SPTBN4

Name	spectrin beta, non-erythrocytic 4
Structure	No pdb structure
Interactors	18 interactors: ANK3 ARC CDC37 CDKL5 CELSR3 CENPU CFAP298 CLK1 DISC1 GADD45A GSK3B MORC3 NEK2 PFDN1 PTPRN PTPRN2 RPS6KA6 SPTAN1
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Adherens Junction Cell Cortex Spectrin Intercalated Disc Membrane Nuclear Matrix PML Body Cell Junction Axon Cortical Actin Cytoskeleton Node Of Ranvier Paranode Region Of Axon Cell Projection Neuronal Cell Body Axon Initial Segment Axon Hillock Juxtaparanode Region Of Axon Extracellular Exosome Cell Body Fiber
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Phosphatase Binding Ankyrin Binding Spectrin Binding Actin Filament Binding Cytoskeletal Protein-membrane Anchor Activity
	Biological Process	Regulation Of Sodium Ion Transport Axonogenesis Neuromuscular Junction Development Sensory Perception Of Sound Adult Walking Behavior Intracellular Protein Localization Fertilization Negative Regulation Of Heart Rate Vesicle-mediated Transport Transmission Of Nerve Impulse Central Nervous System Projection Neuron Axonogenesis Actin Cytoskeleton Organization Adult Behavior Positive Regulation Of Multicellular Organism Growth Clustering Of Voltage-gated Sodium Channels Neuromuscular Process Actin Filament Capping Cardiac Conduction Protein-containing Complex Assembly Protein Localization To Plasma Membrane
Pathways	NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
GWAS	Antibody level in response to infection ( 25758998 ) Carotid intima media thickness (mean) ( 31801372 ) Hemoglobin levels ( 32327693 ) Pulse pressure ( 30578418 )
Entrez ID	57731
HPRD ID	09372
Ensembl ID	ENSG00000160460
Uniprot IDs	Q9H254
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity TOR Signaling Regulation Of Axon Extension Insulin Secretion Involved In Cellular Response To Glucose Stimulus Protein Kinase Activity Spectrin Binding Cytoskeleton Kinase Activity Regulation Of Axonogenesis Centrosome Ciliary Basal Body Regulation Of Postsynapse Organization Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Axon Cell Projection Organization Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Neuron Projection Organization Peptidyl-serine Phosphorylation Regulation Of Long-term Synaptic Potentiation Regulation Of Microtubule Anchoring At Centrosome Regulation Of Neuron Projection Development Negative Regulation Of Centriole-centriole Cohesion Positive Regulation Of Axon Extension Virus-like Capsid Insulin Secretion Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Cell Projection Maintenance Of Protein Location Maintenance Of Protein Location In Cell Maintenance Of Protein Location In Plasma Membrane Regulation Of Anatomical Structure Morphogenesis Plasma Membrane Bounded Cell Projection Organization Regulation Of Dendrite Morphogenesis Positive Regulation Of Cell-matrix Adhesion Superior Temporal Gyrus Development Modulation Of Chemical Synaptic Transmission Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Transport Vesicle Membrane HSP90-CDC37 Chaperone Complex Negative Regulation Of Embryonic Development Organelle Organization Positive Regulation Of Cell Communication By Electrical Coupling Cell Projection Morphogenesis Cytoskeleton Organization Regulation Of Biological Quality Neuron Projection Morphogenesis Synapse