DIABLO and SLC66A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DIABLO	SLC66A2
Description		diablo IAP-binding mitochondrial protein	solute carrier family 66 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex	Endosome Trans-Golgi Network Cytosol Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Apoptotic Process Neuron Apoptotic Process Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway	Retrograde Transport, Endosome To Golgi Phospholipid Translocation
Pathways		Release of apoptotic factors from the mitochondria SMAC (DIABLO) binds to IAPs SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC, XIAP-regulated apoptotic response Regulation of the apoptosome activity
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		A body shape index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		45 interacting genes: AGTRAP APOC2 APOC4 AREL1 ARL6IP1 ARNT BEX3 BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 CASP9 CDC34 CMTM4 DERL2 DGAT2L6 DHRS1 E2F1 EEF1A1 FADS6 FKBP7 HSD17B13 HSFX1 HTRA2 LTBR MAML2 MICOS13 MPC2 NR4A1 RHBDD2 RMDN2 SEC22A SFT2D1 SLC17A9 SLC25A47 SLC66A2 STMN4 SYP TIMMDC1 UBC UBE2K UFM1 XIAP ZNF746	24 interacting genes: ADH5 AQP6 BEST2 CD79A CLCN7 DIABLO FBLN1 FUNDC2 GJA8 GPR152 IL10RA KCNK5 MGLL RHBDD1 SLC10A1 SLC10A6 SLC25A46 SLC35E3 SLC71A2 STX12 TMEM31 TMEM44 TMEM80 ZFYVE27
Entrez ID		56616	80148
HPRD ID		05560	11454
Ensembl ID		ENSG00000184047	ENSG00000122490
Uniprot IDs		A0A0S2Z5P6 A0A0S2Z5U7 K7X1S0 Q502X2 Q9NR28	K7ERV4 Q8N2U9
PDB IDs		1FEW 1G3F 1G73 1OXQ 1TW6 1XB0 1XB1 3D9U 3UIH 3UIJ 4TX5 6JX6 8ATO 8AUW 8E2I 8E2J
Enriched GO Terms of Interacting Partners?		Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Cell Death Apoptotic Process Programmed Cell Death Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Post-translational Protein Modification Regulation Of Post-translational Protein Modification Cellular Response To Interferon-beta Macromolecule Catabolic Process Negative Regulation Of Apoptotic Process Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Negative Regulation Of Programmed Cell Death Response To Interferon-beta Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Protein Ubiquitination Signal Recognition Particle Binding Peptidase Inhibitor Activity Post-translational Protein Modification Ubiquitin Protein Ligase Activity CD40 Receptor Complex Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Modification Process Identical Protein Binding Canonical NF-kappaB Signal Transduction Organophosphate Ester Transport Regulation Of Inflammatory Response Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Polyubiquitination Proteolysis Positive Regulation Of Protein Polyubiquitination Response To Hypoxia Negative Regulation Of Necroptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Catabolic Process Regulation Of RIG-I Signaling Pathway Very-low-density Lipoprotein Particle Negative Regulation Of Programmed Necrotic Cell Death Response To Decreased Oxygen Levels Protein Binding Positive Regulation Of Execution Phase Of Apoptosis Regulation Of Protein Modification Process Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Nucleotide Transmembrane Transport	Transmembrane Transport Membrane Bile Acid:sodium Symporter Activity Chloride Transmembrane Transport Chloride Transport Bile Acid And Bile Salt Transport Inorganic Anion Transmembrane Transport S-(hydroxymethyl)glutathione Dehydrogenase (NADP+) Activity Formaldehyde Dehydrogenase (NAD+) Activity S-(hydroxymethyl)glutathione Dehydrogenase (NAD+) Activity Nitrate Transmembrane Transporter Activity Monoatomic Anion Transmembrane Transport Inorganic Anion Transport Channel Activity Monoatomic Anion Transport Monoatomic Ion Transport Interleukin-10 Binding Organic Hydroxy Compound Transport Intracellularly Ligand-gated Monoatomic Ion Channel Activity Nucleotide-sugar Transmembrane Transporter Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport
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