DISC1 and TRIO

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		DISC1	TRIO
Gene Name		disrupted in schizophrenia 1	trio Rho guanine nucleotide exchange factor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Centrosome Microtubule Postsynaptic Density Cell Junction Ciliary Basal Body Postsynaptic Membrane	Cytosol
	Molecular Function	Protein Binding	Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Enzyme Binding
	Biological Process	Microtubule Cytoskeleton Organization Neuron Migration Positive Regulation Of Neuroblast Proliferation Regulation Of Neuron Projection Development Cerebral Cortex Radially Oriented Cell Migration Cell Proliferation In Forebrain Positive Regulation Of Wnt Signaling Pathway TOR Signaling Cellular Protein Localization Mitochondrial Calcium Ion Homeostasis Canonical Wnt Signaling Pathway Regulation Of Synapse Maturation Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways			G alpha (q) signalling events Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE DCC mediated attractive signaling p75 NTR receptor-mediated signalling Rho GTPase cycle G alpha (q) signalling events GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK NRAGE signals death through JNK Signaling by Rho GTPases G alpha (12/13) signalling events Netrin-1 signaling
Drugs
Diseases
GWAS		Alzheimer's disease ( 19118814) Amyotrophic lateral sclerosis ( 19451621) Neuranatomic and neurocognitive phenotypes ( 21483430) Response to antineoplastic agents ( 21659360) Response to statin therapy ( 20339536)	Paclitaxel-induced neuropathy ( 23776197)
Protein-Protein Interactions		113 interactors: ACTG1 ACTN2 AGTPBP1 AKAP6 AKAP9 ARIH2 ATF4 ATF5 ATF7IP BICD1 BZRAP1 C14orf166 CCDC136 CCDC141 CCDC24 CCDC88A CDC5L CDK5RAP3 CEP170 CEP57L1 CEP63 CIT CLU COL4A1 DCTN1 DCTN2 DMD DNAJC7 DPYSL2 DPYSL3 DST DYNC1H1 EEF2 EIF3H EXOC1 EXOC4 EXOC7 FBXO41 FEZ1 FRYL GNB1 GNPTAB GPRASP2 HERC2P2 IFT20 IMMT ITSN1 KALRN KANSL1 KCNQ5 KIAA1377 KIF3A KIF3C KIFAP3 MACF1 MAP1A MATR3 MEMO1 MLLT10 MPPED1 MVP MYO1A MYT1L NDE1 NDEL1 NEFM NUP160 OLFM1 PAFAH1B1 PCNT PCNXL4 PDE4B PGK1 PPM1E PPP4R1 PPP5C RABGAP1 RAD21 RANBP9 RASSF7 RBSN ROGDI SH3BP5 SMARCE1 SMC2 SMC3 SNX6 SPARCL1 SPTAN1 SPTBN1 SPTBN4 SRGAP2 SRGAP3 STX18 SYBU SYNE1 TFIP11 TIAM2 TNIK TNKS TRAF3IP1 TRIO TUBB TUBB2A UTRN XPNPEP1 XRN2 YWHAE YWHAG YWHAQ YWHAZ ZNF197 ZNF365	11 interactors: BLMH CDC5L DISC1 EXOC1 FLNA ITSN2 MAPRE1 PTK2 PTPRF RAC1 RHOA
Entrez ID		27185	7204
HPRD ID		05553	03537
Ensembl ID		ENSG00000162946	ENSG00000038382
Uniprot IDs		C4P094 C4P096 C4P098 C4P0A4 C4P0A5 C4P0C4 C4P0C8 C4P0D0 C4P0D1 C4P0D2 C4P0D3 Q9NRI5	O75962
PDB IDs			1NTY 2NZ8
Enriched GO Terms of Interacting Partners?		Organelle Organization Movement Of Cell Or Subcellular Component Cellular Localization Microtubule-based Process Nervous System Development Establishment Of Localization In Cell Neurogenesis G2/M Transition Of Mitotic Cell Cycle Generation Of Neurons Microtubule Cytoskeleton Organization Cytoskeleton-dependent Intracellular Transport Mitotic Cell Cycle Process Cellular Component Assembly Cell Projection Organization Mitotic Cell Cycle Microtubule-based Transport Cell Cycle Process Organelle Localization Cytoskeleton Organization Cell Cycle Cell Projection Morphogenesis Cell Part Morphogenesis Anatomical Structure Development System Development Membrane Organization Cell Differentiation Cell Morphogenesis Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Organelle Transport Along Microtubule Developmental Process Protein Localization Microtubule-based Movement Axonogenesis Mitotic Nuclear Division Locomotion Establishment Of Organelle Localization Axon Guidance Vesicle Localization Axon Development Neuron Development Cellular Process Regulation Of Cellular Component Organization Multicellular Organismal Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Neurogenesis Cell Projection Assembly Neuron Differentiation Intracellular Transport Spindle Organization	Platelet Activation Positive Regulation Of Signal Transduction Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Migration Cell Motility Blood Coagulation Hemostasis Microtubule Cytoskeleton Organization Mitotic Spindle Assembly Regulation Of Cell Projection Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Phosphatidylinositol 3-kinase Activity Cytoskeleton Organization Regulation Of Body Fluid Levels Wound Healing Locomotion Organelle Organization Positive Regulation Of Transcription Factor Import Into Nucleus Mitotic Spindle Organization Cell Activation Positive Regulation Of Stress Fiber Assembly Response To Wounding Regulation Of Focal Adhesion Assembly Cell Morphogenesis Involved In Differentiation Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Vesicle-mediated Transport Negative Regulation Of Axonogenesis Microtubule-based Process Cellular Localization Movement Of Cell Or Subcellular Component Regulation Of Lipid Kinase Activity Regulation Of Cell Junction Assembly Mitotic Nuclear Division Positive Regulation Of Intracellular Signal Transduction Cerebral Cortex Radially Oriented Cell Migration Regulation Of Stress Fiber Assembly Cell Projection Morphogenesis Regulation Of Rho Protein Signal Transduction Regulation Of Cell Development Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Neuron Projection Development Regulation Of Organelle Organization Regulation Of Protein Catabolic Process Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity
Tagcloud ?		accelerate aggregated allosteric amplify appropriated assemblies assembly biochemically capsid catalytically collections commonality conceptualized continuum crowded exploit governed labile machines multimers multiprotein pathologically prions replicating replicative reprogrammed reset suited transmissibility	accelerating accidents attends battlefield blades boat collisions devastating falls histories imparted inflicted observer obstacles operator propeller recreational rope shearing skier sport sporting sports tow trauma unobstructed vigorous waterskiing wounds
Tagcloud (Difference) ?		accelerate aggregated allosteric amplify appropriated assemblies assembly biochemically capsid catalytically collections commonality conceptualized continuum crowded exploit governed labile machines multimers multiprotein pathologically prions replicating replicative reprogrammed reset suited transmissibility	accelerating accidents attends battlefield blades boat collisions devastating falls histories imparted inflicted observer obstacles operator propeller recreational rope shearing skier sport sporting sports tow trauma unobstructed vigorous waterskiing wounds
Tagcloud (Intersection) ?