BIN1 and SYN1

Number of citations: 0 (PubMedID 10899172)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vitro, in vivo)

		BIN1	SYN1
Name		bridging integrator 1	synapsin I
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Synaptic Vesicle Actin Cytoskeleton Membrane Z Disc T-tubule Axon Dendrite I Band Vesicle Node Of Ranvier Axon Initial Segment Varicosity Axon Terminus Cerebellar Mossy Fiber Lipid Tube RNA Polymerase II Transcription Repressor Complex Extrinsic Component Of Synaptic Vesicle Membrane Glutamatergic Synapse	Synaptonemal Complex Golgi Apparatus Cytoskeleton Synaptic Vesicle Postsynaptic Density Axon Dendrite Synaptic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Cell Body Synapse Presynaptic Active Zone Schaffer Collateral - CA1 Synapse Presynapse Extrinsic Component Of Synaptic Vesicle Membrane
	Molecular Function	Protease Binding Protein Binding Phospholipid Binding Lipid Binding Aspartic-type Endopeptidase Inhibitor Activity Clathrin Binding Identical Protein Binding Protein-containing Complex Binding Tau Protein Binding Actin Filament Binding GTPase Binding Protein-folding Chaperone Binding RNA Polymerase Binding	Actin Binding Protein Binding ATP Binding Protein Kinase Binding Identical Protein Binding Calcium-dependent Protein Binding Cytoskeletal Protein-membrane Anchor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endocytosis Nucleus Organization Cytoskeleton Organization Endosome To Lysosome Transport Regulation Of Cell Cycle Process Regulation Of Endocytosis Cell Differentiation Positive Regulation Of Actin Filament Polymerization T-tubule Organization Positive Regulation Of Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Astrocyte Differentiation Establishment Of Localization In Cell Lipid Tube Assembly Regulation Of Heart Rate By Cardiac Conduction Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel	Chemical Synaptic Transmission Neurotransmitter Secretion Regulation Of Neurotransmitter Secretion Neuron Development Modulation Of Chemical Synaptic Transmission Synapse Organization Synaptic Vesicle Clustering Regulation Of Synaptic Vesicle Cycle Synaptic Vesicle Cycle Regulation Of Synaptic Vesicle Exocytosis
Pathways		Clathrin-mediated endocytosis	Serotonin Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Sensory processing of sound by inner hair cells of the cochlea
Drugs		None	Adenosine 5'-[gamma-thio]triphosphate
Diseases		Centronuclear myopathy	Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Alzheimer's disease ( 21460840 31473137 21627779 22832961 ) Alzheimer's disease (late onset) ( 28714976 30617256 21390209 21460841 24162737 ) Alzheimer's disease (onset between ages 58 and 79) ( 30979435 ) Alzheimer's disease in APOE e4+ carriers ( 25778476 ) Alzheimer's disease in APOE e4- carriers ( 25778476 ) Alzheimer's disease or family history of Alzheimer's disease ( 33589840 30617256 ) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717 ) Appendicular lean mass ( 33097823 ) Blood protein levels ( 30072576 ) Creatine kinase levels ( 29403010 ) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341 ) Family history of Alzheimer's disease ( 30617256 ) Metabolite levels ( 23823483 ) Monocyte percentage of white cells ( 32888494 ) Neuritic plaques or neurofibrillary tangles (pleiotropy) ( 29458411 ) Neurofibrillary tangles ( 25188341 ) Neutrophil count ( 32888494 ) Pelvic organ prolapse (moderate/severe) ( 26545240 ) Psychosis and Alzheimer's disease ( 22005930 ) Systemic lupus erythematosus ( 24871463 )	No GWAS studies recorded
Interacting Genes		48 interacting genes: ABL1 ACTA1 ACTG1 AMPH AP2A1 AP2A2 APP APPL1 ASAP2 ATXN2 CLIP1 CUX1 DLGAP4 DNM1 DNM2 E2F1 FBP1 FHL2 HUNK ITCH ITGA1 ITGA3 ITGA6 MAP4K3 MBNL1 MYC PDK1 PLD1 PLD2 PTGER4 PTK2 RAP1A RFX3 RIN2 RIN3 SH3GL2 SH3GLB1 SNAPIN SNX4 SOS1 SOS2 SYN1 SYNJ1 TP73 UBC WASL XRCC4 ZBTB3	30 interacting genes: AMPH BIN1 BLM CAMK1 CAMK2G CDK5 CRK ERG GRB2 ITSN2 KAT5 MAPK3 NOS1 NOS1AP PAK1 PAK2 PAK3 PFN2 PIK3R1 PLCG1 PRKACA RASA1 RB1CC1 S100A1 SNCA SPTAN1 SRC SYN2 SYN3 VIM
Entrez ID		274	6853
HPRD ID		03150	02433
Ensembl ID		ENSG00000136717	ENSG00000008056
Uniprot IDs		B7Z2Z2 B7Z6Y2 O00499 Q9BTH3	P17600
PDB IDs		1MUZ 1MV0 1MV3 2FIC 2RMY 2RND 5I22	Not available
GO Terms Enriched among Interactors		Regulation Of Cellular Component Organization Regulation Of Vesicle-mediated Transport Endocytosis Vesicle-mediated Transport In Synapse Vesicle-mediated Transport Cytoplasmic Vesicle Import Into Cell Regulation Of Endocytosis Presynapse Synaptic Vesicle Endocytosis Regulation Of Plasma Membrane Organization Presynaptic Endocytosis Positive Regulation Of Cellular Component Organization Protein Kinase Binding Regulation Of Transport Regulation Of Receptor-mediated Endocytosis Receptor Internalization Clathrin-coated Pit Endocytic Vesicle Membrane Plasma Membrane Perinuclear Region Of Cytoplasm Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of Hematopoietic Progenitor Cell Differentiation Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Vesicle Scission Negative Regulation Of Membrane Tubulation Integrin-mediated Signaling Pathway Cytosol Small GTPase-mediated Signal Transduction Receptor-mediated Endocytosis Regulation Of Plasma Membrane Bounded Cell Projection Organization Establishment Of Localization In Cell Regulation Of Cell Projection Organization Regulation Of Vesicle Size Fc Receptor Signaling Pathway Glutamatergic Synapse Vesicle Localization Growth Cone Filopodium Cytoplasm Response To Growth Factor Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Early Endosome Cell Projection Organization Regulation Of Leukocyte Migration Fc Receptor Mediated Stimulatory Signaling Pathway Endocytic Vesicle Positive Regulation Of Cell Projection Organization Regulation Of Receptor Internalization	Cytosol Regulation Of Cytoskeleton Organization Regulation Of Cellular Component Organization Vesicle-mediated Transport In Synapse Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Biological Quality Regulation Of Organelle Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Synaptic Vesicle Endocytosis Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Postsynaptic Density Regulation Of Cellular Localization Presynaptic Endocytosis Phosphotyrosine Residue Binding Ephrin Receptor Signaling Pathway Cytoplasm Regulation Of Protein-containing Complex Assembly Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Actin Filament Polymerization Regulation Of Defense Response Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Calcium Ion Transport Neurotrophin TRKA Receptor Binding Protein Serine Kinase Activity Protein Kinase Activity Actin Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Calcium Ion Transmembrane Transport Regulation Of Cellular Component Size Cellular Response To Nutrient Levels Protein Serine/threonine Kinase Activity Glutamatergic Synapse Actin Filament-based Process Cytoskeleton Organization Regulation Of Developmental Process Regulation Of Neuron Projection Development Kinase Activity Regulation Of Innate Immune Response Regulation Of Transport Cell Junction Organization Response To Growth Factor Regulation Of Heart Contraction Positive Regulation Of Protein-containing Complex Assembly