GRB14 and TNKS2

Number of citations of the paper that reports this interaction (PMID 11278563)
28

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		GRB14	TNKS2
Gene Name		growth factor receptor-bound protein 14	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytoplasm Cytosol Plasma Membrane Endosome Membrane Intracellular Membrane-bounded Organelle	Golgi Membrane Pericentriolar Material Nuclear Chromosome, Telomeric Region Nucleus Nuclear Envelope Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	SH3/SH2 Adaptor Activity	NAD+ ADP-ribosyltransferase Activity Protein Binding Enzyme Binding Metal Ion Binding
	Biological Process	Signal Transduction Blood Coagulation Positive Regulation Of Signal Transduction Leukocyte Migration	Protein Polyubiquitination Protein ADP-ribosylation Wnt Signaling Pathway Positive Regulation Of Telomere Maintenance Via Telomerase Multicellular Organism Growth Regulation Of Multicellular Organism Growth Protein Localization To Chromosome, Telomeric Region Protein Auto-ADP-ribosylation Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Tie2 Signaling Cell surface interactions at the vascular wall	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Blood pressure ( 21572416) Fasting insulin-related traits (interaction with BMI) ( 22581228) Response to statin therapy ( 20339536) Type 2 diabetes ( 21874001) Waist-hip ratio ( 20935629)
Protein-Protein Interactions		14 interactors: CDC5L DAPK3 EGFR FGFR1 IGF1R INSR IRS1 MAP3K14 PDGFRA PDGFRB PRKCZ SQSTM1 TEK TNKS2	8 interactors: GRB14 LNPEP MAPK1 SH3BP2 TERF1 TNKS TNKS1BP1 ZNF512B
Entrez ID		2888	80351
HPRD ID		03313	06182
Ensembl ID		ENSG00000115290	ENSG00000107854
Uniprot IDs		B7Z7F9 Q14449	Q9H2K2
PDB IDs		2AUG 2AUH 4K81	2Y0I 3KR7 3KR8 3MHJ 3MHK 3P0N 3P0P 3P0Q 3TWQ 3TWR 3TWS 3TWT 3TWU 3TWV 3TWW 3TWX 3U9H 3U9Y 3UA9 3W51 4AVU 4AVW 4BFP 4HKI 4HKK 4HKN 4HL5 4HLF 4HLG 4HLH 4HLK 4HLM 4HMH 4HYF 4IUE 4J1Z 4J21 4J22 4J3L 4J3M
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Intracellular Signal Transduction Protein Autophosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Positive Regulation Of Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorylation Positive Regulation Of Cell Motility Protein Phosphorylation Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of MAPK Cascade Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Peptidyl-tyrosine Phosphorylation Phosphatidylinositol-mediated Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation Positive Regulation Of DNA Metabolic Process Phosphorylation Positive Regulation Of Cellular Metabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Phospholipase Activity Positive Regulation Of DNA Replication Regulation Of Cell Migration Response To Growth Factor Regulation Of Phospholipase Activity Regulation Of Cell Motility Positive Regulation Of Lipase Activity Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Locomotion Regulation Of Cellular Component Movement Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Protein Phosphorylation Neurotrophin Signaling Pathway Signaling Cell Communication Cellular Protein Modification Process Cellular Response To Organonitrogen Compound Regulation Of Intracellular Signal Transduction Response To Organonitrogen Compound Response To Organic Substance	Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Peptidyl-threonine Phosphorylation Telomere Maintenance Positive Regulation Of Signal Transduction MAPK Import Into Nucleus Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Peptidyl-serine Phosphorylation Regulation Of DNA Replication Telomeric Loop Formation Age-dependent Telomere Shortening Protein Poly-ADP-ribosylation Positive Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomere Shortening Regulation Of Golgi Inheritance Protein Auto-ADP-ribosylation Protein Polyubiquitination Caveolin-mediated Endocytosis Cytosine Metabolic Process Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Chromosome Organization Regulation Of Golgi Organization Positive Regulation Of Telomere Maintenance Regulation Of Organelle Organization Cellular Macromolecule Biosynthetic Process Replicative Cell Aging Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Macromolecule Biosynthetic Process Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Telomerase Activity Negative Regulation Of Telomere Maintenance DNA Replication Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Microtubule Polymerization Mitotic Nuclear Division Regulation Of Telomerase Activity Positive Regulation Of Peptidyl-threonine Phosphorylation ERK1 And ERK2 Cascade
Tagcloud ?		adapter appears avidly bear bps conversely denote domain domains dramatically existence grb10 grb7 homology interact interaction interacts ir location loop obvious paired pleckstrin resemblance sh2 summary unidentified y1150f y1151f	abt actively adp azd bsi continues crystal detailed explored guide heightened indications inhibitors insight manifesting modes parp parp1 parp2 parp5a parp5b poly rational relevance ribose stranded tankyrase tnks1 valuable
Tagcloud (Difference) ?		adapter appears avidly bear bps conversely denote domain domains dramatically existence grb10 grb7 homology interact interaction interacts ir location loop obvious paired pleckstrin resemblance sh2 summary unidentified y1150f y1151f	abt actively adp azd bsi continues crystal detailed explored guide heightened indications inhibitors insight manifesting modes parp parp1 parp2 parp5a parp5b poly rational relevance ribose stranded tankyrase tnks1 valuable
Tagcloud (Intersection) ?