SPTBN4 and SPTAN1

Number of citations of the paper that reports this interaction (PubMedID 17607528)
56

Data Source:
BioGRID (two hybrid)

		SPTBN4	SPTAN1
Description		spectrin beta, non-erythrocytic 4	spectrin alpha, non-erythrocytic 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Adherens Junction Cell Cortex Spectrin Intercalated Disc Membrane Nuclear Matrix PML Body Cell Junction Axon Cortical Actin Cytoskeleton Node Of Ranvier Paranode Region Of Axon Cell Projection Neuronal Cell Body Axon Initial Segment Axon Hillock Juxtaparanode Region Of Axon Extracellular Exosome Cell Body Fiber	Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin Microtubule Cytoskeleton Membrane Cell Junction Cortical Actin Cytoskeleton Specific Granule Lumen Cell Projection Extracellular Exosome Extracellular Vesicle Tertiary Granule Lumen
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Phosphatase Binding Ankyrin Binding Spectrin Binding Actin Filament Binding Cytoskeletal Protein-membrane Anchor Activity	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Calmodulin Binding Cadherin Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Regulation Of Sodium Ion Transport Axonogenesis Neuromuscular Junction Development Sensory Perception Of Sound Adult Walking Behavior Intracellular Protein Localization Fertilization Negative Regulation Of Heart Rate Vesicle-mediated Transport Transmission Of Nerve Impulse Central Nervous System Projection Neuron Axonogenesis Actin Cytoskeleton Organization Adult Behavior Positive Regulation Of Multicellular Organism Growth Clustering Of Voltage-gated Sodium Channels Neuromuscular Process Actin Filament Capping Cardiac Conduction Protein-containing Complex Assembly Protein Localization To Plasma Membrane	Actin Cytoskeleton Organization Actin Filament Capping
Pathways		NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport	Caspase-mediated cleavage of cytoskeletal proteins Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade Neutrophil degranulation COPI-mediated anterograde transport RHOU GTPase cycle RHOV GTPase cycle Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases			Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Antibody level in response to infection ( 25758998) Carotid intima media thickness (mean) ( 31801372) Hemoglobin levels ( 32327693) Pulse pressure ( 30578418)	Axial length ( 24144296) Body mass index ( 26426971)
Interacting Genes		18 interacting genes: ANK3 ARC CDC37 CDKL5 CELSR3 CENPU CFAP298 CLK1 DISC1 GADD45A GSK3B MORC3 NEK2 PFDN1 PTPRN PTPRN2 RPS6KA6 SPTAN1	60 interacting genes: ABI1 ABL1 ACP1 ACTA1 ACTB AKIP1 ANK1 CAPN1 CASP3 CASP7 CEP63 CREBBP CTNNA1 DDX24 DES EPB41 EPB41L2 EPB42 ERCC4 EVL EXOC1 FANCA FANCC GAP43 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2D ITSN1 KALRN KARS1 MAPK6 NEFL PCNT PDE4D PIN4 PLEC PLEKHA5 PRKCB PSMG1 PTEN PTOV1 SHANK1 SHANK3 SLC9A2 SOS1 SPTB SPTBN1 SPTBN4 SRC STAT1 SUMO2 SYN1 TAF1 TANC1 TES TSSC4 TTC3 ZNF333
Entrez ID		57731	6709
HPRD ID		09372	01684
Ensembl ID		ENSG00000160460	ENSG00000197694
Uniprot IDs		Q9H254	A0A0D9SF54 A0A0D9SFF6 A0A0D9SGF6 A0A384P5S9 A0A994J6W3 Q13813
PDB IDs			2FOT 3F31 3FB2 5FW9 5FWB 5FWC 6ZEH
Enriched GO Terms of Interacting Partners?		Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity TOR Signaling Regulation Of Axon Extension Insulin Secretion Involved In Cellular Response To Glucose Stimulus Protein Kinase Activity Spectrin Binding Cytoskeleton Kinase Activity Regulation Of Axonogenesis Centrosome Ciliary Basal Body Regulation Of Postsynapse Organization Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Axon Cell Projection Organization Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Neuron Projection Organization Peptidyl-serine Phosphorylation Regulation Of Long-term Synaptic Potentiation Regulation Of Microtubule Anchoring At Centrosome Regulation Of Neuron Projection Development Negative Regulation Of Centriole-centriole Cohesion Positive Regulation Of Axon Extension Virus-like Capsid Insulin Secretion Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Cell Projection Maintenance Of Protein Location Maintenance Of Protein Location In Cell Maintenance Of Protein Location In Plasma Membrane Regulation Of Anatomical Structure Morphogenesis Plasma Membrane Bounded Cell Projection Organization Regulation Of Dendrite Morphogenesis Positive Regulation Of Cell-matrix Adhesion Superior Temporal Gyrus Development Modulation Of Chemical Synaptic Transmission Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Transport Vesicle Membrane HSP90-CDC37 Chaperone Complex Negative Regulation Of Embryonic Development Organelle Organization Positive Regulation Of Cell Communication By Electrical Coupling Cell Projection Morphogenesis Cytoskeleton Organization Regulation Of Biological Quality Neuron Projection Morphogenesis Synapse	Postsynaptic Density Structural Constituent Of Cytoskeleton Cytoskeleton Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Spectrin Cytoplasm Ligand-gated Ion Channel Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Glutamate Receptor Signaling Pathway Cytosol Cytoskeletal Protein Binding NMDA Glutamate Receptor Activity Spectrin-associated Cytoskeleton NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Excitatory Chemical Synaptic Transmission Regulation Of System Process Glutamatergic Synapse Ligand-gated Monoatomic Ion Channel Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Synapse Neuromuscular Process Modulation Of Chemical Synaptic Transmission Regulation Of Nervous System Process Cytoskeleton Organization Neuron Projection Regulation Of Biological Quality Ankyrin Binding Learning Or Memory Cell Junction Plasma Membrane Dendritic Spine Cell Projection Organization Associative Learning Glutamate Binding Postsynaptic Membrane Cognition Regulation Of Neuronal Synaptic Plasticity Plasma Membrane Bounded Cell Projection Organization Spectrin Binding Cortical Cytoskeleton SH3 Domain Binding Regulation Of Membrane Potential Cell Surface Receptor Signaling Pathway Dendritic Spine Organization Actin Cytoskeleton Organization Cell Junction Organization Cellular Component Assembly Dendrite
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