SPTBN4 and NEK2

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		SPTBN4	NEK2
Name		spectrin beta, non-erythrocytic 4	NIMA related kinase 2
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Adherens Junction Cell Cortex Spectrin Intercalated Disc Membrane Nuclear Matrix PML Body Cell Junction Axon Cortical Actin Cytoskeleton Node Of Ranvier Paranode Region Of Axon Cell Projection Neuronal Cell Body Axon Initial Segment Axon Hillock Juxtaparanode Region Of Axon Extracellular Exosome Cell Body Fiber	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Condensed Nuclear Chromosome Spindle Pole Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Plasma Membrane Cilium Microtubule Cytoskeleton Midbody Nuclear Lumen Protein-containing Complex Ciliary Basal Body Intercellular Bridge
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Phosphatase Binding Ankyrin Binding Spectrin Binding Actin Filament Binding Cytoskeletal Protein-membrane Anchor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of Sodium Ion Transport Axonogenesis Neuromuscular Junction Development Sensory Perception Of Sound Adult Walking Behavior Intracellular Protein Localization Fertilization Negative Regulation Of Heart Rate Vesicle-mediated Transport Transmission Of Nerve Impulse Central Nervous System Projection Neuron Axonogenesis Actin Cytoskeleton Organization Adult Behavior Positive Regulation Of Multicellular Organism Growth Clustering Of Voltage-gated Sodium Channels Neuromuscular Process Actin Filament Capping Cardiac Conduction Protein-containing Complex Assembly Protein Localization To Plasma Membrane	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Blastocyst Development Protein Phosphorylation Chromosome Segregation Regulation Of Mitotic Nuclear Division Positive Regulation Of Telomere Maintenance Regulation Of Mitotic Centrosome Separation Protein Autophosphorylation Spindle Assembly Centrosome Separation Cell Division Meiotic Cell Cycle Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic Spindle Assembly Negative Regulation Of Centriole-centriole Cohesion
Pathways		NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport	APC-Cdc20 mediated degradation of Nek2A Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 GSK3B-mediated proteasomal degradation of PD-L1(CD274)
Drugs		None	5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N,2,4-trimethyl-1H-pyrrole-3-carboxamide Fostamatinib
GWAS		Antibody level in response to infection ( 25758998 ) Carotid intima media thickness (mean) ( 31801372 ) Hemoglobin levels ( 32327693 ) Pulse pressure ( 30578418 )	Red cell distribution width ( 27863252 28957414 32888494 ) Serum alkaline phosphatase levels ( 33547301 )
Novel Interactors		None recorded	13 novel interactors: ADORA1 ARHGEF11 ATF3 CD46 CNTN2 DUSP10 FLVCR1 KCNA4 KIAA0930 NENF PLCB2 PPP2R5A PROX1
Interacting Genes		18 interacting genes: ANK3 ARC CDC37 CDKL5 CELSR3 CENPU CFAP298 CLK1 DISC1 GADD45A GSK3B MORC3 NEK2 PFDN1 PTPRN PTPRN2 RPS6KA6 SPTAN1	29 interacting genes: CDC20 CEP250 CHGA CIP2A CSN2 CTNNB1 DCTN1 EDRF1 EIF4A2 FZR1 GIT1 IFT140 IMMT MAD1L1 MAPK1 MCC NDC80 NEK11 PDE4DIP PIN1 PPP1CA PPP1CC PPP1R2 PRKN PTPRD SMURF1 SPTBN4 TCF25 TPM3
Entrez ID		57731	4751
HPRD ID		09372	04953
Ensembl ID		ENSG00000160460	ENSG00000117650
Uniprot IDs		Q9H254	F6U4U2 P51955
PDB IDs		Not available	2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK4 2XK6 2XK7 2XK8 2XKC 2XKD 2XKE 2XKF 2XNM 2XNN 2XNO 2XNP 4A4X 4AFE 5M51 5M53 5M55 5M57 6SGD 6SGH 6SGI 6SGK 6SK9 6TM5
GO Terms Enriched among Interactors		Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity TOR Signaling Regulation Of Axon Extension Insulin Secretion Involved In Cellular Response To Glucose Stimulus Protein Kinase Activity Spectrin Binding Cytoskeleton Kinase Activity Regulation Of Axonogenesis Centrosome Ciliary Basal Body Regulation Of Postsynapse Organization Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Axon Cell Projection Organization Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Neuron Projection Organization Peptidyl-serine Phosphorylation Regulation Of Long-term Synaptic Potentiation Regulation Of Microtubule Anchoring At Centrosome Regulation Of Neuron Projection Development Negative Regulation Of Centriole-centriole Cohesion Positive Regulation Of Axon Extension Virus-like Capsid Insulin Secretion Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Cell Projection Maintenance Of Protein Location Maintenance Of Protein Location In Cell Maintenance Of Protein Location In Plasma Membrane Regulation Of Anatomical Structure Morphogenesis Plasma Membrane Bounded Cell Projection Organization Regulation Of Dendrite Morphogenesis Positive Regulation Of Cell-matrix Adhesion Superior Temporal Gyrus Development Modulation Of Chemical Synaptic Transmission Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Transport Vesicle Membrane HSP90-CDC37 Chaperone Complex Negative Regulation Of Embryonic Development Organelle Organization Positive Regulation Of Cell Communication By Electrical Coupling Cell Projection Morphogenesis Cytoskeleton Organization Regulation Of Biological Quality Neuron Projection Morphogenesis Synapse	Centrosome Regulation Of Organelle Organization Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Signaling Ciliary Basal Body Positive Regulation Of Microtubule Nucleation Regulation Of Cell Cycle Process Regulation Of Cellular Component Organization Ubiquitin Ligase Activator Activity Positive Regulation Of Organelle Organization Intracellular Signal Transduction Organelle Organization Positive Regulation Of Cellular Component Organization Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Checkpoint Regulation Of Microtubule Nucleation Neuron Cellular Homeostasis Regulation Of Centriole-centriole Cohesion Neuronal Cell Body Axon Initial Segment Regulation Of Nuclear Division Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Meiotic Cell Cycle Phase Transition Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Spindle Pole Regulation Of Cell Cycle Acinar Cell Differentiation Synapse Organization Chromosome, Centromeric Region Kinetochore Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Microtubule Polymerization Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Hematopoietic Or Lymphoid Organ Development Cell Division Regulation Of Protein Ubiquitination Regulation Of Developmental Growth Trachea Formation PTW/PP1 Phosphatase Complex Negative Regulation Of Mitotic Nuclear Division Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Cytoskeleton Cytosol Regulation Of Circadian Rhythm