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DISC1 and PSPC1
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
DISC1
PSPC1
Description
DISC1 scaffold protein
paraspeckle component 1
Image
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Centrosome
Microtubule Organizing Center
Cytosol
Cytoskeleton
Kinesin Complex
Microtubule
Synaptic Vesicle
Postsynaptic Density
Dynein Complex
Axon
Ciliary Basal Body
Cell Body
Intermediate Filament Cytoskeleton
Synapse
Perinuclear Region Of Cytoplasm
Central Region Of Growth Cone
Ciliary Base
Presynapse
Glutamatergic Synapse
GABA-ergic Synapse
Fibrillar Center
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Nuclear Matrix
Nuclear Speck
Paraspeckles
Molecular Function
Protein Binding
Kinesin Binding
Identical Protein Binding
Protein-containing Complex Binding
Molecular Adaptor Activity
Nucleic Acid Binding
RNA Binding
Protein Binding
Biological Process
Microtubule Cytoskeleton Organization
Neuron Migration
Positive Regulation Of Cell-matrix Adhesion
Positive Regulation Of Neuroblast Proliferation
Ubiquitin-dependent Protein Catabolic Process
Nervous System Development
Intracellular Protein Localization
Regulation Of Neuron Projection Development
Positive Regulation Of Neuron Projection Development
Wnt Signaling Pathway
Cerebral Cortex Radially Oriented Cell Migration
Cell Proliferation In Forebrain
Pyramidal Neuron Migration To Cerebral Cortex
Positive Regulation Of Wnt Signaling Pathway
TOR Signaling
Positive Regulation Of Axon Extension
Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain
Mitochondrial Calcium Ion Homeostasis
Response To Electrical Stimulus
Regulation Of Synaptic Transmission, Glutamatergic
Canonical Wnt Signaling Pathway
Cilium Assembly
Regulation Of Dendritic Spine Development
Neuron Cellular Homeostasis
Protein Localization To Centrosome
Regulation Of Synapse Maturation
Regulation Of Postsynapse Organization
Non-motile Cilium Assembly
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Activation Of Innate Immune Response
Immune System Process
Regulation Of DNA-templated Transcription
Regulation Of Circadian Rhythm
Innate Immune Response
Negative Regulation Of DNA-templated Transcription
Rhythmic Process
Membraneless Organelle Assembly
Pathways
Drugs
Diseases
GWAS
Alzheimer's disease (
19118814
)
Amyotrophic lateral sclerosis (
19451621
)
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Arterial stiffness index (
31235810
)
Bell's palsy (
33602968
)
Chronic periodontitis (mean interproximal clinical attachment level) (
27601451
)
Metabolite levels (
23823483
)
Neuranatomic and neurocognitive phenotypes (
21483430
)
Pelvic organ prolapse (moderate/severe) (
26545240
)
Response to antidepressants (symptom improvement) (
29160301
)
Response to antineoplastic agents (
21659360
)
Response to statin therapy (
20339536
)
Serum docosahexaenoic fatty acid concentration in metabolic syndrome (
31991592
)
Waist circumference (
28552196
)
Waist circumference adjusted for body mass index (
28552196
)
Interacting Genes
183 interacting genes:
ABI2
ACTG1
ACTN2
ADO
AGTPBP1
AIMP2
AIRIM
AKAP6
AMOT
AP1M1
ARIH2
ARMC7
ATF4
ATF5
ATF7IP
BAG2
BFSP2
BICD1
BRD1
C8orf33
CARD9
CATSPERT
CCDC102B
CCDC13
CCDC136
CCDC141
CCDC197
CCDC24
CCDC57
CCDC88A
CCDC92
CCHCR1
CDC23
CDC37
CDC5L
CDK5RAP3
CDKL3
CEP126
CEP57L1
CEP63
CFAP206
CIT
CLU
COL4A1
CRMP1
CTNNA3
CWF19L2
DCTN1
DCTN2
DDX6
DMD
DNAJC7
DPYSL2
DPYSL3
DRC4
DST
DYNC1H1
EEF2
EIF3H
EIF4A3
EMSY
EXOC1
EXOC4
EXOC7
FBXO34
FBXO41
FBXW7
FEZ1
FLACC1
FRYL
GABARAPL1
GAS2L2
GCC1
GEM
GNB1
GNG13
GNPTAB
GPANK1
GPRASP2
GRIPAP1
GSK3B
HERC2P2
HNRNPC
IFT74
IMMT
ITSN1
KALRN
KANSL1
KCNQ5
KIF3A
KIF3C
KIF9
KIFAP3
KIFC3
LENG1
MACF1
MAP1A
MEMO1
MLLT10
MNS1
MORF4L2
MPPED1
MVP
MYH7
MYT1L
NCK2
NDE1
NDEL1
NECAB1
NEFM
NME7
NSRP1
NUP160
OLFM1
PCNT
PCNX4
PGK1
PHF1
PIBF1
PIK3R3
PKN1
POLR3C
PPFIA3
PPM1E
PPP4R1
PPP5C
PSPC1
QARS1
RABGAP1
RAD21
RANBP9
RASSF7
RBM41
RBSN
RECK
ROGDI
RTRAF
SH3BP5
SMARCD1
SMARCE1
SMC2
SMC3
SMC5
SMYD1
SNX6
SPARCL1
SPATC1L
SPTBN4
SRGAP2
SRGAP3
STX11
STX18
SUFU
SYBU
SYNE1
TCAF1
TCEANC
TFIP11
TIAM2
TRAF3IP1
TRAF4
TRIM29
TRIM68
TRIO
TSGA10
TSPOAP1
TSR2
TTC23
TUBB
TUBB2A
UBASH3A
UBASH3B
USP2
UTRN
XPNPEP1
YWHAE
YWHAG
YWHAQ
YWHAZ
ZNF124
ZNF197
ZNF365
ZNF76
16 interacting genes:
CEBPA
DANCR
DISC1
ESR1
KRT31
KRTAP13-1
LRIF1
LZTS1
NEIL3
NONO
NUDT21
SFPQ
TCERG1
WBP4
ZRANB1
ZSCAN5B
Entrez ID
27185
55269
HPRD ID
05553
10172
Ensembl ID
ENSG00000162946
ENSG00000121390
Uniprot IDs
C4P094
C4P096
C4P098
C4P0A4
C4P0A5
C4P0C4
C4P0C8
C4P0D0
C4P0D1
C4P0D2
C4P0D3
Q9NRI5
Q8WXF1
PDB IDs
5V4B
3SDE
5IFN
5WPA
Enriched GO Terms of Interacting Partners
?
Cytoskeleton
Centrosome
Microtubule
Cytoplasm
Microtubule-based Process
Protein Binding
Microtubule Cytoskeleton Organization
Organelle Organization
Cytosol
Cytoskeleton-dependent Intracellular Transport
Cytoskeleton Organization
Microtubule-based Movement
Microtubule Binding
Transport Along Microtubule
Microtubule-based Transport
Organelle Localization
Axo-dendritic Transport
Identical Protein Binding
Axonal Transport
Kinesin Complex
Regulation Of Microtubule-based Process
Regulation Of Organelle Organization
Retrograde Axonal Transport
Cell Projection Organization
Cell Projection Assembly
Cytoskeletal Anchor Activity
Regulation Of Cellular Component Organization
Developmental Process
Cilium
Axon Cytoplasm
Cell Projection
Tau Protein Binding
Plasma Membrane Bounded Cell Projection Assembly
Ciliary Basal Body
Ciliary Tip
Organelle Assembly
Microtubule Cytoskeleton Organization Involved In Mitosis
Centriole
Structural Constituent Of Cytoskeleton
Microtubule Nucleation
Nervous System Development
Dihydropyrimidinase Activity
Cilium Organization
Positive Regulation Of Protein Localization To Cilium
Negative Regulation Of Protein Phosphorylation
Negative Regulation Of Protein Metabolic Process
Synapse
Ubiquitin Protein Ligase Binding
Plasma Membrane Bounded Cell Projection Organization
Establishment Of Organelle Localization
Paraspeckles
Nuclear Matrix
MRNA Processing
Chromatin Binding
Histone Deacetylase Binding
RNA Metabolic Process
RNA Polymerase II Transcription Regulator Complex
Nucleic Acid Metabolic Process
MRNA Metabolic Process
RNA Splicing
Nuclear Speck
Nucleoplasm
RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding
RNA Processing
Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Pro-B Cell Differentiation
MCM Complex Binding
Nucleobase-containing Compound Metabolic Process
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