BIN1 and SNAPIN

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		BIN1	SNAPIN
Description		bridging integrator 1	SNAP associated protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Synaptic Vesicle Actin Cytoskeleton Membrane Z Disc T-tubule Axon Dendrite I Band Vesicle Node Of Ranvier Axon Initial Segment Varicosity Axon Terminus Cerebellar Mossy Fiber Lipid Tube RNA Polymerase II Transcription Repressor Complex Extrinsic Component Of Synaptic Vesicle Membrane Glutamatergic Synapse	Golgi Membrane Acrosomal Vesicle Manchette Cytoplasm Lysosome Lysosomal Membrane Golgi Apparatus Cytosol Synaptic Vesicle Membrane Secretory Granule Synaptic Vesicle Membrane BLOC-1 Complex Cytoplasmic Vesicle Synapse Perinuclear Region Of Cytoplasm Cytoplasmic Side Of Lysosomal Membrane BORC Complex Axon Cytoplasm Microvesicle
	Molecular Function	Protease Binding Protein Binding Phospholipid Binding Lipid Binding Aspartic-type Endopeptidase Inhibitor Activity Clathrin Binding Identical Protein Binding Protein-containing Complex Binding Tau Protein Binding Actin Filament Binding GTPase Binding Protein-folding Chaperone Binding RNA Polymerase Binding	SNARE Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endocytosis Nucleus Organization Cytoskeleton Organization Endosome To Lysosome Transport Regulation Of Cell Cycle Process Regulation Of Endocytosis Cell Differentiation Positive Regulation Of Actin Filament Polymerization T-tubule Organization Positive Regulation Of Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Astrocyte Differentiation Establishment Of Localization In Cell Lipid Tube Assembly Regulation Of Heart Rate By Cardiac Conduction Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel	Intracellular Protein Transport Exocytosis Lysosome Organization Lysosomal Lumen Acidification Chemical Synaptic Transmission Neurotransmitter Secretion Anterograde Axonal Transport Retrograde Axonal Transport Endosome To Lysosome Transport Negative Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Synaptic Vesicle Maturation Neuron Projection Development Protein-containing Complex Localization Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Lysosome Localization Melanosome Organization Synaptic Vesicle Transport Anterograde Synaptic Vesicle Transport Regulation Of Endosome Size Protein Maturation Establishment Of Vesicle Localization Regulation Of Lysosome Size Neuron Cellular Homeostasis Organelle Transport Along Microtubule Terminal Button Organization Autophagosome Maturation Late Endosome To Lysosome Transport Positive Regulation Of Late Endosome To Lysosome Transport Regulation Of Synaptic Vesicle Exocytosis
Pathways		Clathrin-mediated endocytosis	Golgi Associated Vesicle Biogenesis
Drugs
Diseases		Centronuclear myopathy
GWAS		Alzheimer's disease ( 21460840 31473137 21627779 22832961) Alzheimer's disease (late onset) ( 28714976 30617256 21390209 21460841 24162737) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 33589840 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Creatine kinase levels ( 29403010) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Family history of Alzheimer's disease ( 30617256) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Neuritic plaques or neurofibrillary tangles (pleiotropy) ( 29458411) Neurofibrillary tangles ( 25188341) Neutrophil count ( 32888494) Pelvic organ prolapse (moderate/severe) ( 26545240) Psychosis and Alzheimer's disease ( 22005930) Systemic lupus erythematosus ( 24871463)
Interacting Genes		48 interacting genes: ABL1 ACTA1 ACTG1 AMPH AP2A1 AP2A2 APP APPL1 ASAP2 ATXN2 CLIP1 CUX1 DLGAP4 DNM1 DNM2 E2F1 FBP1 FHL2 HUNK ITCH ITGA1 ITGA3 ITGA6 MAP4K3 MBNL1 MYC PDK1 PLD1 PLD2 PTGER4 PTK2 RAP1A RFX3 RIN2 RIN3 SH3GL2 SH3GLB1 SNAPIN SNX4 SOS1 SOS2 SYN1 SYNJ1 TP73 UBC WASL XRCC4 ZBTB3	103 interacting genes: ABI2 ACTN2 ATG14 ATP1A1 BANP BFSP1 BFSP2 BIN1 BLOC1S1 BLOC1S2 BLOC1S4 BLOC1S5 BLOC1S6 BNIPL C20orf202 CCDC102B CDC42BPA CEP170 CMYA5 CSNK1D DDR1 DENND1C DES DNM2 DOCK9 DST DTNBP1 DYRK3 DYSF EBAG9 EEF1G ELP1 ENO3 EXOC7 FAM114A1 FSD2 GPRASP1 GRIK1 HAP1 HMGB2 IKBIP IMMT KANK2 KAT5 KAT7 KIF5C KPNB1 KRT10 KRT15 KRT16 KRT17 KRT19 KRT20 KRT24 KRT26 LAMA2 LAMC1 LMNB1 LRP12 MACF1 MAPK14 MET MORC3 MTNR1A MYH14 MYH3 MYH7 NECAB2 NEDD9 NME7 NUP62CL PCYT1A PLAC9 PLEC PRKACA RABEP1 RABGEF1 RETREG1 RGS7 RNF13 SHBG SKA1 SMAD2 SMG1 SNAP23 SNAP25 SPAG5 SPP1 SPTB SPTBN1 ST7 TFIP11 TOMM70 TPM1 TPM2 TPM3 TPM4 TRIM63 TRPV1 TSG101 WASHC3 YWHAE YWHAZ
Entrez ID		274	23557
HPRD ID		03150	06111
Ensembl ID		ENSG00000136717	ENSG00000143553
Uniprot IDs		B7Z2Z2 B7Z6Y2 O00499 Q9BTH3	O95295
PDB IDs		1MUZ 1MV0 1MV3 2FIC 2RMY 2RND 5I22
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Regulation Of Vesicle-mediated Transport Endocytosis Vesicle-mediated Transport In Synapse Vesicle-mediated Transport Cytoplasmic Vesicle Import Into Cell Regulation Of Endocytosis Presynapse Synaptic Vesicle Endocytosis Regulation Of Plasma Membrane Organization Presynaptic Endocytosis Positive Regulation Of Cellular Component Organization Protein Kinase Binding Regulation Of Transport Regulation Of Receptor-mediated Endocytosis Receptor Internalization Clathrin-coated Pit Endocytic Vesicle Membrane Plasma Membrane Perinuclear Region Of Cytoplasm Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of Hematopoietic Progenitor Cell Differentiation Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Vesicle Scission Negative Regulation Of Membrane Tubulation Integrin-mediated Signaling Pathway Cytosol Small GTPase-mediated Signal Transduction Receptor-mediated Endocytosis Regulation Of Plasma Membrane Bounded Cell Projection Organization Establishment Of Localization In Cell Regulation Of Cell Projection Organization Regulation Of Vesicle Size Fc Receptor Signaling Pathway Glutamatergic Synapse Vesicle Localization Growth Cone Filopodium Cytoplasm Response To Growth Factor Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Early Endosome Cell Projection Organization Regulation Of Leukocyte Migration Fc Receptor Mediated Stimulatory Signaling Pathway Endocytic Vesicle Positive Regulation Of Cell Projection Organization Regulation Of Receptor Internalization	Cytoskeleton Organization Cytoskeleton Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Organelle Organization Intermediate Filament Organization Establishment Of Organelle Localization Intermediate Filament Supramolecular Fiber Organization Organelle Localization Structural Constituent Of Cytoskeleton BLOC-1 Complex Actin Filament Binding Synaptic Vesicle Transport Establishment Of Vesicle Localization Structural Molecule Activity Axo-dendritic Transport Axon Cytoplasm Axonal Transport Vesicle Localization Establishment Of Localization In Cell Anterograde Axonal Transport Cytosol Anterograde Synaptic Vesicle Transport Muscle Thin Filament Tropomyosin Structural Constituent Of Skin Epidermis Cytoplasm Transport Along Microtubule Vesicle Transport Along Microtubule Cellular Localization Cytoskeleton-dependent Intracellular Transport Vesicle Cytoskeletal Trafficking Regulation Of Cellular Component Organization Microtubule-based Transport Melanosome Organization Keratin Filament Intracellular Transport Pigment Granule Organization Structural Constituent Of Muscle Actomyosin Structure Organization Muscle System Process Actin Binding Muscle Contraction Extracellular Exosome Contractile Muscle Fiber Stress Fiber Organelle Transport Along Microtubule Tissue Morphogenesis Intracellular Protein Localization Z Disc
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