation of transcription cofactors Physiological factors Regulation of TP53 Activity through Phosphorylation RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MECP2 expression and activity	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Regulation of TP53 Activity through Phosphorylation
Drugs		Fostamatinib
Diseases
GWAS		Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Systolic blood pressure ( 28135244)	Alzheimer's disease ( 31473137) Fasting glucose ( 34059833) Hemoglobin levels ( 32327693) Intraocular pressure ( 29617998) Keratoconus ( 33649486) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Macular thickness ( 30535121) Platelet distribution width ( 32888494) Serum uric acid levels ( 30993211 29403010) Type 2 diabetes ( 20581827 30297969 30054458 32499647 28869590 24509480 22885922) Urate levels ( 31578528)
Interacting Genes		57 interacting genes: AATF ABL1 BTRC CBX3 CHMP4B CREBBP CUL1 CXCL1 DAXX DAZAP2 DDX39A DDX39B FBXW7 H2BC21 HMGA1 KAT2B MAP3K7 MBP MDM2 MECP2 MKNK1 MYB MYBL1 NKX2-1 NKX2-5 NKX3-1 NLK NTRK1 PARP1 PAX6 PML PTCH1 RANBP9 RUNX1 SENP1 SETX SIAH1 SIAH2 SIRT1 SKI SMAD1 SMAD2 SMAD3 SP100 SPOP STIP1 SUMO1 SUMO2 SUMO3 TP53 TP53INP1 TP63 TP73 TRADD UBE2I WSB1 ZBTB4	11 interacting genes: GABARAP GABARAPL1 GABARAPL2 HIPK2 MAP1LC3A MAP1LC3C SEC22A SQSTM1 TP53 UNC119 YPEL3
Entrez ID		28996	94241
HPRD ID		06039	09367
Ensembl ID		ENSG00000064393	ENSG00000164938
Uniprot IDs		Q9H2X6	Q96A56
PDB IDs		6P5S 7NCF
Enriched GO Terms of Interacting Partners?		Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Nucleus Positive Regulation Of DNA-templated Transcription Ubiquitin Protein Ligase Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process PML Body Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Stress Negative Regulation Of Developmental Process Nuclear Body Regulation Of Programmed Cell Death Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Apoptotic Process Rhythmic Process DNA Damage Response Negative Regulation Of Cell Differentiation Regulation Of Apoptotic Process Programmed Cell Death P53 Binding Cell Death Macromolecule Metabolic Process	Mitophagy Autophagy Of Mitochondrion Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Macroautophagy Autophagosome Autophagosome Maturation Ubiquitin Protein Ligase Binding Autophagy Autophagosome Membrane Cellular Response To Starvation Response To Starvation Autophagosome Assembly Autophagosome Organization Cellular Response To Nutrient Levels Phospholipid Binding Protein-containing Complex Disassembly Vacuole Organization GABA Receptor Binding Response To Nutrient Levels Cellular Response To Stress Protein Transport Organelle Assembly Beta-tubulin Binding Establishment Of Protein Localization Cytoplasmic Vesicle Organelle Organization Autolysosome Intracellular Protein Localization Aggrephagy PML Body Positive Regulation Of Cellular Senescence Microtubule Catabolic Process Regulation Of Proteolysis Cellular Response To Decreased Oxygen Levels Negative Regulation Of Proteolysis Protein-containing Complex Organization SMAD Protein Signal Transduction Cytoskeleton Response To Stress Cellular Response To Oxygen Levels Regulation Of Protein Metabolic Process Regulation Of ATP-dependent Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cellular Component Assembly Organelle Membrane Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Senescence DNA Damage Response, Signal Transduction By P53 Class Mediator
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