DISC1 and SMC3

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		DISC1	SMC3
Gene Name		disrupted in schizophrenia 1	structural maintenance of chromosomes 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Centrosome Microtubule Postsynaptic Density Cell Junction Ciliary Basal Body Postsynaptic Membrane	Chromosome, Centromeric Region Chromatin Lateral Element Spindle Pole Basement Membrane Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Cohesin Complex Cohesin Core Heterodimer Nuclear Matrix Meiotic Cohesin Complex Nuclear Meiotic Cohesin Complex
	Molecular Function	Protein Binding	Chromatin Binding Microtubule Motor Activity Protein Binding ATP Binding Mediator Complex Binding Dynein Binding Protein Heterodimerization Activity
	Biological Process	Microtubule Cytoskeleton Organization Neuron Migration Positive Regulation Of Neuroblast Proliferation Regulation Of Neuron Projection Development Cerebral Cortex Radially Oriented Cell Migration Cell Proliferation In Forebrain Positive Regulation Of Wnt Signaling Pathway TOR Signaling Cellular Protein Localization Mitochondrial Calcium Ion Homeostasis Canonical Wnt Signaling Pathway Regulation Of Synapse Maturation Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Mitotic Cell Cycle Regulation Of DNA Replication DNA Repair Mitotic Spindle Organization Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Mitotic Nuclear Division Meiotic Nuclear Division Signal Transduction Stem Cell Maintenance Negative Regulation Of DNA Endoreduplication Cell Division
Pathways			Establishment of Sister Chromatid Cohesion Mitotic Prometaphase Mitotic Telophase/Cytokinesis Separation of Sister Chromatids Meiotic synapsis Cohesin Loading onto Chromatin Mitotic Anaphase S Phase M Phase Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS		Alzheimer's disease ( 19118814) Amyotrophic lateral sclerosis ( 19451621) Neuranatomic and neurocognitive phenotypes ( 21483430) Response to antineoplastic agents ( 21659360) Response to statin therapy ( 20339536)
Protein-Protein Interactions		113 interactors: ACTG1 ACTN2 AGTPBP1 AKAP6 AKAP9 ARIH2 ATF4 ATF5 ATF7IP BICD1 BZRAP1 C14orf166 CCDC136 CCDC141 CCDC24 CCDC88A CDC5L CDK5RAP3 CEP170 CEP57L1 CEP63 CIT CLU COL4A1 DCTN1 DCTN2 DMD DNAJC7 DPYSL2 DPYSL3 DST DYNC1H1 EEF2 EIF3H EXOC1 EXOC4 EXOC7 FBXO41 FEZ1 FRYL GNB1 GNPTAB GPRASP2 HERC2P2 IFT20 IMMT ITSN1 KALRN KANSL1 KCNQ5 KIAA1377 KIF3A KIF3C KIFAP3 MACF1 MAP1A MATR3 MEMO1 MLLT10 MPPED1 MVP MYO1A MYT1L NDE1 NDEL1 NEFM NUP160 OLFM1 PAFAH1B1 PCNT PCNXL4 PDE4B PGK1 PPM1E PPP4R1 PPP5C RABGAP1 RAD21 RANBP9 RASSF7 RBSN ROGDI SH3BP5 SMARCE1 SMC2 SMC3 SNX6 SPARCL1 SPTAN1 SPTBN1 SPTBN4 SRGAP2 SRGAP3 STX18 SYBU SYNE1 TFIP11 TIAM2 TNIK TNKS TRAF3IP1 TRIO TUBB TUBB2A UTRN XPNPEP1 XRN2 YWHAE YWHAG YWHAQ YWHAZ ZNF197 ZNF365	14 interactors: APC CEP63 DISC1 FEZ1 FEZ2 KIFAP3 MXD1 MXD3 MXD4 MXI1 RPGR SMC1A SMC1B TRAF3IP1
Entrez ID		27185	9126
HPRD ID		05553	05829
Ensembl ID		ENSG00000162946	ENSG00000108055
Uniprot IDs		C4P094 C4P096 C4P098 C4P0A4 C4P0A5 C4P0C4 C4P0C8 C4P0D0 C4P0D1 C4P0D2 C4P0D3 Q9NRI5	Q9UQE7
PDB IDs
Enriched GO Terms of Interacting Partners?		Organelle Organization Movement Of Cell Or Subcellular Component Cellular Localization Microtubule-based Process Nervous System Development Establishment Of Localization In Cell Neurogenesis G2/M Transition Of Mitotic Cell Cycle Generation Of Neurons Microtubule Cytoskeleton Organization Cytoskeleton-dependent Intracellular Transport Mitotic Cell Cycle Process Cellular Component Assembly Cell Projection Organization Mitotic Cell Cycle Microtubule-based Transport Cell Cycle Process Organelle Localization Cytoskeleton Organization Cell Cycle Cell Projection Morphogenesis Cell Part Morphogenesis Anatomical Structure Development System Development Membrane Organization Cell Differentiation Cell Morphogenesis Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Organelle Transport Along Microtubule Developmental Process Protein Localization Microtubule-based Movement Axonogenesis Mitotic Nuclear Division Locomotion Establishment Of Organelle Localization Axon Guidance Vesicle Localization Axon Development Neuron Development Cellular Process Regulation Of Cellular Component Organization Multicellular Organismal Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Neurogenesis Cell Projection Assembly Neuron Differentiation Intracellular Transport Spindle Organization	Microtubule-based Process Movement Of Cell Or Subcellular Component Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Negative Regulation Of Cellular Metabolic Process Cell Projection Morphogenesis Cell Part Morphogenesis Microtubule Cytoskeleton Organization Sister Chromatid Cohesion Organelle Organization Intraciliary Transport Cell Morphogenesis Cell Cycle Checkpoint Cell Projection Organization Negative Regulation Of Cell Proliferation Positive Regulation Of Calcium-dependent Cell-cell Adhesion Cell Cycle Mitotic Nuclear Division Negative Regulation Of Biosynthetic Process Microtubule-based Movement Regulation Of Cell Proliferation Nervous System Development Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Signal Transduction In Response To DNA Damage Canonical Wnt Signaling Pathway Generation Of Neurons Eye Development Cellular Localization Cell Division Neuron Development Neurogenesis Negative Regulation Of Odontogenesis Organelle Assembly Cell Cycle Process Spindle Organization Regulation Of Cell Projection Organization Cell Development Negative Regulation Of DNA Endoreduplication Negative Regulation Of Transcription, DNA-templated Axonogenesis Negative Regulation Of Nucleic Acid-templated Transcription Cytoskeleton Organization Neuron Differentiation Cellular Component Assembly Negative Regulation Of RNA Biosynthetic Process Plus-end-directed Vesicle Transport Along Microtubule Stem Cell Maintenance Positive Regulation Of Wnt Signaling Pathway Metaphase/anaphase Transition Of Mitotic Cell Cycle Axon Development
Tagcloud ?		accelerate aggregated allosteric amplify appropriated assemblies assembly biochemically capsid catalytically collections commonality conceptualized continuum crowded exploit governed labile machines multimers multiprotein pathologically prions replicating replicative reprogrammed reset suited transmissibility	12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing espl1 exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem nipbl novo partitioning rad21 recursive separase smc1a undetected
Tagcloud (Difference) ?		accelerate aggregated allosteric amplify appropriated assemblies assembly biochemically capsid catalytically collections commonality conceptualized continuum crowded exploit governed labile machines multimers multiprotein pathologically prions replicating replicative reprogrammed reset suited transmissibility	12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing espl1 exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem nipbl novo partitioning rad21 recursive separase smc1a undetected
Tagcloud (Intersection) ?