DISC1 and SPTBN4

Number of citations of the paper that reports this interaction (PubMedID 12506198)
31

Data Source:
HPRD (two hybrid, in vivo)

		DISC1	SPTBN4
Description		DISC1 scaffold protein	spectrin beta, non-erythrocytic 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Kinesin Complex Microtubule Synaptic Vesicle Postsynaptic Density Dynein Complex Axon Ciliary Basal Body Cell Body Intermediate Filament Cytoskeleton Synapse Perinuclear Region Of Cytoplasm Central Region Of Growth Cone Ciliary Base Presynapse Glutamatergic Synapse GABA-ergic Synapse	Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Adherens Junction Cell Cortex Spectrin Intercalated Disc Membrane Nuclear Matrix PML Body Cell Junction Axon Cortical Actin Cytoskeleton Node Of Ranvier Paranode Region Of Axon Cell Projection Neuronal Cell Body Axon Initial Segment Axon Hillock Juxtaparanode Region Of Axon Extracellular Exosome Cell Body Fiber
	Molecular Function	Protein Binding Kinesin Binding Identical Protein Binding Protein-containing Complex Binding Molecular Adaptor Activity	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Phosphatase Binding Ankyrin Binding Spectrin Binding Actin Filament Binding Cytoskeletal Protein-membrane Anchor Activity
	Biological Process	Microtubule Cytoskeleton Organization Neuron Migration Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Neuroblast Proliferation Ubiquitin-dependent Protein Catabolic Process Nervous System Development Intracellular Protein Localization Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Cerebral Cortex Radially Oriented Cell Migration Cell Proliferation In Forebrain Pyramidal Neuron Migration To Cerebral Cortex Positive Regulation Of Wnt Signaling Pathway TOR Signaling Positive Regulation Of Axon Extension Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Mitochondrial Calcium Ion Homeostasis Response To Electrical Stimulus Regulation Of Synaptic Transmission, Glutamatergic Canonical Wnt Signaling Pathway Cilium Assembly Regulation Of Dendritic Spine Development Neuron Cellular Homeostasis Protein Localization To Centrosome Regulation Of Synapse Maturation Regulation Of Postsynapse Organization Non-motile Cilium Assembly Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Regulation Of Sodium Ion Transport Axonogenesis Neuromuscular Junction Development Sensory Perception Of Sound Adult Walking Behavior Intracellular Protein Localization Fertilization Negative Regulation Of Heart Rate Vesicle-mediated Transport Transmission Of Nerve Impulse Central Nervous System Projection Neuron Axonogenesis Actin Cytoskeleton Organization Adult Behavior Positive Regulation Of Multicellular Organism Growth Clustering Of Voltage-gated Sodium Channels Neuromuscular Process Actin Filament Capping Cardiac Conduction Protein-containing Complex Assembly Protein Localization To Plasma Membrane
Pathways			NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
Drugs
Diseases
GWAS		Alzheimer's disease ( 19118814) Amyotrophic lateral sclerosis ( 19451621) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arterial stiffness index ( 31235810) Bell's palsy ( 33602968) Chronic periodontitis (mean interproximal clinical attachment level) ( 27601451) Metabolite levels ( 23823483) Neuranatomic and neurocognitive phenotypes ( 21483430) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to antidepressants (symptom improvement) ( 29160301) Response to antineoplastic agents ( 21659360) Response to statin therapy ( 20339536) Serum docosahexaenoic fatty acid concentration in metabolic syndrome ( 31991592) Waist circumference ( 28552196)	Antibody level in response to infection ( 25758998) Carotid intima media thickness (mean) ( 31801372) Hemoglobin levels ( 32327693) Pulse pressure ( 30578418)
Interacting Genes		183 interacting genes: ABI2 ACTG1 ACTN2 ADO AGTPBP1 AIMP2 AIRIM AKAP6 AMOT AP1M1 ARIH2 ARMC7 ATF4 ATF5 ATF7IP BAG2 BFSP2 BICD1 BRD1 C8orf33 CARD9 CATSPERT CCDC102B CCDC13 CCDC136 CCDC141 CCDC197 CCDC24 CCDC57 CCDC88A CCDC92 CCHCR1 CDC23 CDC37 CDC5L CDK5RAP3 CDKL3 CEP126 CEP57L1 CEP63 CFAP206 CIT CLU COL4A1 CRMP1 CTNNA3 CWF19L2 DCTN1 DCTN2 DDX6 DMD DNAJC7 DPYSL2 DPYSL3 DRC4 DST DYNC1H1 EEF2 EIF3H EIF4A3 EMSY EXOC1 EXOC4 EXOC7 FBXO34 FBXO41 FBXW7 FEZ1 FLACC1 FRYL GABARAPL1 GAS2L2 GCC1 GEM GNB1 GNG13 GNPTAB GPANK1 GPRASP2 GRIPAP1 GSK3B HERC2P2 HNRNPC IFT74 IMMT ITSN1 KALRN KANSL1 KCNQ5 KIF3A KIF3C KIF9 KIFAP3 KIFC3 LENG1 MACF1 MAP1A MEMO1 MLLT10 MNS1 MORF4L2 MPPED1 MVP MYH7 MYT1L NCK2 NDE1 NDEL1 NECAB1 NEFM NME7 NSRP1 NUP160 OLFM1 PCNT PCNX4 PGK1 PHF1 PIBF1 PIK3R3 PKN1 POLR3C PPFIA3 PPM1E PPP4R1 PPP5C PSPC1 QARS1 RABGAP1 RAD21 RANBP9 RASSF7 RBM41 RBSN RECK ROGDI RTRAF SH3BP5 SMARCD1 SMARCE1 SMC2 SMC3 SMC5 SMYD1 SNX6 SPARCL1 SPATC1L SPTBN4 SRGAP2 SRGAP3 STX11 STX18 SUFU SYBU SYNE1 TCAF1 TCEANC TFIP11 TIAM2 TRAF3IP1 TRAF4 TRIM29 TRIM68 TRIO TSGA10 TSPOAP1 TSR2 TTC23 TUBB TUBB2A UBASH3A UBASH3B USP2 UTRN XPNPEP1 YWHAE YWHAG YWHAQ YWHAZ ZNF124 ZNF197 ZNF365 ZNF76	18 interacting genes: ANK3 ARC CDC37 CDKL5 CELSR3 CENPU CFAP298 CLK1 DISC1 GADD45A GSK3B MORC3 NEK2 PFDN1 PTPRN PTPRN2 RPS6KA6 SPTAN1
Entrez ID		27185	57731
HPRD ID		05553	09372
Ensembl ID		ENSG00000162946	ENSG00000160460
Uniprot IDs		C4P094 C4P096 C4P098 C4P0A4 C4P0A5 C4P0C4 C4P0C8 C4P0D0 C4P0D1 C4P0D2 C4P0D3 Q9NRI5	Q9H254
PDB IDs		5V4B
Enriched GO Terms of Interacting Partners?		Cytoskeleton Centrosome Microtubule Cytoplasm Microtubule-based Process Protein Binding Microtubule Cytoskeleton Organization Organelle Organization Cytosol Cytoskeleton-dependent Intracellular Transport Cytoskeleton Organization Microtubule-based Movement Microtubule Binding Transport Along Microtubule Microtubule-based Transport Organelle Localization Axo-dendritic Transport Identical Protein Binding Axonal Transport Kinesin Complex Regulation Of Microtubule-based Process Regulation Of Organelle Organization Retrograde Axonal Transport Cell Projection Organization Cell Projection Assembly Cytoskeletal Anchor Activity Regulation Of Cellular Component Organization Developmental Process Cilium Axon Cytoplasm Cell Projection Tau Protein Binding Plasma Membrane Bounded Cell Projection Assembly Ciliary Basal Body Ciliary Tip Organelle Assembly Microtubule Cytoskeleton Organization Involved In Mitosis Centriole Structural Constituent Of Cytoskeleton Microtubule Nucleation Nervous System Development Dihydropyrimidinase Activity Cilium Organization Positive Regulation Of Protein Localization To Cilium Negative Regulation Of Protein Phosphorylation Negative Regulation Of Protein Metabolic Process Synapse Ubiquitin Protein Ligase Binding Plasma Membrane Bounded Cell Projection Organization Establishment Of Organelle Localization	Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity TOR Signaling Regulation Of Axon Extension Insulin Secretion Involved In Cellular Response To Glucose Stimulus Protein Kinase Activity Spectrin Binding Cytoskeleton Kinase Activity Regulation Of Axonogenesis Centrosome Ciliary Basal Body Regulation Of Postsynapse Organization Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Axon Cell Projection Organization Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Neuron Projection Organization Peptidyl-serine Phosphorylation Regulation Of Long-term Synaptic Potentiation Regulation Of Microtubule Anchoring At Centrosome Regulation Of Neuron Projection Development Negative Regulation Of Centriole-centriole Cohesion Positive Regulation Of Axon Extension Virus-like Capsid Insulin Secretion Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Cell Projection Maintenance Of Protein Location Maintenance Of Protein Location In Cell Maintenance Of Protein Location In Plasma Membrane Regulation Of Anatomical Structure Morphogenesis Plasma Membrane Bounded Cell Projection Organization Regulation Of Dendrite Morphogenesis Positive Regulation Of Cell-matrix Adhesion Superior Temporal Gyrus Development Modulation Of Chemical Synaptic Transmission Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Transport Vesicle Membrane HSP90-CDC37 Chaperone Complex Negative Regulation Of Embryonic Development Organelle Organization Positive Regulation Of Cell Communication By Electrical Coupling Cell Projection Morphogenesis Cytoskeleton Organization Regulation Of Biological Quality Neuron Projection Morphogenesis Synapse
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