DIABLO and SYP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DIABLO	SYP
Description		diablo IAP-binding mitochondrial protein	synaptophysin
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex	Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuromuscular Junction Presynaptic Membrane Neuron Projection Terminal Bouton Neuron Projection Terminus Synapse Perinuclear Region Of Cytoplasm Presynaptic Active Zone Excitatory Synapse Schaffer Collateral - CA1 Synapse Presynapse
	Molecular Function	Protein Binding	Protein Binding Cholesterol Binding SH2 Domain Binding Identical Protein Binding
	Biological Process	Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Apoptotic Process Neuron Apoptotic Process Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway	Endocytosis Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Maturation Regulation Of Neuronal Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Short-term Neuronal Synaptic Plasticity Synaptic Vesicle Membrane Organization Modulation Of Chemical Synaptic Transmission Regulation Of Opioid Receptor Signaling Pathway
Pathways		Release of apoptotic factors from the mitochondria SMAC (DIABLO) binds to IAPs SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC, XIAP-regulated apoptotic response Regulation of the apoptosome activity	Sensory processing of sound by inner hair cells of the cochlea
Drugs		Phenethyl Isothiocyanate
Diseases			Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		A body shape index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		45 interacting genes: AGTRAP APOC2 APOC4 AREL1 ARL6IP1 ARNT BEX3 BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 CASP9 CDC34 CMTM4 DERL2 DGAT2L6 DHRS1 E2F1 EEF1A1 FADS6 FKBP7 HSD17B13 HSFX1 HTRA2 LTBR MAML2 MICOS13 MPC2 NR4A1 RHBDD2 RMDN2 SEC22A SFT2D1 SLC17A9 SLC25A47 SLC66A2 STMN4 SYP TIMMDC1 UBC UBE2K UFM1 XIAP ZNF746	41 interacting genes: AP1G1 ARFIP2 CAND2 CD160 DIABLO FARS2 GAB1 GDNF GRB2 HSFX1 HSFX2 JOSD2 LNPK MIEF1 MIEF2 MRM1 MRRF MTERF3 MYG1 NDRG4 PBX3 PITPNC1 PLIN3 PNKP PPIF PTCD1 PTPN9 RBFA SH3GLB1 SIAH1 SIAH2 SMG9 SNX1 SPG21 SSX5 STARD4 THAP4 TUFM VAMP2 WDFY2 WIPI2
Entrez ID		56616	6855
HPRD ID		05560	02435
Ensembl ID		ENSG00000184047	ENSG00000102003
Uniprot IDs		A0A0S2Z5P6 A0A0S2Z5U7 K7X1S0 Q502X2 Q9NR28	P08247
PDB IDs		1FEW 1G3F 1G73 1OXQ 1TW6 1XB0 1XB1 3D9U 3UIH 3UIJ 4TX5 6JX6 8ATO 8AUW 8E2I 8E2J
Enriched GO Terms of Interacting Partners?		Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Cell Death Apoptotic Process Programmed Cell Death Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Post-translational Protein Modification Regulation Of Post-translational Protein Modification Cellular Response To Interferon-beta Macromolecule Catabolic Process Negative Regulation Of Apoptotic Process Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Negative Regulation Of Programmed Cell Death Response To Interferon-beta Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Protein Ubiquitination Signal Recognition Particle Binding Peptidase Inhibitor Activity Post-translational Protein Modification Ubiquitin Protein Ligase Activity CD40 Receptor Complex Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Modification Process Identical Protein Binding Canonical NF-kappaB Signal Transduction Organophosphate Ester Transport Regulation Of Inflammatory Response Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Polyubiquitination Proteolysis Positive Regulation Of Protein Polyubiquitination Response To Hypoxia Negative Regulation Of Necroptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Catabolic Process Regulation Of RIG-I Signaling Pathway Very-low-density Lipoprotein Particle Negative Regulation Of Programmed Necrotic Cell Death Response To Decreased Oxygen Levels Protein Binding Positive Regulation Of Execution Phase Of Apoptosis Regulation Of Protein Modification Process Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Nucleotide Transmembrane Transport	Positive Regulation Of Natural Killer Cell Degranulation Dorsal Spinal Cord Development Mitochondrion Mitochondrial Matrix Mitochondrial Outer Membrane
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