GRB14 and STK26

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		GRB14	STK26
Description		growth factor receptor bound protein 14	serine/threonine kinase 26
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Plasma Membrane Endosome Membrane Membrane	Cytoplasm Golgi Apparatus Golgi-associated Vesicle Cytosol Vesicle Membrane Membrane Apical Plasma Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery FAR/SIN/STRIPAK Complex
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Receptor Tyrosine Kinase Binding Molecular Adaptor Activity	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Signal Transduction Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway	Protein Phosphorylation Apoptotic Process Cellular Response To Starvation Negative Regulation Of Cell Migration Cellular Response To Oxidative Stress Intracellular Signal Transduction Regulation Of Apoptotic Process Protein Autophosphorylation Positive Regulation Of Microvillus Assembly
Pathways		Tie2 Signaling	Apoptotic cleavage of cellular proteins
Drugs			2-[4-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]iminocyclohexa-2,5-dien-1-yl]acetonitrile Fostamatinib
Diseases
GWAS		A body shape index ( 34021172) Adventurousness ( 30643258) Blood pressure ( 21572416 24954895) Body fat percentage ( 31453325 26833246) Body fat percentage variance ( 31453325) Body mass index ( 26426971 29381148) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Coronary artery disease ( 33020668 32469254) Diastolic blood pressure ( 27618452 28739976) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Fasting blood insulin ( 25631608) Fasting blood insulin (BMI interaction) ( 22581228) Glomerular filtration rate in chronic kidney disease ( 26420894) Glycine levels ( 30837465) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 33339817) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412) Hip index ( 34021172) Hypertension ( 30487518) Immunoglobulin A vasculitis ( 28698626) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Mean arterial pressure ( 30487518 29403010) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Myocardial infarction ( 33532862) Number of sexual partners ( 30643258) Perceived sweetness of sucrose ( 31005972) Pulse pressure ( 27841878 28739976 30487518) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Response to statin therapy ( 20339536) Sexual dimorphism in anthropometric traits ( 23754948) Systolic blood pressure ( 28739976 26390057 27618447 29403010 27618452 27841878 28135244) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Triglyceride levels ( 32203549 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Type 2 diabetes ( 30718926 21874001 22885922 28869590 24509480 32499647 30297969 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 25673412 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 20935629 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in inactive individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412)	Gestational age at birth (maternal effect) ( 28877031)
Interacting Genes		25 interacting genes: CDC5L CHFR DAPK3 EGFR ERBB2 FGFR1 FRS3 GIGYF1 GIGYF2 GOLGA2 HCK IGF1R INSR IRS1 MAP3K14 MET PDGFRA PDGFRB PRKCZ SQSTM1 STK26 TEK TNKS2 TRIM27 TRIM55	13 interacting genes: APP CEP76 CFTR GOLGA2 GRB14 IKZF3 MBP NEDD4 OGT RAF1 SRPK1 TRAF6 TRIM27
Entrez ID		2888	51765
HPRD ID		03313	06663
Ensembl ID		ENSG00000115290	ENSG00000134602
Uniprot IDs		Q14449	Q9P289
PDB IDs		2AUG 2AUH 4K81	3GGF 3W8I 4FZA 4FZD 4FZF 4GEH 5XY9 5YF4 7B36
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Activity Protein Tyrosine Kinase Activity Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Transferase Activity Signal Transduction Protein Autophosphorylation Receptor Complex Protein Phosphorylation Protein Modification Process Phosphorylation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Signaling Pathway ATP Binding Nucleotide Binding Identical Protein Binding Regulation Of Cellular Component Organization Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MAPK Cascade Insulin Receptor Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Migration Positive Regulation Of Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Insulin-like Growth Factor Receptor Signaling Pathway Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Cell Population Proliferation Regulation Of Organelle Organization Regulation Of Signal Transduction Regulation Of Cell Migration Insulin Receptor Substrate Binding Regulation Of Cell Motility Regulation Of Intracellular Signal Transduction Regulation Of Locomotion Phosphatidylinositol 3-kinase Binding Positive Regulation Of Cellular Component Organization Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Basal Plasma Membrane Regulation Of Programmed Cell Death Regulation Of ERK1 And ERK2 Cascade	Positive Regulation Of Protein Metabolic Process Protein-containing Complex Enzyme Binding Cytosol Protein K63-linked Ubiquitination Positive Regulation Of Macromolecule Metabolic Process Innate Immune Response Positive Regulation Of Interleukin-6 Production Regulation Of Protein Metabolic Process Response To Other Organism Protein Modification Process Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Immune Response Positive Regulation Of Metabolic Process Intracellular Signal Transduction Homeostatic Process Defense Response To Symbiont Defense Response To Other Organism Regulation Of Interleukin-6 Production Positive Regulation Of Biosynthetic Process Response To External Biotic Stimulus Cytoplasm Immune System Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse Defense Response Negative Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Proteolysis Amyloid-beta Complex Regulation Of Phosphorus Metabolic Process Growth Cone Lamellipodium Regulation Of Primary Metabolic Process Protein Metabolic Process Positive Regulation Of Cytokine Production Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Negative Regulation Of Transcription By RNA Polymerase II Response To Stress Amylin Binding Negative Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Developmental Process Intracellular Chemical Homeostasis Leukocyte Activation Negative Regulation Of Cell Communication Establishment Of Localization In Cell Regulation Of Cellular Localization Intracellularly ATP-gated Chloride Channel Activity
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