Wiki-Pi
Answer Survey
Home
About
Help
Advanced Search
HIPK2 and NKX2-5
Number of citations of the paper that reports this interaction (PMID
9748262
)
47
Data Source:
HPRD
(in vitro, two hybrid)
HIPK2
NKX2-5
Gene Name
homeodomain interacting protein kinase 2
NK2 homeobox 5
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Nuclear Body
PML Body
RNA Polymerase II Transcription Factor Complex
Nucleus
Transcription Factor Complex
Cytoplasm
RNA Polymerase II Transcription Factor Complex
Molecular Function
RNA Polymerase II Activating Transcription Factor Binding
RNA Polymerase II Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
SMAD Binding
Virion Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
RNA Polymerase II Transcription Cofactor Activity
RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
DNA Binding
Chromatin Binding
Sequence-specific DNA Binding Transcription Factor Activity
RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Serum Response Element Binding
Protein Homodimerization Activity
Sequence-specific DNA Binding
Transcription Regulatory Region DNA Binding
Protein Heterodimerization Activity
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Eye Development
Positive Regulation Of Protein Phosphorylation
Transcription, DNA-templated
Protein Phosphorylation
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
Transforming Growth Factor Beta Receptor Signaling Pathway
Smoothened Signaling Pathway
Adult Walking Behavior
Positive Regulation Of Cell Proliferation
Anterior/posterior Pattern Specification
Retina Layer Formation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Modulation By Virus Of Host Morphology Or Physiology
Neuron Differentiation
Erythrocyte Differentiation
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
PML Body Organization
Positive Regulation Of Protein Binding
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of DNA Binding
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of JNK Cascade
Embryonic Camera-type Eye Morphogenesis
Voluntary Musculoskeletal Movement
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Cell Cycle
Embryonic Retina Morphogenesis In Camera-type Eye
Lens Induction In Camera-type Eye
SMAD Protein Signal Transduction
Iris Morphogenesis
Cellular Response To Hypoxia
Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Vasculogenesis
Heart Looping
Heart Morphogenesis
Outflow Tract Septum Morphogenesis
Cardiac Conduction System Development
Bundle Of His Development
Purkinje Myocyte Differentiation
Cardiac Ventricle Formation
Right Ventricular Cardiac Muscle Tissue Morphogenesis
Ventricular Trabecula Myocardium Morphogenesis
Apoptotic Process Involved In Heart Morphogenesis
Septum Secundum Development
Proepicardium Development
Pulmonary Myocardium Development
Transcription From RNA Polymerase II Promoter
Adult Heart Development
Positive Regulation Of Cell Proliferation
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Transcription Via Serum Response Element Binding
Positive Regulation Of Sodium Ion Transport
Negative Regulation Of Myotube Differentiation
Hemopoiesis
Cell Differentiation
BMP Signaling Pathway
Thyroid Gland Development
Embryonic Heart Tube Development
Negative Regulation Of Apoptotic Process
Sarcomere Organization
Positive Regulation Of Neuron Differentiation
Positive Regulation Of Heart Contraction
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Spleen Development
Positive Regulation Of Cardioblast Differentiation
Ventricular Cardiac Myofibril Assembly
Cardiac Muscle Cell Differentiation
Cardiac Muscle Tissue Morphogenesis
Atrial Cardiac Muscle Cell Development
Ventricular Cardiac Muscle Cell Development
Regulation Of Cardiac Muscle Contraction
Pharyngeal System Development
Cardiac Muscle Cell Proliferation
Regulation Of Cardiac Muscle Cell Proliferation
Cardiac Muscle Contraction
Canonical Wnt Signaling Pathway
Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Heart Trabecula Formation
Ventricular Septum Morphogenesis
Atrial Septum Morphogenesis
Atrioventricular Node Cell Development
Atrioventricular Node Cell Fate Commitment
Embryonic Heart Tube Left/right Pattern Formation
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Voltage-gated Calcium Channel Activity
Pathways
Generic Transcription Pathway
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Generic Transcription Pathway
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Drugs
Diseases
GWAS
Heart rate (
23583979
)
Infantile hypertrophic pyloric stenosis (
22306654
)
PR interval (
20062060
)
Protein-Protein Interactions
48 interactors:
AATF
BTRC
CHMP4B
CREBBP
CUL1
CXCL1
DAXX
DDX39A
DDX39B
EP300
FBXW7
HIST2H2BE
HMGA1
KAT2B
MAP3K7
MBP
MDM2
MECP2
MKNK1
MYB
MYBL1
NKX2-1
NKX2-5
NKX3-1
NLK
PAX6
PML
PTCH1
RANBP9
RUNX1
SENP1
SIAH1
SIAH2
SKI
SMAD1
SMAD2
SMAD3
SP100
SUMO1
SUMO2
TP53
TP53INP1
TP63
TP73
TRADD
UBE2I
WSB1
ZBTB4
13 interactors:
CAMTA2
CSNK2A1
FOXH1
GATA4
HDAC1
HIPK1
HIPK2
JARID2
KDM6A
SRF
TBX2
TBX5
TLE1
Entrez ID
28996
1482
HPRD ID
06039
02787
Ensembl ID
ENSG00000064393
ENSG00000183072
Uniprot IDs
Q9H2X6
P52952
PDB IDs
3RKQ
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Positive Regulation Of Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Gene Expression
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transcription, DNA-templated
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Viral Process
Response To Organic Substance
Apoptotic Process
Transcription, DNA-templated
Cellular Response To Organic Substance
Tube Development
Regulation Of Signaling
Programmed Cell Death
Positive Regulation Of Transcription From RNA Polymerase II Promoter
RNA Biosynthetic Process
Regulation Of Cell Death
Regulation Of Protein Metabolic Process
Response To Stimulus
Cell Death
Death
Regulation Of Signal Transduction
Negative Regulation Of Cell Proliferation
Regulation Of Apoptotic Process
Regulation Of Cell Proliferation
Cell Cycle
RNA Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Transcription From RNA Polymerase II Promoter
Cell Cycle Process
Regulation Of Cell Cycle
Cell Communication
Gene Expression
Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Signaling Pathway
Organ Morphogenesis
Embryonic Morphogenesis
Transcription, DNA-templated
RNA Biosynthetic Process
Embryonic Organ Morphogenesis
Tissue Morphogenesis
Anatomical Structure Formation Involved In Morphogenesis
RNA Metabolic Process
Embryo Development
Anatomical Structure Morphogenesis
Heart Morphogenesis
Gene Expression
Regulation Of Gene Expression
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Macromolecule Biosynthetic Process
Pattern Specification Process
Anterior/posterior Pattern Specification
Embryonic Organ Development
Macromolecule Biosynthetic Process
Regulation Of Cell Proliferation
Cardiac Chamber Development
Organ Development
System Development
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Tissue Development
Cardiac Muscle Tissue Development
Multicellular Organismal Development
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Anatomical Structure Development
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Growth
Positive Regulation Of Cell Proliferation
Cellular Nitrogen Compound Metabolic Process
Transcription From RNA Polymerase II Promoter
Heart Development
Developmental Process
Nitrogen Compound Metabolic Process
Positive Regulation Of Gene Expression
Aorta Morphogenesis
Regulation Of Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cardiac Muscle Cell Proliferation
Aorta Development
Striated Muscle Tissue Development
Tagcloud
?
adding
complexity
decisions
determines
e3
fail
fate
favoring
feedback
finger
homeodomain
inactivated
interferes
ligase
loop
preferentially
proline
siah2
stimulates
switch
termination
ubiquitin
ubiquitination
uncovers
waf1
xaf1
xiap
zinc
znf313
Tagcloud (Difference)
?
adding
complexity
decisions
determines
e3
fail
fate
favoring
feedback
finger
homeodomain
inactivated
interferes
ligase
loop
preferentially
proline
siah2
stimulates
switch
termination
ubiquitin
ubiquitination
uncovers
waf1
xaf1
xiap
zinc
znf313
Tagcloud (Intersection)
?