PPFIA2 and CDC5L

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		PPFIA2	CDC5L
Gene Name		protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	cell division cycle 5-like
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Cell Surface Presynaptic Active Zone Extracellular Vesicular Exosome	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Nucleolus Cytoplasm Membrane Nuclear Speck Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding Protein Complex Binding	DNA Binding Chromatin Binding Protein Binding Poly(A) RNA Binding WD40-repeat Domain Binding
	Biological Process	Cell-matrix Adhesion Synaptic Transmission Neurotransmitter Secretion Glutamate Secretion	MRNA Splicing, Via Spliceosome DNA Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated RNA Splicing Gene Expression Signal Transduction Involved In DNA Damage Checkpoint
Pathways		Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Schizophrenia ( 22885689)	Osteoarthritis ( 22763110) Stroke (ischemic) ( 22941190)
Protein-Protein Interactions		13 interactors: CAST CDC5L ERC2 GIT1 ITSN1 PPFIA1 PPFIA3 PPFIBP1 PPFIBP2 PTPRD PTPRF PTPRG PTPRS	69 interactors: AKAP6 AKAP9 BCAS2 CALM1 CCDC136 CDK2 CDKN1A CDKN2A CDT1 CTNNBL1 DISC1 DIXDC1 DST EMID1 ERG EXOC1 EXOC7 GLTSCR1L GOLGA2 GOLGA8EP GOLGA8F GRB14 GSE1 HOOK1 KALRN KANSL1 KDM1A KIF3C KIF5B KRT18 LMO2 MACF1 MCM10 MCM3 MCM4 MCM5 MELK MYT1L ORC1 ORC2 ORC5 PCBD2 PDE4DIP PLRG1 PPFIA2 PPP1CA PPP1R13B PPP1R8 PRPF19 PRPF3 RPA1 RPA2 RPA3 SFR1 SH3BP5 SMARCD1 SPTBN1 SYNE1 TRAF3IP1 TRAK1 TRIO TTF2 WWC1 YWHAG YWHAQ YWHAZ ZNF35 ZNF451 ZSCAN1
Entrez ID		8499	988
HPRD ID		04392	04184
Ensembl ID		ENSG00000139220	ENSG00000096401
Uniprot IDs		G3V200 O75334	Q99459
PDB IDs		3TAC 3TAD	2DIM 2DIN
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Dephosphorylation Enzyme Linked Receptor Protein Signaling Pathway Protein Dephosphorylation Signaling Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Cell Communication Dephosphorylation Signal Transduction Glutamate Secretion Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Stimulus Acid Secretion Dicarboxylic Acid Transport Ephrin Receptor Signaling Pathway Neurotransmitter Secretion Cell Surface Receptor Signaling Pathway Response To Stimulus Regulation Of Neurotransmitter Levels Synaptic Transmission Nervous System Development Amino Acid Transport Neurotransmitter Transport Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Receptor Binding Presynaptic Membrane Assembly Generation Of Neurons Negative Regulation Of Stress Fiber Assembly Presynaptic Membrane Organization Neurogenesis Negative Regulation Of Actin Filament Bundle Assembly Regulation Of Short-term Neuronal Synaptic Plasticity Regulation Of Cellular Process Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Cell-cell Signaling	Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Cell Cycle Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Replication Initiation Organelle Organization Cellular Process DNA Recombinase Assembly Apoptotic Signaling Pathway DNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Potassium Ion Transport Cellular Localization Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Cell Cycle Intracellular Signal Transduction Nitrogen Compound Metabolic Process Positive Regulation Of Cell Death Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Metabolic Process Establishment Of Localization In Cell Intrinsic Apoptotic Signaling Pathway Nucleotide-excision Repair, DNA Gap Filling Positive Regulation Of Potassium Ion Transmembrane Transport G2/M Transition Of Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal Regulation Of Intracellular Transport Negative Regulation Of Cell Cycle Positive Regulation Of Apoptotic Process Telomere Maintenance Via Semi-conservative Replication Regulation Of Potassium Ion Transport Cellular Response To Heat Regulation Of Membrane Repolarization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Cell Cycle Phase Transition RNA Splicing Telomere Maintenance Via Recombination Nuclear DNA Replication Golgi To Plasma Membrane Protein Transport
Tagcloud ?			adjuvant adolescents analyse barcodes cdk4 determining digital encoded helicase histopathologic inactivator malignancy mdm2 nanostring neo networks operative osteosarcoma osteosarcomas paediatric panel quantify rb1 recql4 responded runx2 sporadic tp53 unfavourable
Tagcloud (Difference) ?			adjuvant adolescents analyse barcodes cdk4 determining digital encoded helicase histopathologic inactivator malignancy mdm2 nanostring neo networks operative osteosarcoma osteosarcomas paediatric panel quantify rb1 recql4 responded runx2 sporadic tp53 unfavourable
Tagcloud (Intersection) ?