AHDC1 and ITSN2

Number of citations of the paper that reports this interaction (PubMedID 22558309)
58

Data Source:
BioGRID (two hybrid)

		AHDC1	ITSN2
Description		AT-hook DNA binding motif containing 1	intersectin 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Chromosome	Cytoplasm Centrosome Cytosol Plasma Membrane Presynaptic Membrane Extracellular Exosome Intracellular Vesicle
	Molecular Function	DNA Binding DNA-binding Transcription Factor Activity Protein Binding Promoter-enhancer Loop Anchoring Activity	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Metal Ion Binding
	Biological Process	Mesoderm Formation Regulation Of DNA-templated Transcription Cell Differentiation Skin Morphogenesis	Endocytosis Endosomal Transport Cell Differentiation Clathrin-dependent Synaptic Vesicle Endocytosis Positive Regulation Of Dendrite Extension
Pathways			Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOU GTPase cycle
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Myocardial infarction ( 33532862) Pulse pressure ( 30578418)	Appendicular lean mass ( 33097823) Asthma ( 29273806) Chromium levels ( 26025379) Diffuse large B cell lymphoma ( 25261932) Feeling fed-up ( 29500382) Low density lipoprotein cholesterol levels ( 32154731 33339817) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309) Sjögren's syndrome ( 24097067) Total cholesterol levels ( 33339817)
Interacting Genes		9 interacting genes: APP ATXN1 DAPK1 DOK5 H3-4 ITSN2 LRRK2 MFHAS1 ZDHHC17	74 interacting genes: AGT AHDC1 AMPH ANKRD17 BCCIP CBL CCDC88C CHIC2 CPSF6 DLGAP1 DST EGFR EPS8 ERC1 FASLG FCHSD1 FCHSD2 FNBP4 GAREM2 GOLGA2 GOLGA8A GOLGB1 GPNMB HNRNPK HOOK2 ITPKA ITSN1 KCTD10 KDM1A KHDRBS1 KIAA1549 KXD1 LSM8 LTBP4 LUC7L3 MAP4K3 MBNL1 MEGF10 NBR1 NR2C2 PDCD6IP PDE4DIP PIK3AP1 PIK3C2B PSEN1 PTN RAD9A RBMX REPS1 RNF20 ROCK1 RUFY1 SEMA6A SH3GL1 SH3KBP1 SNAP29 SNCA SOS1 SOS2 STX4 SYN1 SYNJ2 TACC1 TBL3 TMF1 TRIO UBC WAS WASF2 WASL WIPF1 WIPF2 YLPM1 YTHDF1
Entrez ID		27245	50618
HPRD ID		10885	09193
Ensembl ID		ENSG00000126705	ENSG00000198399
Uniprot IDs		Q5TGY3	A6H8W8 Q9NZM3
PDB IDs			1J3T 1UDL 1UE9 1UFF 1UHF 3GF9 3JZY 4IIO
Enriched GO Terms of Interacting Partners?		Cellular Response To Manganese Ion Regulation Of MAPK Cascade Regulation Of Neurotrophin TRK Receptor Signaling Pathway Golgi-associated Vesicle Positive Regulation Of MAPK Cascade Cellular Response To Catecholamine Stimulus Response To Catecholamine Response To Manganese Ion Syntaxin-1 Binding Locomotory Behavior Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Postsynapse Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Cell Projection Morphogenesis Growth Cone Lamellipodium Regulation Of Synapse Organization Visual Behavior Regulation Of Response To Calcium Ion Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Amylin Binding Neuron Projection Morphogenesis Positive Regulation Of Toll Signaling Pathway Visual Learning Regulation Of CAMP/PKA Signal Transduction Regulation Of Cell Communication Modulation Of Excitatory Postsynaptic Potential Regulation Of Signaling DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Excitatory Postsynaptic Potential Regulation Of Macrophage Activation Perforant Pathway To Dendrate Granule Cell Synapse Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Positive Regulation Of Signal Transduction GTP Binding Acetylcholine Receptor Activator Activity Adult Locomotory Behavior Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Inflammatory Response Regulation Of Calcium-mediated Signaling	SH3 Domain Binding Endocytosis Cell Projection Vesicle-mediated Transport Actin Filament-based Movement Import Into Cell Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Establishment Of Localization In Cell Cytoskeleton Positive Regulation Of Cellular Component Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Cytoplasmic Vesicle Cytoskeleton Organization Small GTPase-mediated Signal Transduction Cytoplasm Synaptic Vesicle Endocytosis Organelle Localization Glutamatergic Synapse Presynaptic Endocytosis Actin Binding Vesicle-mediated Transport In Synapse Organelle Organization Supramolecular Fiber Organization Cadherin Binding Actin Filament-based Process Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Communication Regulation Of Signaling Cellular Localization Regulation Of Cellular Component Organization Regulation Of Cytoskeleton Organization Membrane Organization MRNA Binding Protein Complex Oligomerization Regulation Of Vesicle-mediated Transport Regulation Of Angiotensin-activated Signaling Pathway Intracellular Transport Apical Constriction Positive Regulation Of RNA Export From Nucleus Cellular Component Assembly Cytosol Actin Cytoskeleton Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Synaptic Plasticity Cell-cell Signaling Regulation Of Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission
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