GRB14 and SQSTM1

Number of citations of the paper that reports this interaction (PMID 12242277)
10

Data Source:
HPRD (in vivo)

		GRB14	SQSTM1
Gene Name		growth factor receptor-bound protein 14	sequestosome 1
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytoplasm Cytosol Plasma Membrane Endosome Membrane Intracellular Membrane-bounded Organelle	Pre-autophagosomal Structure Cytoplasmic MRNA Processing Body Nucleoplasm Cytoplasm Lysosome Late Endosome Autophagic Vacuole Endoplasmic Reticulum Cytosol Inclusion Body Aggresome PML Body Cytoplasmic Vesicle Extracellular Vesicular Exosome
	Molecular Function	SH3/SH2 Adaptor Activity	Protein Serine/threonine Kinase Activity Protein Kinase C Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding SH2 Domain Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding K63-linked Polyubiquitin Binding
	Biological Process	Signal Transduction Blood Coagulation Positive Regulation Of Signal Transduction Leukocyte Migration	Positive Regulation Of Protein Phosphorylation Immune System Process Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Autophagy Response To Stress Protein Localization Endosomal Transport Macroautophagy Positive Regulation Of Macroautophagy Cell Differentiation Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Ras Protein Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Protein Heterooligomerization Apoptotic Signaling Pathway
Pathways		Tie2 Signaling Cell surface interactions at the vascular wall	Signaling by Interleukins Signalling by NGF NF-kB is activated and signals survival p75NTR recruits signalling complexes Cell death signalling via NRAGE, NRIF and NADE NRIF signals cell death from the nucleus p75NTR signals via NF-kB Cytokine Signaling in Immune system Interleukin-1 signaling p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		Blood pressure ( 21572416) Fasting insulin-related traits (interaction with BMI) ( 22581228) Response to statin therapy ( 20339536) Type 2 diabetes ( 21874001) Waist-hip ratio ( 20935629)
Protein-Protein Interactions		14 interactors: CDC5L DAPK3 EGFR FGFR1 IGF1R INSR IRS1 MAP3K14 PDGFRA PDGFRB PRKCZ SQSTM1 TEK TNKS2	74 interactors: ATXN3 BCL2 BMPR1B BPTF CALM1 CAMK2A CCNB1 CDC37 CDK1 CSNK2A1 DAZAP2 EEF1D EGLN3 FKBP4 GABARAPL1 GABARAPL2 GABRR1 GABRR2 GEMIN4 GRB14 GRIA1 GRIA2 GRIA3 IRAK1 KCNAB2 KEAP1 LCK LINC00341 MALT1 MAP1LC3A MAP1LC3B MAP2K5 MAP3K3 MAPK14 MBP MEIS2 MLH1 NBR1 NCOR1 NR2F2 NTRK1 NTRK2 NTRK3 OPTN PAWR PIK3CA PPHLN1 PRKCI PRKCZ RAD23A RELN RIPK1 RPL37 SMAD1 SMAD2 SMAD3 SMAD4 SMURF1 SNCA STXBP1 TGFBR1 TKT TOE1 TP53 TRAF6 TRIM55 TRIM63 TTN UBA52 UBB UBC ULK1 ULK2 YWHAZ
Entrez ID		2888	8878
HPRD ID		03313	03319
Ensembl ID		ENSG00000115290	ENSG00000161011
Uniprot IDs		B7Z7F9 Q14449	Q13501
PDB IDs		2AUG 2AUH 4K81	1Q02 2JY7 2JY8 2K0B 2KNV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Intracellular Signal Transduction Protein Autophosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Positive Regulation Of Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorylation Positive Regulation Of Cell Motility Protein Phosphorylation Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of MAPK Cascade Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Peptidyl-tyrosine Phosphorylation Phosphatidylinositol-mediated Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation Positive Regulation Of DNA Metabolic Process Phosphorylation Positive Regulation Of Cellular Metabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Phospholipase Activity Positive Regulation Of DNA Replication Regulation Of Cell Migration Response To Growth Factor Regulation Of Phospholipase Activity Regulation Of Cell Motility Positive Regulation Of Lipase Activity Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Locomotion Regulation Of Cellular Component Movement Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Protein Phosphorylation Neurotrophin Signaling Pathway Signaling Cell Communication Cellular Protein Modification Process Cellular Response To Organonitrogen Compound Regulation Of Intracellular Signal Transduction Response To Organonitrogen Compound Response To Organic Substance	Cell Communication Response To Growth Factor Cellular Response To Growth Factor Stimulus Cellular Response To Stimulus Response To Stimulus Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Response To Stress Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Kinase Activity Phosphorylation Cellular Response To Organic Substance Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Signal Transduction Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Transferase Activity Positive Regulation Of Kinase Activity Regulation Of Cell Death Negative Regulation Of Cell Death Response To Organic Substance Regulation Of Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Cellular Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Metabolic Process Protein Phosphorylation Activation Of Protein Kinase Activity Membrane Organization Neurotrophin TRK Receptor Signaling Pathway Cellular Component Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway Cellular Response To Stress
Tagcloud ?		adapter appears avidly bear bps conversely denote domain domains dramatically existence grb10 grb7 homology interact interaction interacts ir location loop obvious paired pleckstrin resemblance sh2 summary unidentified y1150f y1151f	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 warranted wnt1
Tagcloud (Difference) ?		adapter appears avidly bear bps conversely denote domain domains dramatically existence grb10 grb7 homology interact interaction interacts ir location loop obvious paired pleckstrin resemblance sh2 summary unidentified y1150f y1151f	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 warranted wnt1
Tagcloud (Intersection) ?