DIABLO and MICOS13

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DIABLO	MICOS13
Description		diablo IAP-binding mitochondrial protein	mitochondrial contact site and cristae organizing system subunit 13
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex	SAM Complex Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Crista Junction MICOS Complex MIB Complex
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Apoptotic Process Neuron Apoptotic Process Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway	Inner Mitochondrial Membrane Organization Cristae Formation
Pathways		Release of apoptotic factors from the mitochondria SMAC (DIABLO) binds to IAPs SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC, XIAP-regulated apoptotic response Regulation of the apoptosome activity	Cristae formation
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		A body shape index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		45 interacting genes: AGTRAP APOC2 APOC4 AREL1 ARL6IP1 ARNT BEX3 BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 CASP9 CDC34 CMTM4 DERL2 DGAT2L6 DHRS1 E2F1 EEF1A1 FADS6 FKBP7 HSD17B13 HSFX1 HTRA2 LTBR MAML2 MICOS13 MPC2 NR4A1 RHBDD2 RMDN2 SEC22A SFT2D1 SLC17A9 SLC25A47 SLC66A2 STMN4 SYP TIMMDC1 UBC UBE2K UFM1 XIAP ZNF746	11 interacting genes: ACSF2 APOC1 APOC2 APOC4 DIABLO HSFX1 HSFX2 PBX3 RHBDD2 TEX44 UBC
Entrez ID		56616	125988
HPRD ID		05560	15198
Ensembl ID		ENSG00000184047	ENSG00000174917
Uniprot IDs		A0A0S2Z5P6 A0A0S2Z5U7 K7X1S0 Q502X2 Q9NR28	A0A140TA84 A0A140TA86 Q5XKP0
PDB IDs		1FEW 1G3F 1G73 1OXQ 1TW6 1XB0 1XB1 3D9U 3UIH 3UIJ 4TX5 6JX6 8ATO 8AUW 8E2I 8E2J
Enriched GO Terms of Interacting Partners?		Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Cell Death Apoptotic Process Programmed Cell Death Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Post-translational Protein Modification Regulation Of Post-translational Protein Modification Cellular Response To Interferon-beta Macromolecule Catabolic Process Negative Regulation Of Apoptotic Process Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Negative Regulation Of Programmed Cell Death Response To Interferon-beta Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Protein Ubiquitination Signal Recognition Particle Binding Peptidase Inhibitor Activity Post-translational Protein Modification Ubiquitin Protein Ligase Activity CD40 Receptor Complex Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Modification Process Identical Protein Binding Canonical NF-kappaB Signal Transduction Organophosphate Ester Transport Regulation Of Inflammatory Response Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Polyubiquitination Proteolysis Positive Regulation Of Protein Polyubiquitination Response To Hypoxia Negative Regulation Of Necroptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Catabolic Process Regulation Of RIG-I Signaling Pathway Very-low-density Lipoprotein Particle Negative Regulation Of Programmed Necrotic Cell Death Response To Decreased Oxygen Levels Protein Binding Positive Regulation Of Execution Phase Of Apoptosis Regulation Of Protein Modification Process Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Nucleotide Transmembrane Transport	High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Acylglycerol Homeostasis Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Triglyceride Homeostasis Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance Regulation Of Phospholipid Catabolic Process Lipase Inhibitor Activity Chylomicron Phospholipid Efflux Negative Regulation Of Lipoprotein Particle Clearance Negative Regulation Of Cholesterol Transport Plasma Lipoprotein Particle Clearance Lipid Homeostasis Cholesterol Efflux Negative Regulation Of Receptor-mediated Endocytosis Lipoprotein Metabolic Process Regulation Of Phospholipid Metabolic Process Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Negative Regulation Of Lipid Transport Regulation Of Triglyceride Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Phosphatidylcholine Catabolic Process Posterior Compartment Specification Anterior Compartment Pattern Formation Regulation Of Lipid Catabolic Process Regulation Of Cholesterol Transport Cholesterol Transport Negative Regulation Of Endocytosis Lipid Transport Sterol Transport Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Phospholipid Transport Regulation Of Fatty Acid Metabolic Process Regulation Of Phosphatidylcholine Catabolic Process Positive Regulation Of Phospholipid Catabolic Process Lipoprotein Lipase Activator Activity Negative Regulation Of Lipid Metabolic Process Chylomicron Remodeling Compartment Pattern Specification Regulation Of Receptor-mediated Endocytosis Very-low-density Lipoprotein Particle Clearance Regulation Of Ketone Metabolic Process Intermediate-density Lipoprotein Particle Dorsal Spinal Cord Development Sequence-specific DNA Binding Phosphatidylcholine-sterol O-acyltransferase Activator Activity Organophosphate Ester Transport
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