BIN1 and AP2A2

Number of citations: 44 (PubMedID 10430869)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vitro)

		BIN1	AP2A2
Name		bridging integrator 1	adaptor related protein complex 2 subunit alpha 2
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Synaptic Vesicle Actin Cytoskeleton Membrane Z Disc T-tubule Axon Dendrite I Band Vesicle Node Of Ranvier Axon Initial Segment Varicosity Axon Terminus Cerebellar Mossy Fiber Lipid Tube RNA Polymerase II Transcription Repressor Complex Extrinsic Component Of Synaptic Vesicle Membrane Glutamatergic Synapse	Cytosol Plasma Membrane Clathrin-coated Pit Cytoplasmic Side Of Plasma Membrane Membrane Membrane Coat AP-2 Adaptor Complex Clathrin Adaptor Complex Endocytic Vesicle Membrane Secretory Granule Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Clathrin-coated Endocytic Vesicle Presynapse Postsynapse Ficolin-1-rich Granule Membrane
	Molecular Function	Protease Binding Protein Binding Phospholipid Binding Lipid Binding Aspartic-type Endopeptidase Inhibitor Activity Clathrin Binding Identical Protein Binding Protein-containing Complex Binding Tau Protein Binding Actin Filament Binding GTPase Binding Protein-folding Chaperone Binding RNA Polymerase Binding	Protein Binding Lipid Binding Kinase Binding Protein Kinase Binding Protein Domain Specific Binding Clathrin Adaptor Activity Disordered Domain Specific Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endocytosis Nucleus Organization Cytoskeleton Organization Endosome To Lysosome Transport Regulation Of Cell Cycle Process Regulation Of Endocytosis Cell Differentiation Positive Regulation Of Actin Filament Polymerization T-tubule Organization Positive Regulation Of Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Astrocyte Differentiation Establishment Of Localization In Cell Lipid Tube Assembly Regulation Of Heart Rate By Cardiac Conduction Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel	Intracellular Protein Transport Endocytosis Protein Transport Vesicle-mediated Transport Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization
Pathways		Clathrin-mediated endocytosis	Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Neutrophil degranulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Diseases		Centronuclear myopathy	None
GWAS		Alzheimer's disease ( 21460840 31473137 21627779 22832961 ) Alzheimer's disease (late onset) ( 28714976 30617256 21390209 21460841 24162737 ) Alzheimer's disease (onset between ages 58 and 79) ( 30979435 ) Alzheimer's disease in APOE e4+ carriers ( 25778476 ) Alzheimer's disease in APOE e4- carriers ( 25778476 ) Alzheimer's disease or family history of Alzheimer's disease ( 33589840 30617256 ) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717 ) Appendicular lean mass ( 33097823 ) Blood protein levels ( 30072576 ) Creatine kinase levels ( 29403010 ) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341 ) Family history of Alzheimer's disease ( 30617256 ) Metabolite levels ( 23823483 ) Monocyte percentage of white cells ( 32888494 ) Neuritic plaques or neurofibrillary tangles (pleiotropy) ( 29458411 ) Neurofibrillary tangles ( 25188341 ) Neutrophil count ( 32888494 ) Pelvic organ prolapse (moderate/severe) ( 26545240 ) Psychosis and Alzheimer's disease ( 22005930 ) Systemic lupus erythematosus ( 24871463 )	Adult asthma ( 27611488 ) Alzheimer's disease ( 30636644 ) Alzheimer's disease (late onset) ( 24162737 ) Asthma ( 31959851 ) Chronic bronchitis and chronic obstructive pulmonary disease ( 25241909 ) Nicotine withdrawal ( 29532581 ) Nicotine withdrawal symptom count ( 29532581 )
Interacting Genes		48 interacting genes: ABL1 ACTA1 ACTG1 AMPH AP2A1 AP2A2 APP APPL1 ASAP2 ATXN2 CLIP1 CUX1 DLGAP4 DNM1 DNM2 E2F1 FBP1 FHL2 HUNK ITCH ITGA1 ITGA3 ITGA6 MAP4K3 MBNL1 MYC PDK1 PLD1 PLD2 PTGER4 PTK2 RAP1A RFX3 RIN2 RIN3 SH3GL2 SH3GLB1 SNAPIN SNX4 SOS1 SOS2 SYN1 SYNJ1 TP73 UBC WASL XRCC4 ZBTB3	18 interacting genes: AMPH ANXA1 AP1S1 AP2B1 APP BIN1 DNAJC6 DNM1 EPN1 EPS15 HTT NLGN3 NUMB SHC1 SLC2A8 SMAD1 SNAP91 UBC
Entrez ID		274	161
HPRD ID		03150	06256
Ensembl ID		ENSG00000136717	ENSG00000183020
Uniprot IDs		B7Z2Z2 B7Z6Y2 O00499 Q9BTH3	O94973
PDB IDs		1MUZ 1MV0 1MV3 2FIC 2RMY 2RND 5I22	Not available
GO Terms Enriched among Interactors		Regulation Of Cellular Component Organization Regulation Of Vesicle-mediated Transport Endocytosis Vesicle-mediated Transport In Synapse Vesicle-mediated Transport Cytoplasmic Vesicle Import Into Cell Regulation Of Endocytosis Presynapse Synaptic Vesicle Endocytosis Regulation Of Plasma Membrane Organization Presynaptic Endocytosis Positive Regulation Of Cellular Component Organization Protein Kinase Binding Regulation Of Transport Regulation Of Receptor-mediated Endocytosis Receptor Internalization Clathrin-coated Pit Endocytic Vesicle Membrane Plasma Membrane Perinuclear Region Of Cytoplasm Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of Hematopoietic Progenitor Cell Differentiation Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Vesicle Scission Negative Regulation Of Membrane Tubulation Integrin-mediated Signaling Pathway Cytosol Small GTPase-mediated Signal Transduction Receptor-mediated Endocytosis Regulation Of Plasma Membrane Bounded Cell Projection Organization Establishment Of Localization In Cell Regulation Of Cell Projection Organization Regulation Of Vesicle Size Fc Receptor Signaling Pathway Glutamatergic Synapse Vesicle Localization Growth Cone Filopodium Cytoplasm Response To Growth Factor Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Early Endosome Cell Projection Organization Regulation Of Leukocyte Migration Fc Receptor Mediated Stimulatory Signaling Pathway Endocytic Vesicle Positive Regulation Of Cell Projection Organization Regulation Of Receptor Internalization	Clathrin-coated Pit Endocytosis Import Into Cell Vesicle-mediated Transport Clathrin Binding Receptor-mediated Endocytosis Phospholipid Binding Clathrin Coat Assembly Extrinsic Component Of Presynaptic Endocytic Zone Membrane Cytoplasmic Vesicle Vesicle-mediated Transport In Synapse Synaptic Vesicle Endocytosis Presynaptic Endocytosis Synaptic Vesicle Regulation Of Endocytosis Early Endosome Clathrin-coated Vesicle Regulation Of Vesicle-mediated Transport Establishment Of Localization In Cell Clathrin-dependent Endocytosis Synapse Regulation Of Receptor-mediated Endocytosis Cellular Response To Growth Factor Stimulus Endosome Postsynaptic Neurotransmitter Receptor Internalization Response To Growth Factor Plasma Membrane Postsynaptic Endocytic Zone Cytoplasmic Vesicle Membrane Intracellular Transport Clathrin Heavy Chain Binding Vesicle Regulation Of Transport AP-2 Adaptor Complex Organelle Organization Presynapse Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Clathrin Adaptor Activity Regulation Of Multicellular Organismal Development Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Cellular Component Organization Cellular Localization Negative Regulation Of Blood Circulation Regulation Of Developmental Process Insulin Receptor Binding Membrane Regulation Of Cellular Component Organization Positive Regulation Of Transport Membrane Coat Chemical Synaptic Transmission