GRB14 and DAPK3

Number of citations of the paper that reports this interaction (PubMedID 12242277)
72

Data Source:
BioGRID (pull down)

		GRB14	DAPK3
Description		growth factor receptor bound protein 14	death associated protein kinase 3
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Plasma Membrane Endosome Membrane Membrane	Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Cilium PML Body Midbody
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Receptor Tyrosine Kinase Binding Molecular Adaptor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding CAMP Response Element Binding Protein Binding Kinase Activity Transferase Activity Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity Leucine Zipper Domain Binding Protein Serine Kinase Activity
	Biological Process	Signal Transduction Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway	Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Translation Protein Phosphorylation Apoptotic Process Regulation Of Smooth Muscle Contraction Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Regulation Of Cell Shape Regulation Of Autophagy Negative Regulation Of Translation Positive Regulation Of Cell Migration Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Myosin II Filament Organization Protein Autophosphorylation Regulation Of Focal Adhesion Assembly Cellular Response To Type II Interferon Positive Regulation Of Canonical Wnt Signaling Pathway Apoptotic Signaling Pathway Regulation Of Cell Motility
Pathways		Tie2 Signaling	Caspase activation via Dependence Receptors in the absence of ligand
Drugs			2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one 4-(6-{[(1R)-1-(hydroxymethyl)propyl]amino}imidazo[1,2-b]pyridazin-3-yl)benzoic acid (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile Fostamatinib
Diseases
GWAS		A body shape index ( 34021172) Adventurousness ( 30643258) Blood pressure ( 21572416 24954895) Body fat percentage ( 31453325 26833246) Body fat percentage variance ( 31453325) Body mass index ( 26426971 29381148) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Coronary artery disease ( 33020668 32469254) Diastolic blood pressure ( 27618452 28739976) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Fasting blood insulin ( 25631608) Fasting blood insulin (BMI interaction) ( 22581228) Glomerular filtration rate in chronic kidney disease ( 26420894) Glycine levels ( 30837465) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 33339817) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412) Hip index ( 34021172) Hypertension ( 30487518) Immunoglobulin A vasculitis ( 28698626) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Mean arterial pressure ( 30487518 29403010) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Myocardial infarction ( 33532862) Number of sexual partners ( 30643258) Perceived sweetness of sucrose ( 31005972) Pulse pressure ( 27841878 28739976 30487518) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Response to statin therapy ( 20339536) Sexual dimorphism in anthropometric traits ( 23754948) Systolic blood pressure ( 28739976 26390057 27618447 29403010 27618452 27841878 28135244) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Triglyceride levels ( 32203549 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Type 2 diabetes ( 30718926 21874001 22885922 28869590 24509480 32499647 30297969 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 25673412 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 20935629 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in inactive individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412)	Age-related macular degeneration ( 23326517) Expressive vocabulary in infants ( 25226531)
Interacting Genes		25 interacting genes: CDC5L CHFR DAPK3 EGFR ERBB2 FGFR1 FRS3 GIGYF1 GIGYF2 GOLGA2 HCK IGF1R INSR IRS1 MAP3K14 MET PDGFRA PDGFRB PRKCZ SQSTM1 STK26 TEK TNKS2 TRIM27 TRIM55	18 interacting genes: AATF AK3 ANXA1 ATF4 CDKN1A CHEK2 DAXX GRB14 LMO7 MDM2 MET NEDD4L OGT PAWR PRKCZ RPL34 TCP10L TP53
Entrez ID		2888	1613
HPRD ID		03313	04478
Ensembl ID		ENSG00000115290	ENSG00000167657
Uniprot IDs		Q14449	B3KNJ3 O43293
PDB IDs		2AUG 2AUH 4K81	1YRP 2J90 3BHY 3BQR 5A6N 5A6O 5VJA
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Activity Protein Tyrosine Kinase Activity Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Transferase Activity Signal Transduction Protein Autophosphorylation Receptor Complex Protein Phosphorylation Protein Modification Process Phosphorylation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Signaling Pathway ATP Binding Nucleotide Binding Identical Protein Binding Regulation Of Cellular Component Organization Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MAPK Cascade Insulin Receptor Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Migration Positive Regulation Of Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Insulin-like Growth Factor Receptor Signaling Pathway Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Cell Population Proliferation Regulation Of Organelle Organization Regulation Of Signal Transduction Regulation Of Cell Migration Insulin Receptor Substrate Binding Regulation Of Cell Motility Regulation Of Intracellular Signal Transduction Regulation Of Locomotion Phosphatidylinositol 3-kinase Binding Positive Regulation Of Cellular Component Organization Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Basal Plasma Membrane Regulation Of Programmed Cell Death Regulation Of ERK1 And ERK2 Cascade	Regulation Of Programmed Cell Death Cellular Response To Gamma Radiation Leucine Zipper Domain Binding DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Gamma Radiation Negative Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Radiation Negative Regulation Of Cell Communication Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Replicative Senescence Cellular Response To Ionizing Radiation Cellular Response To UV Molecular Function Activator Activity Positive Regulation Of Metabolic Process Cellular Response To Actinomycin D Signal Transduction By P53 Class Mediator Regulation Of Apoptotic Process Cellular Response To Light Stimulus Cellular Response To Nutrient Levels Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To Actinomycin D Response To Nutrient Levels Negative Regulation Of Gene Expression Regulation Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Cellular Response To UV-C Ubiquitin Protein Ligase Binding Response To Ionizing Radiation Positive Regulation Of Biosynthetic Process Positive Regulation Of Programmed Cell Death Regulation Of Macromolecule Biosynthetic Process Signal Transduction In Response To DNA Damage Response To UV Negative Regulation Of Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process Negative Regulation Of Protein Metabolic Process Stress-induced Premature Senescence Regulation Of Signaling Negative Regulation Of Biosynthetic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition
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