HIPK2 and TP53INP1

Number of citations of the paper that reports this interaction (PMID 12851404)
26

Data Source:
HPRD (in vivo, in vitro)

		HIPK2	TP53INP1
Gene Name		homeodomain interacting protein kinase 2	tumor protein p53 inducible nuclear protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Nuclear Body PML Body RNA Polymerase II Transcription Factor Complex	Nucleus Autophagic Vacuole Cytosol PML Body Cytoplasmic Vesicle
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding SMAD Binding Virion Binding	Protein Binding Antioxidant Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Eye Development Positive Regulation Of Protein Phosphorylation Transcription, DNA-templated Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Transforming Growth Factor Beta Receptor Signaling Pathway Smoothened Signaling Pathway Adult Walking Behavior Positive Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Retina Layer Formation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Modulation By Virus Of Host Morphology Or Physiology Neuron Differentiation Erythrocyte Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway PML Body Organization Positive Regulation Of Protein Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Embryonic Camera-type Eye Morphogenesis Voluntary Musculoskeletal Movement Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cell Cycle Embryonic Retina Morphogenesis In Camera-type Eye Lens Induction In Camera-type Eye SMAD Protein Signal Transduction Iris Morphogenesis Cellular Response To Hypoxia Intrinsic Apoptotic Signaling Pathway	Autophagic Vacuole Assembly Transcription, DNA-templated Apoptotic Process Response To Stress Cell Cycle Arrest Negative Regulation Of Cell Proliferation Response To Heat Positive Regulation Of Autophagy Negative Regulation Of Cell Migration Cellular Response To UV Positive Regulation Of Transcription, DNA-templated Autophagic Cell Death Cellular Response To Ethanol Cellular Response To Hydroperoxide Cellular Response To Methyl Methanesulfonate Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Generic Transcription Pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression
Drugs
Diseases
GWAS			Type 2 diabetes ( 20581827)
Protein-Protein Interactions		48 interactors: AATF BTRC CHMP4B CREBBP CUL1 CXCL1 DAXX DDX39A DDX39B EP300 FBXW7 HIST2H2BE HMGA1 KAT2B MAP3K7 MBP MDM2 MECP2 MKNK1 MYB MYBL1 NKX2-1 NKX2-5 NKX3-1 NLK PAX6 PML PTCH1 RANBP9 RUNX1 SENP1 SIAH1 SIAH2 SKI SMAD1 SMAD2 SMAD3 SP100 SUMO1 SUMO2 TP53 TP53INP1 TP63 TP73 TRADD UBE2I WSB1 ZBTB4	2 interactors: HIPK2 TP53
Entrez ID		28996	94241
HPRD ID		06039	09367
Ensembl ID		ENSG00000064393	ENSG00000164938
Uniprot IDs		Q9H2X6	Q96A56
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Viral Process Response To Organic Substance Apoptotic Process Transcription, DNA-templated Cellular Response To Organic Substance Tube Development Regulation Of Signaling Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of Cell Death Regulation Of Protein Metabolic Process Response To Stimulus Cell Death Death Regulation Of Signal Transduction Negative Regulation Of Cell Proliferation Regulation Of Apoptotic Process Regulation Of Cell Proliferation Cell Cycle RNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Transcription From RNA Polymerase II Promoter Cell Cycle Process Regulation Of Cell Cycle Cell Communication Gene Expression Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway	DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator DNA Damage Response, Signal Transduction By P53 Class Mediator Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Intrinsic Apoptotic Signaling Pathway Response To Transforming Growth Factor Beta Regulation Of Neuron Apoptotic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Anterior/posterior Pattern Specification Regulation Of Neuron Death Cell Fate Commitment Response To Hypoxia Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Apoptotic Signaling Pathway Negative Regulation Of Helicase Activity Voluntary Musculoskeletal Movement PML Body Organization Pattern Specification Process Embryonic Organ Development Positive Regulation Of Cell Aging Positive Regulation Of Thymocyte Apoptotic Process Mitochondrial DNA Repair Viral Process Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Glial Cell Apoptotic Process Cellular Response To Growth Factor Stimulus Behavior Response To Growth Factor Iris Morphogenesis Oxidative Stress-induced Premature Senescence Hemopoiesis Embryonic Morphogenesis Lens Induction In Camera-type Eye ER Overload Response Negative Regulation Of Macroautophagy
Tagcloud ?		adding complexity decisions determines e3 fail fate favoring feedback finger homeodomain inactivated interferes ligase loop preferentially proline siah2 stimulates switch termination ubiquitin ubiquitination uncovers waf1 xaf1 xiap zinc znf313	box capable closely coding colony colorectal contributed crc diverse elucidated forkhead foxo1 foxo3a inducible intensity luciferase messenger micrornas mir mirna mirnabased mirnas mtt o1 overexpressed reporter upregulated utrs viability
Tagcloud (Difference) ?		adding complexity decisions determines e3 fail fate favoring feedback finger homeodomain inactivated interferes ligase loop preferentially proline siah2 stimulates switch termination ubiquitin ubiquitination uncovers waf1 xaf1 xiap zinc znf313	box capable closely coding colony colorectal contributed crc diverse elucidated forkhead foxo1 foxo3a inducible intensity luciferase messenger micrornas mir mirna mirnabased mirnas mtt o1 overexpressed reporter upregulated utrs viability
Tagcloud (Intersection) ?