GRB14

Gene Name		growth factor receptor-bound protein 14
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytoplasm Cytosol Plasma Membrane Endosome Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	SH3/SH2 Adaptor Activity
	Biological Process	Signal Transduction Blood Coagulation Positive Regulation Of Signal Transduction Leukocyte Migration
Pathways		Tie2 Signaling Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Blood pressure ( 21572416) Fasting insulin-related traits (interaction with BMI) ( 22581228) Response to statin therapy ( 20339536) Type 2 diabetes ( 21874001) Waist-hip ratio ( 20935629)
Protein-protein Interactions		14 interactors: CDC5L DAPK3 EGFR FGFR1 IGF1R INSR IRS1 MAP3K14 PDGFRA PDGFRB PRKCZ SQSTM1 TEK TNKS2
Entrez ID		2888
HPRD ID		03313
Ensembl ID		ENSG00000115290
Uniprot IDs		B7Z7F9 Q14449
PDB IDs		2AUG 2AUH 4K81
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Intracellular Signal Transduction Protein Autophosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Positive Regulation Of Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorylation Positive Regulation Of Cell Motility Protein Phosphorylation Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of MAPK Cascade Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Peptidyl-tyrosine Phosphorylation Phosphatidylinositol-mediated Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation Positive Regulation Of DNA Metabolic Process Phosphorylation Positive Regulation Of Cellular Metabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Phospholipase Activity Positive Regulation Of DNA Replication Regulation Of Cell Migration Response To Growth Factor Regulation Of Phospholipase Activity Regulation Of Cell Motility Positive Regulation Of Lipase Activity Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Locomotion Regulation Of Cellular Component Movement Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Protein Phosphorylation Neurotrophin Signaling Pathway Signaling Cell Communication Cellular Protein Modification Process Cellular Response To Organonitrogen Compound Regulation Of Intracellular Signal Transduction Response To Organonitrogen Compound Response To Organic Substance
Tagcloud ?		adapter appears avidly bear bps conversely denote domain domains dramatically existence grb10 grb7 homology interact interaction interacts ir location loop obvious paired pleckstrin resemblance sh2 summary unidentified y1150f y1151f