DIABLO and RMDN2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DIABLO	RMDN2
Description		diablo IAP-binding mitochondrial protein	regulator of microtubule dynamics 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex	Spindle Pole Cytoplasm Mitochondrion Golgi Apparatus Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Membrane Mitotic Spindle Mitotic Spindle Pole
	Molecular Function	Protein Binding	Protein Binding Microtubule Binding
	Biological Process	Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Apoptotic Process Neuron Apoptotic Process Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway
Pathways		Release of apoptotic factors from the mitochondria SMAC (DIABLO) binds to IAPs SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC, XIAP-regulated apoptotic response Regulation of the apoptosome activity
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		A body shape index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Childhood asthma exacerbations in long-acting beta2-agonist treatment ( 33706416) Cutaneous malignant melanoma ( 26237428) Eosinophil count ( 32888494) Melanoma ( 28212542)
Interacting Genes		45 interacting genes: AGTRAP APOC2 APOC4 AREL1 ARL6IP1 ARNT BEX3 BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 CASP9 CDC34 CMTM4 DERL2 DGAT2L6 DHRS1 E2F1 EEF1A1 FADS6 FKBP7 HSD17B13 HSFX1 HTRA2 LTBR MAML2 MICOS13 MPC2 NR4A1 RHBDD2 RMDN2 SEC22A SFT2D1 SLC17A9 SLC25A47 SLC66A2 STMN4 SYP TIMMDC1 UBC UBE2K UFM1 XIAP ZNF746	14 interacting genes: AGTRAP CMTM5 DIABLO HSD17B11 LMNA RDH10 RTN3 SAR1A STX1A THAP4 TNFRSF10D VAPA VAPB VEZT
Entrez ID		56616	151393
HPRD ID		05560	08741
Ensembl ID		ENSG00000184047	ENSG00000115841
Uniprot IDs		A0A0S2Z5P6 A0A0S2Z5U7 K7X1S0 Q502X2 Q9NR28	A0A0C4DFM4 Q96LZ7
PDB IDs		1FEW 1G3F 1G73 1OXQ 1TW6 1XB0 1XB1 3D9U 3UIH 3UIJ 4TX5 6JX6 8ATO 8AUW 8E2I 8E2J
Enriched GO Terms of Interacting Partners?		Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Cell Death Apoptotic Process Programmed Cell Death Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Post-translational Protein Modification Regulation Of Post-translational Protein Modification Cellular Response To Interferon-beta Macromolecule Catabolic Process Negative Regulation Of Apoptotic Process Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Negative Regulation Of Programmed Cell Death Response To Interferon-beta Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Protein Ubiquitination Signal Recognition Particle Binding Peptidase Inhibitor Activity Post-translational Protein Modification Ubiquitin Protein Ligase Activity CD40 Receptor Complex Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Modification Process Identical Protein Binding Canonical NF-kappaB Signal Transduction Organophosphate Ester Transport Regulation Of Inflammatory Response Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Polyubiquitination Proteolysis Positive Regulation Of Protein Polyubiquitination Response To Hypoxia Negative Regulation Of Necroptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Catabolic Process Regulation Of RIG-I Signaling Pathway Very-low-density Lipoprotein Particle Negative Regulation Of Programmed Necrotic Cell Death Response To Decreased Oxygen Levels Protein Binding Positive Regulation Of Execution Phase Of Apoptosis Regulation Of Protein Modification Process Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Nucleotide Transmembrane Transport	FFAT Motif Binding Endoplasmic Reticulum Exit Site Membrane Organization COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Endoplasmic Reticulum Localization Endoplasmic Reticulum Organization Organelle Localization By Membrane Tethering Host-mediated Activation Of Viral Genome Replication Host-mediated Perturbation Of Viral Genome Replication Membrane Docking Host-mediated Suppression Of Viral Genome Replication Endoplasmic Reticulum Membrane Organization Endoplasmic Reticulum Vesicle Organization Endoplasmic Reticulum Membrane Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Myosin Binding Viral Release From Host Cell Vesicle Budding From Membrane Protein-membrane Adaptor Activity Organelle Localization Host-mediated Activation Of Viral Process Myosin Head/neck Binding Peroxynitrite Isomerase Activity Primary Lung Bud Formation Positive Regulation Of Retinoic Acid Biosynthetic Process Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Nuclear Membrane Cholesterol Transport Golgi Vesicle Transport DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Negative Regulation By Virus Of Viral Protein Levels In Host Cell Amino Acid Sensor Activity Vesicle-mediated Transport Host-mediated Perturbation Of Viral Process Intracellular Transport Sterol Transport Positive Regulation Of Norepinephrine Secretion Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Nitrate Metabolic Process Steroid Dehydrogenase Activity Lipid Droplet Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Angiotensin Type II Receptor Activity Regulation Of Isoprenoid Metabolic Process Host-mediated Perturbation Of Symbiont Process
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