BIN1 and ZBTB3

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		BIN1	ZBTB3
Gene Name		bridging integrator 1	zinc finger and BTB domain containing 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Synaptic Vesicle Actin Cytoskeleton Membrane Z Disc T-tubule Axon I Band Node Of Ranvier Axon Initial Segment Varicosity Axon Terminus Cerebellar Mossy Fiber Lipid Tube	Nucleus
	Molecular Function	Protein Binding Protein Complex Binding Identical Protein Binding Protein Heterodimerization Activity Tau Protein Binding GTPase Binding RNA Polymerase Binding	DNA Binding Metal Ion Binding
	Biological Process	Endocytosis Cell Proliferation Viral Process Muscle Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis Positive Regulation Of Astrocyte Differentiation Lipid Tube Assembly Regulation Of Cell Cycle Arrest	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease ( 22832961 21460840 21627779 22005930) Alzheimer's disease (late onset) ( 21460841 21390209)
Protein-Protein Interactions		36 interactors: ABL1 AMPH AP2A1 AP2A2 APP ASAP2 ATXN2 CUX1 DLGAP4 DNM1 DNM2 FBP1 ITGA1 ITGA3 ITGA6 MAP4K3 MBNL1 MYC PLD1 PLD2 PTK2 RAP1A RFX3 RIN2 RIN3 SH3GL2 SH3GLB1 SNX4 SOS1 SOS2 SYN1 SYNJ1 TP73 UBC XRCC4 ZBTB3	21 interactors: ANKRD2 BIN1 EIF5B FOXM1 GATA4 GTF2A1L IKBKG IRF6 JADE2 LEF1 NR3C1 PKNOX1 PPARG PROX1 SKIL SMAD3 SSX3 SUPT5H THRA ZMYM2 ZNF556
Entrez ID		274	79842
HPRD ID		03150	15693
Ensembl ID		ENSG00000136717	ENSG00000185670
Uniprot IDs		B7Z6Y2 O00499 Q9BTH3	Q9H5J0
PDB IDs		1MUZ 1MV0 1MV3 2FIC 2RMY 2RND
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Endocytosis Generation Of Neurons Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Projection Organization Regulation Of ERBB Signaling Pathway Neurogenesis Neuron Projection Morphogenesis Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Signal Transduction Axon Guidance Neuron Differentiation Neuron Development Nervous System Development Vesicle-mediated Transport Chemotaxis Signaling Neuron Projection Development Locomotion Cell Communication Anatomical Structure Morphogenesis Cell Morphogenesis Axonogenesis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Axon Development Negative Regulation Of Signaling Cell Differentiation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of ERBB Signaling Pathway Regulation Of Cellular Process Cell Development Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin Signaling Pathway System Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Cell Morphogenesis Involved In Differentiation Regulation Of Catalytic Activity Regulation Of Intracellular Signal Transduction Movement Of Cell Or Subcellular Component Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Positive Regulation Of Apoptotic Process Blood Coagulation	Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Epithelial Cell Differentiation DNA-templated Transcription, Initiation Nitrogen Compound Metabolic Process Epithelium Development Gland Development Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Differentiation Regulation Of Cellular Process Tissue Development Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Organ Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Steroid Hormone Mediated Signaling Pathway Lens Fiber Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Cell Development Muscle Structure Development Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		a2m algorithm allele alzheimer amplicons apoe apoj biochip clut combinations cr1 determina e3 e4 epsilon2 epsilon4 exoc3l2 gab2 genotyping immobilized microchip oligonucleotides picalm predis rs11136000 sporadic studying tion tomm40
Tagcloud (Difference) ?		a2m algorithm allele alzheimer amplicons apoe apoj biochip clut combinations cr1 determina e3 e4 epsilon2 epsilon4 exoc3l2 gab2 genotyping immobilized microchip oligonucleotides picalm predis rs11136000 sporadic studying tion tomm40
Tagcloud (Intersection) ?