GRB14 and PRKCZ

Number of citations of the paper that reports this interaction (PMID 12242277)
10

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		GRB14	PRKCZ
Gene Name		growth factor receptor-bound protein 14	protein kinase C, zeta
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytoplasm Cytosol Plasma Membrane Endosome Membrane Intracellular Membrane-bounded Organelle	Nuclear Envelope Cytoplasm Endosome Microtubule Organizing Center Cytosol Plasma Membrane Cell-cell Junction Tight Junction Membrane Apical Plasma Membrane Nuclear Matrix Cell Junction Cell Leading Edge Filamentous Actin Myelin Sheath Abaxonal Region Axon Hillock Membrane Raft Apical Cortex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	SH3/SH2 Adaptor Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Protein Kinase Binding Protein Domain Specific Binding Phospholipase Binding Insulin Receptor Substrate Binding Metal Ion Binding 14-3-3 Protein Binding
	Biological Process	Signal Transduction Blood Coagulation Positive Regulation Of Signal Transduction Leukocyte Migration	Microtubule Cytoskeleton Organization Positive Regulation Of Cell-matrix Adhesion Protein Phosphorylation Inflammatory Response Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Blood Coagulation Long-term Memory Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Cell Migration Peptidyl-serine Phosphorylation Establishment Of Cell Polarity Platelet Activation Negative Regulation Of Protein Complex Assembly Actin Cytoskeleton Reorganization Activation Of Phospholipase D Activity Activation Of Protein Kinase B Activity Positive Regulation Of Interleukin-4 Production Negative Regulation Of Apoptotic Process Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Insulin Receptor Signaling Pathway Vesicle Transport Along Microtubule Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Heterooligomerization Negative Regulation Of Hydrolase Activity Membrane Hyperpolarization Long-term Synaptic Potentiation Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase C Signaling Protein Localization To Plasma Membrane Neuron Projection Extension Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of Interleukin-5 Secretion Positive Regulation Of Interleukin-13 Secretion Positive Regulation Of Interleukin-10 Secretion
Pathways		Tie2 Signaling Cell surface interactions at the vascular wall	Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Signaling by VEGF GPVI-mediated activation cascade Platelet activation, signaling and aggregation SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Blood pressure ( 21572416) Fasting insulin-related traits (interaction with BMI) ( 22581228) Response to statin therapy ( 20339536) Type 2 diabetes ( 21874001) Waist-hip ratio ( 20935629)	Height ( 20881960) Reasoning ( 21107309)
Protein-Protein Interactions		14 interactors: CDC5L DAPK3 EGFR FGFR1 IGF1R INSR IRS1 MAP3K14 PDGFRA PDGFRB PRKCZ SQSTM1 TEK TNKS2	84 interactors: ADAP1 ADCY5 AFAP1 AKT1 AKT3 BTK C1QBP CASP3 CASP6 CASP7 CASP8 CASP9 CCDC115 CDC42 CHAT CSNK2B DAPK3 DENND5A FADD FEZ1 FEZ2 FRS2 FYN GLRX3 GRB14 GRM5 GSK3A GSK3B HABP4 HIST1H1A HIST1H1B HIST3H3 HRAS IKBKB IL4R IRAK1 IRS1 IRS4 JAK1 KRT10 LRRK2 MAP2K1 MAP2K5 MAPK1 MAPK3 MAPK7 MARCKS MBP NCF1 NCL NCOA3 NFATC2 NMT2 NUMB PARD6A PARD6B PARD6G PAWR PDLIM7 PDPK1 PEBP1 PPP1R14A PPP3CA PRG2 PRKCA PRKCD PSEN1 RAF1 RELA RHOA SLC39A1 SP1 SQSTM1 SRC STAT6 STUB1 TIAM1 TRAF6 UTP14A WWC1 YWHAB YWHAQ YWHAZ ZNF71
Entrez ID		2888	5590
HPRD ID		03313	01504
Ensembl ID		ENSG00000115290	ENSG00000067606
Uniprot IDs		B7Z7F9 Q14449	Q05513
PDB IDs		2AUG 2AUH 4K81
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Intracellular Signal Transduction Protein Autophosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Positive Regulation Of Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorylation Positive Regulation Of Cell Motility Protein Phosphorylation Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of MAPK Cascade Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Peptidyl-tyrosine Phosphorylation Phosphatidylinositol-mediated Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation Positive Regulation Of DNA Metabolic Process Phosphorylation Positive Regulation Of Cellular Metabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Phospholipase Activity Positive Regulation Of DNA Replication Regulation Of Cell Migration Response To Growth Factor Regulation Of Phospholipase Activity Regulation Of Cell Motility Positive Regulation Of Lipase Activity Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Locomotion Regulation Of Cellular Component Movement Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Protein Phosphorylation Neurotrophin Signaling Pathway Signaling Cell Communication Cellular Protein Modification Process Cellular Response To Organonitrogen Compound Regulation Of Intracellular Signal Transduction Response To Organonitrogen Compound Response To Organic Substance	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Innate Immune Response Immune Response Immune Response-regulating Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Defense Response Fc Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Metabolic Process Immune System Process Positive Regulation Of Signal Transduction Regulation Of Immune System Process Signaling Fc-epsilon Receptor Signaling Pathway Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Cell Communication Apoptotic Signaling Pathway Response To Organic Substance Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Cell Death Cellular Response To Fibroblast Growth Factor Stimulus Death Apoptotic Process Response To Fibroblast Growth Factor Vascular Endothelial Growth Factor Receptor Signaling Pathway Programmed Cell Death Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Cell Death Positive Regulation Of Metabolic Process Response To Stress Regulation Of Protein Metabolic Process Response To External Stimulus Regulation Of Intracellular Signal Transduction Regulation Of Kinase Activity Positive Regulation Of Catalytic Activity
Tagcloud ?		adapter appears avidly bear bps conversely denote domain domains dramatically existence grb10 grb7 homology interact interaction interacts ir location loop obvious paired pleckstrin resemblance sh2 summary unidentified y1150f y1151f	apical blastocyst cdx2 compaction dampened derives erm gtpases hippo icm lats1 lineages llgl1 nanog outer pard6b phosphorylating polarity polarization rho rock scrib segregation specification specifying te trophectoderm tyrosinated yap
Tagcloud (Difference) ?		adapter appears avidly bear bps conversely denote domain domains dramatically existence grb10 grb7 homology interact interaction interacts ir location loop obvious paired pleckstrin resemblance sh2 summary unidentified y1150f y1151f	apical blastocyst cdx2 compaction dampened derives erm gtpases hippo icm lats1 lineages llgl1 nanog outer pard6b phosphorylating polarity polarization rho rock scrib segregation specification specifying te trophectoderm tyrosinated yap
Tagcloud (Intersection) ?