BIN1 and ASAP2

Number of citations of the paper that reports this interaction (PMID 15483625)
12

Data Source:
HPRD (in vitro)

		BIN1	ASAP2
Gene Name		bridging integrator 1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Synaptic Vesicle Actin Cytoskeleton Membrane Z Disc T-tubule Axon I Band Node Of Ranvier Axon Initial Segment Varicosity Axon Terminus Cerebellar Mossy Fiber Lipid Tube	Plasma Membrane Golgi Cisterna Membrane
	Molecular Function	Protein Binding Protein Complex Binding Identical Protein Binding Protein Heterodimerization Activity Tau Protein Binding GTPase Binding RNA Polymerase Binding	Protein Binding Enzyme Activator Activity ARF GTPase Activator Activity Zinc Ion Binding
	Biological Process	Endocytosis Cell Proliferation Viral Process Muscle Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis Positive Regulation Of Astrocyte Differentiation Lipid Tube Assembly Regulation Of Cell Cycle Arrest	Regulation Of ARF GTPase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease ( 22832961 21460840 21627779 22005930) Alzheimer's disease (late onset) ( 21460841 21390209)
Protein-Protein Interactions		36 interactors: ABL1 AMPH AP2A1 AP2A2 APP ASAP2 ATXN2 CUX1 DLGAP4 DNM1 DNM2 FBP1 ITGA1 ITGA3 ITGA6 MAP4K3 MBNL1 MYC PLD1 PLD2 PTK2 RAP1A RFX3 RIN2 RIN3 SH3GL2 SH3GLB1 SNX4 SOS1 SOS2 SYN1 SYNJ1 TP73 UBC XRCC4 ZBTB3	13 interactors: ARF1 ARF5 ARF6 BIN1 GRB2 ITSN1 PACSIN3 PTK2B PXN RAN REPS2 SH3KBP1 THSD7A
Entrez ID		274	8853
HPRD ID		03150	04820
Ensembl ID		ENSG00000136717	ENSG00000151693
Uniprot IDs		B7Z6Y2 O00499 Q9BTH3	O43150
PDB IDs		1MUZ 1MV0 1MV3 2FIC 2RMY 2RND
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Endocytosis Generation Of Neurons Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Projection Organization Regulation Of ERBB Signaling Pathway Neurogenesis Neuron Projection Morphogenesis Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Signal Transduction Axon Guidance Neuron Differentiation Neuron Development Nervous System Development Vesicle-mediated Transport Chemotaxis Signaling Neuron Projection Development Locomotion Cell Communication Anatomical Structure Morphogenesis Cell Morphogenesis Axonogenesis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Axon Development Negative Regulation Of Signaling Cell Differentiation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of ERBB Signaling Pathway Regulation Of Cellular Process Cell Development Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin Signaling Pathway System Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Cell Morphogenesis Involved In Differentiation Regulation Of Catalytic Activity Regulation Of Intracellular Signal Transduction Movement Of Cell Or Subcellular Component Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Positive Regulation Of Apoptotic Process Blood Coagulation	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Endocytosis Enzyme Linked Receptor Protein Signaling Pathway Cytoskeleton Organization Cell Projection Organization Endocytosis Intracellular Signal Transduction Transport Positive Regulation Of Actin Filament Polymerization Signal Complex Assembly Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein Polymerization Regulation Of Vesicle-mediated Transport Signal Transduction Regulation Of Actin Filament-based Process Movement Of Cell Or Subcellular Component Signaling Regulation Of Cell Shape Cell Communication Focal Adhesion Assembly Positive Regulation Of Protein Complex Assembly Cell Differentiation Regulation Of Actin Filament Polymerization Regulation Of Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Viral Process Regulation Of Actin Filament Length Adherens Junction Assembly Negative Regulation Of Endocytosis Cell-substrate Junction Assembly Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Cellular Response To Stimulus Regulation Of Signaling Organelle Organization Positive Regulation Of Cellular Component Biogenesis Establishment Of Organelle Localization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Adherens Junction Organization Positive Regulation Of Metabolic Process Generation Of Neurons
Tagcloud ?		a2m algorithm allele alzheimer amplicons apoe apoj biochip clut combinations cr1 determina e3 e4 epsilon2 epsilon4 exoc3l2 gab2 genotyping immobilized microchip oligonucleotides picalm predis rs11136000 sporadic studying tion tomm40	affy cdkn2a coexpressed coexpression constructed contructed david degs differential differentially disturbed dlk1 downloaded enrichment exploring gse26966 hub inositol itga4 mpp2 network networks obvious omnibus package phosphatidylinositol pituitary screened software
Tagcloud (Difference) ?		a2m algorithm allele alzheimer amplicons apoe apoj biochip clut combinations cr1 determina e3 e4 epsilon2 epsilon4 exoc3l2 gab2 genotyping immobilized microchip oligonucleotides picalm predis rs11136000 sporadic studying tion tomm40	affy cdkn2a coexpressed coexpression constructed contructed david degs differential differentially disturbed dlk1 downloaded enrichment exploring gse26966 hub inositol itga4 mpp2 network networks obvious omnibus package phosphatidylinositol pituitary screened software
Tagcloud (Intersection) ?