GRB14 and DAPK3

Number of citations of the paper that reports this interaction (PMID 12242277)
10

Data Source:
BioGRID (pull down)

		GRB14	DAPK3
Gene Name		growth factor receptor-bound protein 14	death-associated protein kinase 3
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytoplasm Cytosol Plasma Membrane Endosome Membrane Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm PML Body Membrane Raft
	Molecular Function	SH3/SH2 Adaptor Activity	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding ATP Binding Rho GTPase Binding Identical Protein Binding Protein Homodimerization Activity Leucine Zipper Domain Binding
	Biological Process	Signal Transduction Blood Coagulation Positive Regulation Of Signal Transduction Leukocyte Migration	Cytokinesis Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Regulation Of Smooth Muscle Contraction Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Regulation Of Cell Shape Regulation Of Autophagy Chromatin Modification Negative Regulation Of Translation Neuron Differentiation Positive Regulation Of Cell Migration Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Myosin II Filament Organization Protein Autophosphorylation Regulation Of Focal Adhesion Assembly Cellular Response To Interferon-gamma Positive Regulation Of Canonical Wnt Signaling Pathway Apoptotic Signaling Pathway Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Tie2 Signaling Cell surface interactions at the vascular wall	Programmed Cell Death Role of DCC in regulating apoptosis Extrinsic Pathway
Drugs
Diseases
GWAS		Blood pressure ( 21572416) Fasting insulin-related traits (interaction with BMI) ( 22581228) Response to statin therapy ( 20339536) Type 2 diabetes ( 21874001) Waist-hip ratio ( 20935629)	Age-related macular degeneration ( 23326517)
Protein-Protein Interactions		14 interactors: CDC5L DAPK3 EGFR FGFR1 IGF1R INSR IRS1 MAP3K14 PDGFRA PDGFRB PRKCZ SQSTM1 TEK TNKS2	15 interactors: AATF AK3 ATF4 CDKN1A CHEK2 DAXX GRB14 MDM2 MET NEDD4L PAWR PRKCZ RPL34 TCP10L TP53
Entrez ID		2888	1613
HPRD ID		03313	04478
Ensembl ID		ENSG00000115290	ENSG00000167657
Uniprot IDs		B7Z7F9 Q14449	O43293
PDB IDs		2AUG 2AUH 4K81	1YRP 2J90 3BHY 3BQR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Intracellular Signal Transduction Protein Autophosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Positive Regulation Of Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorylation Positive Regulation Of Cell Motility Protein Phosphorylation Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of MAPK Cascade Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Peptidyl-tyrosine Phosphorylation Phosphatidylinositol-mediated Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation Positive Regulation Of DNA Metabolic Process Phosphorylation Positive Regulation Of Cellular Metabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Phospholipase Activity Positive Regulation Of DNA Replication Regulation Of Cell Migration Response To Growth Factor Regulation Of Phospholipase Activity Regulation Of Cell Motility Positive Regulation Of Lipase Activity Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Locomotion Regulation Of Cellular Component Movement Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Protein Phosphorylation Neurotrophin Signaling Pathway Signaling Cell Communication Cellular Protein Modification Process Cellular Response To Organonitrogen Compound Regulation Of Intracellular Signal Transduction Response To Organonitrogen Compound Response To Organic Substance	Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Death Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Response To Stress Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Apoptotic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Death Positive Regulation Of Programmed Cell Death Response To Growth Factor Positive Regulation Of Cell Death Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process DNA Damage Checkpoint Positive Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Checkpoint Positive Regulation Of Protein Phosphorylation RNA Biosynthetic Process Signal Transduction Regulation Of Mitotic Cell Cycle Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Intrinsic Apoptotic Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of RNA Metabolic Process Cellular Response To UV Negative Regulation Of Gene Expression Positive Regulation Of Protein Kinase Activity Signaling Positive Regulation Of Phosphorylation Cellular Response To Extracellular Stimulus Cell Communication Positive Regulation Of Kinase Activity
Tagcloud ?		adapter appears avidly bear bps conversely denote domain domains dramatically existence grb10 grb7 homology interact interaction interacts ir location loop obvious paired pleckstrin resemblance sh2 summary unidentified y1150f y1151f	3d accelerated acinar acini actively augmented constitutive dcis depleted enlarged epistatic epithelia exerts gaps knockout lacks lentiviral morphogenesis mtorc1 oncomine polarity raptor shed spatio suppressive threonine uniquely utilizing vital
Tagcloud (Difference) ?		adapter appears avidly bear bps conversely denote domain domains dramatically existence grb10 grb7 homology interact interaction interacts ir location loop obvious paired pleckstrin resemblance sh2 summary unidentified y1150f y1151f	3d accelerated acinar acini actively augmented constitutive dcis depleted enlarged epistatic epithelia exerts gaps knockout lacks lentiviral morphogenesis mtorc1 oncomine polarity raptor shed spatio suppressive threonine uniquely utilizing vital
Tagcloud (Intersection) ?