BIN1 and FHL2

Number of citations of the paper that reports this interaction (PubMedID 10906324)
0

Data Source:
BioGRID (two hybrid)

		BIN1	FHL2
Description		bridging integrator 1	four and a half LIM domains 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Synaptic Vesicle Actin Cytoskeleton Membrane Z Disc T-tubule Axon Dendrite I Band Vesicle Node Of Ranvier Axon Initial Segment Varicosity Axon Terminus Cerebellar Mossy Fiber Lipid Tube RNA Polymerase II Transcription Repressor Complex Extrinsic Component Of Synaptic Vesicle Membrane Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Focal Adhesion Z Disc
	Molecular Function	Protease Binding Protein Binding Phospholipid Binding Lipid Binding Aspartic-type Endopeptidase Inhibitor Activity Clathrin Binding Identical Protein Binding Protein-containing Complex Binding Tau Protein Binding Actin Filament Binding GTPase Binding Protein-folding Chaperone Binding RNA Polymerase Binding	Transcription Corepressor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Identical Protein Binding BHLH Transcription Factor Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endocytosis Nucleus Organization Cytoskeleton Organization Endosome To Lysosome Transport Regulation Of Cell Cycle Process Regulation Of Endocytosis Cell Differentiation Positive Regulation Of Actin Filament Polymerization T-tubule Organization Positive Regulation Of Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Astrocyte Differentiation Establishment Of Localization In Cell Lipid Tube Assembly Regulation Of Heart Rate By Cardiac Conduction Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Regulation Of Transcription By RNA Polymerase II Response To Hormone Negative Regulation Of Apoptotic Process Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Heart Trabecula Formation Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Pathways		Clathrin-mediated endocytosis	PPARA activates gene expression
Drugs
Diseases		Centronuclear myopathy
GWAS		Alzheimer's disease ( 21460840 31473137 21627779 22832961) Alzheimer's disease (late onset) ( 28714976 30617256 21390209 21460841 24162737) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 33589840 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Creatine kinase levels ( 29403010) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Family history of Alzheimer's disease ( 30617256) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Neuritic plaques or neurofibrillary tangles (pleiotropy) ( 29458411) Neurofibrillary tangles ( 25188341) Neutrophil count ( 32888494) Pelvic organ prolapse (moderate/severe) ( 26545240) Psychosis and Alzheimer's disease ( 22005930) Systemic lupus erythematosus ( 24871463)	Appendicular lean mass ( 33097823) Bipolar disorder x sex interaction ( 34099189) Body fat mass ( 28552196) Hip circumference adjusted for BMI ( 34021172) Household income (MTAG) ( 31844048) Lung cancer in ever smokers ( 28604730) PR interval ( 32439900) Pulse pressure ( 30224653 30578418) Walking pace ( 33128006)
Interacting Genes		48 interacting genes: ABL1 ACTA1 ACTG1 AMPH AP2A1 AP2A2 APP APPL1 ASAP2 ATXN2 CLIP1 CUX1 DLGAP4 DNM1 DNM2 E2F1 FBP1 FHL2 HUNK ITCH ITGA1 ITGA3 ITGA6 MAP4K3 MBNL1 MYC PDK1 PLD1 PLD2 PTGER4 PTK2 RAP1A RFX3 RIN2 RIN3 SH3GL2 SH3GLB1 SNAPIN SNX4 SOS1 SOS2 SYN1 SYNJ1 TP73 UBC WASL XRCC4 ZBTB3	175 interacting genes: A1CF ABI1 ABLIM1 ADAM17 AK1 AKIP1 AMOT ANKRD55 APP AR ARHGAP9 ATOSB ATXN1 BANP BARX2 BIN1 BLZF1 BMPR2 BRCA1 CACNA1C CAND2 CAPN1 CARD8 CATSPERT CCDC198 CCDC92 CDC73 CFTR CIMIP1 CKM CREBBP CSK CSN2 CTNNB1 DAPL1 DCP1A DDIT4L DLGAP1 DPF2 DRC4 DTX2 DUSP10 E2F1 E2F2 E2F3 E2F4 EP300 ESR1 FAM204A FHL1 FHL3 FHL5 FOXO1 GATAD2B GLYR1 GMEB2 GNG12 GNG4 GOLGA6A GTF2F2 GTF2H1 HAND1 HCK HSF2BP HSPB2 ID3 IDH1 IER3 IFI35 IGFBP5 IKZF1 IKZF4 IL16 INCA1 ITGA3 ITGA7 ITGB1 ITGB2 ITGB5 ITGB6 JUP KANK2 KIAA1217 KIF5B KLF12 KLHL20 KPRP LDLRAP1 LRIF1 MAGEL2 MBD3L1 MCM7 MDM2 MISP MYBPC1 MYO15B NBPF6 NIBAN1 NRF1 PFKM PHB2 PHF1 PHF21A PKNOX1 PKNOX2 POGZ POU6F2 PRDM11 PRDM6 PRR5L PSEN2 PUF60 QRICH1 RAI2 REL REV1 RFX3 RIPPLY1 RUNX2 SAP30BP SAXO1 SAXO2 SAXO4 SCNM1 SFPQ SH3RF1 SIGLEC6 SLAIN1 SLC34A1 SMAD2 SMAD3 SMAD4 SNAI1 SOX30 SP2 SPRY4 SREBF2 SRF STAT3 SUMO1P1 TCP10L TNFRSF11A TOX3 TRAF6 TRIM55 TRIM63 TRIM73 TTN TXNRD3 VXN WASHC1 WT1 YPEL3 YY1 ZBTB16 ZBTB25 ZFP64 ZFYVE9 ZMYM4 ZNF131 ZNF143 ZNF200 ZNF212 ZNF23 ZNF3 ZNF331 ZNF408 ZNF410 ZNF417 ZNF620 ZNF626 ZNF638 ZNF655 ZNF85 ZSCAN9
Entrez ID		274	2274
HPRD ID		03150	04026
Ensembl ID		ENSG00000136717	ENSG00000115641
Uniprot IDs		B7Z2Z2 B7Z6Y2 O00499 Q9BTH3	Q14192 Q2XQU9 Q6I9R8
PDB IDs		1MUZ 1MV0 1MV3 2FIC 2RMY 2RND 5I22	1X4K 1X4L 2D8Z 2MIU
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Regulation Of Vesicle-mediated Transport Endocytosis Vesicle-mediated Transport In Synapse Vesicle-mediated Transport Cytoplasmic Vesicle Import Into Cell Regulation Of Endocytosis Presynapse Synaptic Vesicle Endocytosis Regulation Of Plasma Membrane Organization Presynaptic Endocytosis Positive Regulation Of Cellular Component Organization Protein Kinase Binding Regulation Of Transport Regulation Of Receptor-mediated Endocytosis Receptor Internalization Clathrin-coated Pit Endocytic Vesicle Membrane Plasma Membrane Perinuclear Region Of Cytoplasm Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of Hematopoietic Progenitor Cell Differentiation Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Vesicle Scission Negative Regulation Of Membrane Tubulation Integrin-mediated Signaling Pathway Cytosol Small GTPase-mediated Signal Transduction Receptor-mediated Endocytosis Regulation Of Plasma Membrane Bounded Cell Projection Organization Establishment Of Localization In Cell Regulation Of Cell Projection Organization Regulation Of Vesicle Size Fc Receptor Signaling Pathway Glutamatergic Synapse Vesicle Localization Growth Cone Filopodium Cytoplasm Response To Growth Factor Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Early Endosome Cell Projection Organization Regulation Of Leukocyte Migration Fc Receptor Mediated Stimulatory Signaling Pathway Endocytic Vesicle Positive Regulation Of Cell Projection Organization Regulation Of Receptor Internalization	Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Negative Regulation Of DNA-templated Transcription Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Zinc Ion Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Positive Regulation Of Metabolic Process Transcription Regulator Complex Metal Ion Binding Regulation Of MiRNA Transcription Sequence-specific Double-stranded DNA Binding Chromatin Regulation Of MiRNA Metabolic Process Nucleoplasm DNA-templated Transcription Formation Of Primary Germ Layer Integrin Complex Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex
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