SPTBN4 and PTPRN2

Number of citations: 84 (PubMedID 11086001)
Data Source: HPRD (two hybrid, in vivo)

		SPTBN4	PTPRN2
Name		spectrin beta, non-erythrocytic 4	protein tyrosine phosphatase receptor type N2
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Adherens Junction Cell Cortex Spectrin Intercalated Disc Membrane Nuclear Matrix PML Body Cell Junction Axon Cortical Actin Cytoskeleton Node Of Ranvier Paranode Region Of Axon Cell Projection Neuronal Cell Body Axon Initial Segment Axon Hillock Juxtaparanode Region Of Axon Extracellular Exosome Cell Body Fiber	Plasma Membrane Membrane Secretory Granule Transport Vesicle Membrane Secretory Granule Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Receptor Complex Synapse Ficolin-1-rich Granule Membrane
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Phosphatase Binding Ankyrin Binding Spectrin Binding Actin Filament Binding Cytoskeletal Protein-membrane Anchor Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Hydrolase Activity
	Biological Process	Regulation Of Sodium Ion Transport Axonogenesis Neuromuscular Junction Development Sensory Perception Of Sound Adult Walking Behavior Intracellular Protein Localization Fertilization Negative Regulation Of Heart Rate Vesicle-mediated Transport Transmission Of Nerve Impulse Central Nervous System Projection Neuron Axonogenesis Actin Cytoskeleton Organization Adult Behavior Positive Regulation Of Multicellular Organism Growth Clustering Of Voltage-gated Sodium Channels Neuromuscular Process Actin Filament Capping Cardiac Conduction Protein-containing Complex Assembly Protein Localization To Plasma Membrane	Protein Dephosphorylation Lipid Metabolic Process Neurotransmitter Secretion Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Secretion
Pathways		NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport	Neutrophil degranulation
GWAS		Antibody level in response to infection ( 25758998 ) Carotid intima media thickness (mean) ( 31801372 ) Hemoglobin levels ( 32327693 ) Pulse pressure ( 30578418 )	Bipolar disorder and schizophrenia ( 21057379 ) Breast cancer in childhood cancer survivors ( 29059430 ) Breast cancer in childhood cancer survivors treated with more than 10 gray radiotherapy ( 29059430 ) Calcium levels ( 25972035 ) Carotid plaque burden ( 28282560 ) Chronic rhinosinusitis ( 33393196 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444 ) Diastolic blood pressure ( 27841878 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821 ) Hearing loss in noise exposure ( 33242228 ) Inflammatory skin disease ( 25574825 ) Intelligence (MTAG) ( 29326435 ) Myopia (pathological) ( 23049088 ) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377 ) Obesity-related traits ( 23251661 ) Plasma anti-thyroid peroxidase levels ( 29678681 ) Refractive error ( 32231278 ) Response to amphetamines ( 22952603 ) Retinal detachment or retinal break ( 31816047 ) Serum metabolite concentrations in chronic kidney disease ( 29545352 ) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485 ) Triacylglyceride levels ( 31551469 )
Novel Interactors		None recorded	1 novel interactors: RHEB
Interacting Genes		18 interacting genes: ANK3 ARC CDC37 CDKL5 CELSR3 CENPU CFAP298 CLK1 DISC1 GADD45A GSK3B MORC3 NEK2 PFDN1 PTPRN PTPRN2 RPS6KA6 SPTAN1	3 interacting genes: CKAP5 SPTBN4 UBQLN4
Entrez ID		57731	5799
HPRD ID		09372	03413
Ensembl ID		ENSG00000160460	ENSG00000155093
Uniprot IDs		Q9H254	E7EM83 I6L9F8 Q92932
PDB IDs		Not available	2QEP 4HTI 4HTJ
GO Terms Enriched among Interactors		Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity TOR Signaling Regulation Of Axon Extension Insulin Secretion Involved In Cellular Response To Glucose Stimulus Protein Kinase Activity Spectrin Binding Cytoskeleton Kinase Activity Regulation Of Axonogenesis Centrosome Ciliary Basal Body Regulation Of Postsynapse Organization Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Axon Cell Projection Organization Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Neuron Projection Organization Peptidyl-serine Phosphorylation Regulation Of Long-term Synaptic Potentiation Regulation Of Microtubule Anchoring At Centrosome Regulation Of Neuron Projection Development Negative Regulation Of Centriole-centriole Cohesion Positive Regulation Of Axon Extension Virus-like Capsid Insulin Secretion Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Cell Projection Maintenance Of Protein Location Maintenance Of Protein Location In Cell Maintenance Of Protein Location In Plasma Membrane Regulation Of Anatomical Structure Morphogenesis Plasma Membrane Bounded Cell Projection Organization Regulation Of Dendrite Morphogenesis Positive Regulation Of Cell-matrix Adhesion Superior Temporal Gyrus Development Modulation Of Chemical Synaptic Transmission Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Transport Vesicle Membrane HSP90-CDC37 Chaperone Complex Negative Regulation Of Embryonic Development Organelle Organization Positive Regulation Of Cell Communication By Electrical Coupling Cell Projection Morphogenesis Cytoskeleton Organization Regulation Of Biological Quality Neuron Projection Morphogenesis Synapse	Negative Regulation Of Autophagy Microtubule Plus End Polymerase Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein-containing Complex Disassembly Regulation Of Macroautophagy Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Negative Regulation Of Autophagosome Maturation Nuclear Proteasome Complex Cytoskeletal Protein-membrane Anchor Activity Regulation Of Organelle Organization Cytosolic Proteasome Complex Clustering Of Voltage-gated Sodium Channels Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Microtubule Nucleation Axon Hillock Cell Body Fiber Paranode Region Of Axon Spectrin Negative Regulation Of Catabolic Process Regulation Of Autophagy Regulation Of Supramolecular Fiber Organization K48-linked Polyubiquitin Modification-dependent Protein Binding Juxtaparanode Region Of Axon Neuronal Ion Channel Clustering Negative Regulation Of Heart Rate Regulation Of Protein-containing Complex Assembly Regulation Of Autophagosome Maturation Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Microtubule Nucleation Centrosome Duplication Microtubule Polymerization Microtubule Plus-end Binding Microtubule Depolymerization Node Of Ranvier Ankyrin Binding Negative Regulation Of Heart Contraction Microtubule Plus-end Regulation Of Cytoskeleton Organization Transmission Of Nerve Impulse Negative Regulation Of Blood Circulation Axon Initial Segment