DISC1 and CDC37

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DISC1	CDC37
Description		DISC1 scaffold protein	cell division cycle 37, HSP90 cochaperone
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Kinesin Complex Microtubule Synaptic Vesicle Postsynaptic Density Dynein Complex Axon Ciliary Basal Body Cell Body Intermediate Filament Cytoskeleton Synapse Perinuclear Region Of Cytoplasm Central Region Of Growth Cone Ciliary Base Presynapse Glutamatergic Synapse GABA-ergic Synapse	Cytoplasm Cytosol Extracellular Exosome Protein Folding Chaperone Complex HSP90-CDC37 Chaperone Complex
	Molecular Function	Protein Binding Kinesin Binding Identical Protein Binding Protein-containing Complex Binding Molecular Adaptor Activity	Protein Binding Protein Kinase Regulator Activity Kinase Binding Protein Kinase Binding Heat Shock Protein Binding Unfolded Protein Binding Protein-folding Chaperone Binding Hsp90 Protein Binding Scaffold Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Neuron Migration Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Neuroblast Proliferation Ubiquitin-dependent Protein Catabolic Process Nervous System Development Intracellular Protein Localization Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Cerebral Cortex Radially Oriented Cell Migration Cell Proliferation In Forebrain Pyramidal Neuron Migration To Cerebral Cortex Positive Regulation Of Wnt Signaling Pathway TOR Signaling Positive Regulation Of Axon Extension Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Mitochondrial Calcium Ion Homeostasis Response To Electrical Stimulus Regulation Of Synaptic Transmission, Glutamatergic Canonical Wnt Signaling Pathway Cilium Assembly Regulation Of Dendritic Spine Development Neuron Cellular Homeostasis Protein Localization To Centrosome Regulation Of Synapse Maturation Regulation Of Postsynapse Organization Non-motile Cilium Assembly Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Folding Protein Targeting Post-transcriptional Regulation Of Gene Expression Protein Stabilization Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type 2 Mitophagy
Pathways			Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Constitutive Signaling by EGFRvIII Regulation of necroptotic cell death Downregulation of ERBB2 signaling RHOBTB2 GTPase cycle Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS		Alzheimer's disease ( 19118814) Amyotrophic lateral sclerosis ( 19451621) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arterial stiffness index ( 31235810) Bell's palsy ( 33602968) Chronic periodontitis (mean interproximal clinical attachment level) ( 27601451) Metabolite levels ( 23823483) Neuranatomic and neurocognitive phenotypes ( 21483430) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to antidepressants (symptom improvement) ( 29160301) Response to antineoplastic agents ( 21659360) Response to statin therapy ( 20339536) Serum docosahexaenoic fatty acid concentration in metabolic syndrome ( 31991592) Waist circumference ( 28552196)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) LDL cholesterol levels in HIV infection ( 33109212) Multiple sclerosis ( 21833088) White blood cell count ( 32888494)
Interacting Genes		183 interacting genes: ABI2 ACTG1 ACTN2 ADO AGTPBP1 AIMP2 AIRIM AKAP6 AMOT AP1M1 ARIH2 ARMC7 ATF4 ATF5 ATF7IP BAG2 BFSP2 BICD1 BRD1 C8orf33 CARD9 CATSPERT CCDC102B CCDC13 CCDC136 CCDC141 CCDC197 CCDC24 CCDC57 CCDC88A CCDC92 CCHCR1 CDC23 CDC37 CDC5L CDK5RAP3 CDKL3 CEP126 CEP57L1 CEP63 CFAP206 CIT CLU COL4A1 CRMP1 CTNNA3 CWF19L2 DCTN1 DCTN2 DDX6 DMD DNAJC7 DPYSL2 DPYSL3 DRC4 DST DYNC1H1 EEF2 EIF3H EIF4A3 EMSY EXOC1 EXOC4 EXOC7 FBXO34 FBXO41 FBXW7 FEZ1 FLACC1 FRYL GABARAPL1 GAS2L2 GCC1 GEM GNB1 GNG13 GNPTAB GPANK1 GPRASP2 GRIPAP1 GSK3B HERC2P2 HNRNPC IFT74 IMMT ITSN1 KALRN KANSL1 KCNQ5 KIF3A KIF3C KIF9 KIFAP3 KIFC3 LENG1 MACF1 MAP1A MEMO1 MLLT10 MNS1 MORF4L2 MPPED1 MVP MYH7 MYT1L NCK2 NDE1 NDEL1 NECAB1 NEFM NME7 NSRP1 NUP160 OLFM1 PCNT PCNX4 PGK1 PHF1 PIBF1 PIK3R3 PKN1 POLR3C PPFIA3 PPM1E PPP4R1 PPP5C PSPC1 QARS1 RABGAP1 RAD21 RANBP9 RASSF7 RBM41 RBSN RECK ROGDI RTRAF SH3BP5 SMARCD1 SMARCE1 SMC2 SMC3 SMC5 SMYD1 SNX6 SPARCL1 SPATC1L SPTBN4 SRGAP2 SRGAP3 STX11 STX18 SUFU SYBU SYNE1 TCAF1 TCEANC TFIP11 TIAM2 TRAF3IP1 TRAF4 TRIM29 TRIM68 TRIO TSGA10 TSPOAP1 TSR2 TTC23 TUBB TUBB2A UBASH3A UBASH3B USP2 UTRN XPNPEP1 YWHAE YWHAG YWHAQ YWHAZ ZNF124 ZNF197 ZNF365 ZNF76	182 interacting genes: A2M ACTB ACTG1 AKT1 AMOTL2 APOE APP AR BEND7 BLZF1 BTBD10 BTBD3 C19orf44 CAMK2A CAMK2B CAMK2G CARD10 CARD9 CAVIN1 CBY2 CC2D1A CCDC138 CCDC152 CCDC91 CCHCR1 CDC37L1 CDK2 CDK3 CDK4 CDK5 CDK6 CEP55 CEP70 CGGBP1 CHGA CHUK CKS1B CKS2 CRYM CSNK2A1 CSNK2A2 CT45A1 CTAG1A CTAG1B CUTC CYP2C9 DCTN1 DEAF1 DISC1 DRC4 ECSIT EIF2AK1 EIF2S1 ELAVL3 ENOX2 EXOSC1 FAM118A FAM9B FATE1 FBXL12 FBXW4 GABARAP GABARAPL1 GABARAPL2 GAS7 GCDH GCH1 GFAP GMCL1 GOLGA2 GOLGA6L9 GPRASP3 GRAMD2B GRIPAP1 HIVEP1 HOMER3 HSF2BP HSP90AA1 IFIT5 IKBKB IKBKE IKBKG IKZF3 IMMT JRK KATNBL1 KCTD13 KCTD9 KIFC3 KLHL2 KRT75 KRT76 LMNB2 LONP1 LOXL4 LUC7L2 LZTS1 MAD1L1 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K14 MAP3K3 MDFI MID1 MIPOL1 MRPL9 MTOR MZT2B NCOA5 NECAB1 NECAB2 NOS3 NR2C2 NRIP3 NT5C1A OGA OGT PAICS PDE9A PIBF1 PNMA2 POU6F2 PPHLN1 PPP5C PRAM1 PRDX2 PRKAR1B PRMT1 PRMT5 PRPH PRR20A PRR20B PRR20C PRR20D PRR20E PSMC6 PSME1 PTGES3 RABGEF1 RAD23A RAF1 REEP6 RNF32 ROPN1 RPS15A SAFB SEPTIN3 SNX5 SPTBN4 SQSTM1 SRRM4 SSNA1 STAMBPL1 STIP1 STK11 STX1A SYCE2 SYCP3 TBK1 TCF4 THAP1 THAP7 TNFAIP1 TNIP1 TRAF2 TRAF3 TRAF5 TRIM54 UBE2I USHBP1 WAC ZBED1 ZBTB26 ZBTB8A ZNF205 ZNF235 ZNF266 ZNF276 ZNF655 ZNF667 ZNF837
Entrez ID		27185	11140
HPRD ID		05553	05456
Ensembl ID		ENSG00000162946	ENSG00000105401
Uniprot IDs		C4P094 C4P096 C4P098 C4P0A4 C4P0A5 C4P0C4 C4P0C8 C4P0D0 C4P0D1 C4P0D2 C4P0D3 Q9NRI5	Q16543
PDB IDs		5V4B	1US7 2K5B 2N5X 2NCA 2W0G 5FWK 5FWL 5FWM 5FWP 5HPE 7Z37 7Z38 7ZR0 7ZR5 7ZR6 8GAE 8GFT 8U1L
Enriched GO Terms of Interacting Partners?		Cytoskeleton Centrosome Microtubule Cytoplasm Microtubule-based Process Protein Binding Microtubule Cytoskeleton Organization Organelle Organization Cytosol Cytoskeleton-dependent Intracellular Transport Cytoskeleton Organization Microtubule-based Movement Microtubule Binding Transport Along Microtubule Microtubule-based Transport Organelle Localization Axo-dendritic Transport Identical Protein Binding Axonal Transport Kinesin Complex Regulation Of Microtubule-based Process Regulation Of Organelle Organization Retrograde Axonal Transport Cell Projection Organization Cell Projection Assembly Cytoskeletal Anchor Activity Regulation Of Cellular Component Organization Developmental Process Cilium Axon Cytoplasm Cell Projection Tau Protein Binding Plasma Membrane Bounded Cell Projection Assembly Ciliary Basal Body Ciliary Tip Organelle Assembly Microtubule Cytoskeleton Organization Involved In Mitosis Centriole Structural Constituent Of Cytoskeleton Microtubule Nucleation Nervous System Development Dihydropyrimidinase Activity Cilium Organization Positive Regulation Of Protein Localization To Cilium Negative Regulation Of Protein Phosphorylation Negative Regulation Of Protein Metabolic Process Synapse Ubiquitin Protein Ligase Binding Plasma Membrane Bounded Cell Projection Organization Establishment Of Organelle Localization	Identical Protein Binding Cytosol Protein Binding Cytoplasm Cellular Response To Nitrogen Starvation Mitophagy Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Serine/threonine Kinase Activity Phosphatidylethanolamine Binding Autophagy Of Mitochondrion Protein Serine Kinase Activity Regulation Of Canonical NF-kappaB Signal Transduction Organelle Organization Macroautophagy Positive Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Positive Regulation Of Signal Transduction CD40 Receptor Complex Protein Kinase Activity Regulation Of Proteolysis Regulation Of Intracellular Signal Transduction Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Localization To Membrane Cyclin-dependent Protein Kinase Holoenzyme Complex IkappaB Kinase Complex Negative Regulation Of Translational Initiation Microtubule Binding Autophagy Regulation Of Protein Localization To Cell Periphery Regulation Of Signal Transduction Intracellular Protein Localization IkappaB Kinase Activity Regulation Of Signaling Regulation Of Cell Communication Serine/threonine Protein Kinase Complex Regulation Of Protein Catabolic Process Kinase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Synaptic Transmission Cellular Response To Nutrient Levels Cellular Response To Starvation Response To Starvation Toll-like Receptor 4 Signaling Pathway Regulation Of Protein Localization To Plasma Membrane Anoikis Positive Regulation Of TORC1 Signaling Tau Protein Binding Regulation Of Macroautophagy
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