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DIABLO and BIRC3
Number of citations of the paper that reports this interaction (PubMedID
10929712
)
0
Data Source:
HPRD
(in vivo)
DIABLO
BIRC3
Description
diablo IAP-binding mitochondrial protein
baculoviral IAP repeat containing 3
Image
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Mitochondrial Intermembrane Space
Cytosol
Cytoplasmic Side Of Plasma Membrane
CD40 Receptor Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Protein-containing Complex
Molecular Function
Protein Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Protein-containing Complex Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Apoptotic Process
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Positive Regulation Of Apoptotic Process
Neuron Apoptotic Process
Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Apoptotic Process
Cell Surface Receptor Signaling Pathway
Canonical NF-kappaB Signal Transduction
Spermatogenesis
Positive Regulation Of Protein Ubiquitination
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Toll-like Receptor Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Regulation Of RIG-I Signaling Pathway
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Innate Immune Response
Regulation Of Inflammatory Response
Regulation Of Cell Cycle
Regulation Of Necroptotic Process
Negative Regulation Of Necroptotic Process
Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Pathways
Release of apoptotic factors from the mitochondria
SMAC (DIABLO) binds to IAPs
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
SMAC, XIAP-regulated apoptotic response
Regulation of the apoptosome activity
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIPK1-mediated regulated necrosis
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
TNFR2 non-canonical NF-kB pathway
Regulation of necroptotic cell death
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Ub-specific processing proteases
IKK complex recruitment mediated by RIP1
Drugs
Phenethyl Isothiocyanate
Diseases
GWAS
A body shape index (
34021172
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Prostate cancer (
23535732
)
Whole-brain volume (Alzheimer's disease interaction) (
21116278
)
Interacting Genes
45 interacting genes:
AGTRAP
APOC2
APOC4
AREL1
ARL6IP1
ARNT
BEX3
BIRC2
BIRC3
BIRC5
BIRC6
BIRC7
CASP9
CDC34
CMTM4
DERL2
DGAT2L6
DHRS1
E2F1
EEF1A1
FADS6
FKBP7
HSD17B13
HSFX1
HTRA2
LTBR
MAML2
MICOS13
MPC2
NR4A1
RHBDD2
RMDN2
SEC22A
SFT2D1
SLC17A9
SLC25A47
SLC66A2
STMN4
SYP
TIMMDC1
UBC
UBE2K
UFM1
XIAP
ZNF746
37 interacting genes:
BIRC5
CASP3
CASP7
CASP9
CD40
CTBP2
CYFIP2
DIABLO
DZIP3
GLMN
GSPT1
HAX1
HTRA2
IKBKE
MAP3K14
MBTPS1
PACS2
PELI1
RAF1
RCHY1
RIPK3
RIPK4
SNX7
SPHK1
SUMO1
TRAF1
TRAF2
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2I
UBE2N
UBE2Q2
UBE2V1
USP19
YOD1
Entrez ID
56616
330
HPRD ID
05560
03426
Ensembl ID
ENSG00000184047
ENSG00000023445
Uniprot IDs
A0A0S2Z5P6
A0A0S2Z5U7
K7X1S0
Q502X2
Q9NR28
Q13489
PDB IDs
1FEW
1G3F
1G73
1OXQ
1TW6
1XB0
1XB1
3D9U
3UIH
3UIJ
4TX5
6JX6
8ATO
8AUW
8E2I
8E2J
2UVL
3EB5
3EB6
3M0A
3M0D
7NK0
Enriched GO Terms of Interacting Partners
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Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Cell Death
Apoptotic Process
Programmed Cell Death
Ubiquitin-protein Transferase Activity
Cysteine-type Endopeptidase Inhibitor Activity
Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Positive Regulation Of Post-translational Protein Modification
Regulation Of Post-translational Protein Modification
Cellular Response To Interferon-beta
Macromolecule Catabolic Process
Negative Regulation Of Apoptotic Process
Protein Modification By Small Protein Conjugation
Ubiquitin Conjugating Enzyme Activity
Negative Regulation Of Programmed Cell Death
Response To Interferon-beta
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Protein Ubiquitination
Signal Recognition Particle Binding
Peptidase Inhibitor Activity
Post-translational Protein Modification
Ubiquitin Protein Ligase Activity
CD40 Receptor Complex
Proteolysis Involved In Protein Catabolic Process
Positive Regulation Of Protein Modification Process
Identical Protein Binding
Canonical NF-kappaB Signal Transduction
Organophosphate Ester Transport
Regulation Of Inflammatory Response
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Protein Polyubiquitination
Proteolysis
Positive Regulation Of Protein Polyubiquitination
Response To Hypoxia
Negative Regulation Of Necroptotic Process
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Protein Catabolic Process
Regulation Of RIG-I Signaling Pathway
Very-low-density Lipoprotein Particle
Negative Regulation Of Programmed Necrotic Cell Death
Response To Decreased Oxygen Levels
Protein Binding
Positive Regulation Of Execution Phase Of Apoptosis
Regulation Of Protein Modification Process
Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Regulation Of Canonical NF-kappaB Signal Transduction
Nucleotide Transmembrane Transport
Post-translational Protein Modification
Protein Modification Process
Ubiquitin Conjugating Enzyme Activity
Protein Metabolic Process
Protein Modification By Small Protein Conjugation
Macromolecule Catabolic Process
Ubiquitin-protein Transferase Activity
CD40 Receptor Complex
Protein Polyubiquitination
Proteolysis
Cytosol
Ubiquitin Protein Ligase Binding
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Canonical NF-kappaB Signal Transduction
Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Programmed Cell Death
Cell Death
Protein Ubiquitination
Positive Regulation Of Intracellular Signal Transduction
Intracellular Signal Transduction
Cellular Response To Stress
Positive Regulation Of Signal Transduction
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Positive Regulation Of Protein Ubiquitination
Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of DNA-binding Transcription Factor Activity
Catabolic Process
Transferase Activity
Regulation Of Intracellular Signal Transduction
Regulation Of Protein Metabolic Process
Positive Regulation Of Cell Communication
Regulation Of Primary Metabolic Process
Positive Regulation Of Signaling
Positive Regulation Of Post-translational Protein Modification
Apoptotic Signaling Pathway
Protein Catabolic Process
DNA Damage Response
Regulation Of Metabolic Process
Regulation Of Programmed Cell Death
Fibroblast Apoptotic Process
Macromolecule Metabolic Process
Proteolysis Involved In Protein Catabolic Process
Response To Stress
Intrinsic Apoptotic Signaling Pathway
Protein K48-linked Ubiquitination
Regulation Of Protein Ubiquitination
Neuron Apoptotic Process
Regulation Of Signal Transduction
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