DISC1 and DST

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		DISC1	DST
Gene Name		disrupted in schizophrenia 1	dystonin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Centrosome Microtubule Postsynaptic Density Cell Junction Ciliary Basal Body Postsynaptic Membrane	Basement Membrane Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Membrane Cytosol Intermediate Filament Focal Adhesion Cell Cortex Basal Plasma Membrane Actin Cytoskeleton Microtubule Cytoskeleton Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Z Disc Hemidesmosome Axon Cell Leading Edge H Zone Microtubule Plus-end Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Protein C-terminus Binding Protein Homodimerization Activity Microtubule Plus-end Binding
	Biological Process	Microtubule Cytoskeleton Organization Neuron Migration Positive Regulation Of Neuroblast Proliferation Regulation Of Neuron Projection Development Cerebral Cortex Radially Oriented Cell Migration Cell Proliferation In Forebrain Positive Regulation Of Wnt Signaling Pathway TOR Signaling Cellular Protein Localization Mitochondrial Calcium Ion Homeostasis Canonical Wnt Signaling Pathway Regulation Of Synapse Maturation Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Microtubule Cytoskeleton Organization Cytoskeleton Organization Cell Cycle Arrest Cell Adhesion Integrin-mediated Signaling Pathway Response To Wounding Maintenance Of Cell Polarity Extracellular Matrix Organization Hemidesmosome Assembly Intermediate Filament Cytoskeleton Organization Cell Motility
Pathways			Cell junction organization Type I hemidesmosome assembly
Drugs
Diseases
GWAS		Alzheimer's disease ( 19118814) Amyotrophic lateral sclerosis ( 19451621) Neuranatomic and neurocognitive phenotypes ( 21483430) Response to antineoplastic agents ( 21659360) Response to statin therapy ( 20339536)
Protein-Protein Interactions		113 interactors: ACTG1 ACTN2 AGTPBP1 AKAP6 AKAP9 ARIH2 ATF4 ATF5 ATF7IP BICD1 BZRAP1 C14orf166 CCDC136 CCDC141 CCDC24 CCDC88A CDC5L CDK5RAP3 CEP170 CEP57L1 CEP63 CIT CLU COL4A1 DCTN1 DCTN2 DMD DNAJC7 DPYSL2 DPYSL3 DST DYNC1H1 EEF2 EIF3H EXOC1 EXOC4 EXOC7 FBXO41 FEZ1 FRYL GNB1 GNPTAB GPRASP2 HERC2P2 IFT20 IMMT ITSN1 KALRN KANSL1 KCNQ5 KIAA1377 KIF3A KIF3C KIFAP3 MACF1 MAP1A MATR3 MEMO1 MLLT10 MPPED1 MVP MYO1A MYT1L NDE1 NDEL1 NEFM NUP160 OLFM1 PAFAH1B1 PCNT PCNXL4 PDE4B PGK1 PPM1E PPP4R1 PPP5C RABGAP1 RAD21 RANBP9 RASSF7 RBSN ROGDI SH3BP5 SMARCE1 SMC2 SMC3 SNX6 SPARCL1 SPTAN1 SPTBN1 SPTBN4 SRGAP2 SRGAP3 STX18 SYBU SYNE1 TFIP11 TIAM2 TNIK TNKS TRAF3IP1 TRIO TUBB TUBB2A UTRN XPNPEP1 XRN2 YWHAE YWHAG YWHAQ YWHAZ ZNF197 ZNF365	26 interactors: APC CALM1 CDC5L CELSR3 CEP63 COL17A1 DCTN1 DISC1 DTNBP1 ERBB2IP EXOC1 ITGB4 ITSN2 KIAA0368 KIAA1549 KRT14 KRT5 MAPK6 NFYC PAK2 PRKAB2 PRKD2 SH3BP5 SMAD9 TNIK TRAF3IP1
Entrez ID		27185	667
HPRD ID		05553	00222
Ensembl ID		ENSG00000162946	ENSG00000151914
Uniprot IDs		C4P094 C4P096 C4P098 C4P0A4 C4P0A5 C4P0C4 C4P0C8 C4P0D0 C4P0D1 C4P0D2 C4P0D3 Q9NRI5	B4DGY0 B4DSS9 Q03001 Q6P0N6
PDB IDs			3GJO
Enriched GO Terms of Interacting Partners?		Organelle Organization Movement Of Cell Or Subcellular Component Cellular Localization Microtubule-based Process Nervous System Development Establishment Of Localization In Cell Neurogenesis G2/M Transition Of Mitotic Cell Cycle Generation Of Neurons Microtubule Cytoskeleton Organization Cytoskeleton-dependent Intracellular Transport Mitotic Cell Cycle Process Cellular Component Assembly Cell Projection Organization Mitotic Cell Cycle Microtubule-based Transport Cell Cycle Process Organelle Localization Cytoskeleton Organization Cell Cycle Cell Projection Morphogenesis Cell Part Morphogenesis Anatomical Structure Development System Development Membrane Organization Cell Differentiation Cell Morphogenesis Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Organelle Transport Along Microtubule Developmental Process Protein Localization Microtubule-based Movement Axonogenesis Mitotic Nuclear Division Locomotion Establishment Of Organelle Localization Axon Guidance Vesicle Localization Axon Development Neuron Development Cellular Process Regulation Of Cellular Component Organization Multicellular Organismal Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Neurogenesis Cell Projection Assembly Neuron Differentiation Intracellular Transport Spindle Organization	Hemidesmosome Assembly Cell-substrate Junction Assembly Cell Junction Assembly Signaling Organelle Organization Cell Communication Signal Transduction Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Intracellular Signal Transduction Regulation Of Kinase Activity Anatomical Structure Development Regulation Of Phosphorylation Cell Cycle Nervous System Development Developmental Process Cellular Component Assembly Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Epithelium Development Regulation Of Cellular Protein Metabolic Process Microtubule-based Process Cytoskeleton Organization Response To Stimulus Cell Projection Organization Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Epidermis Development Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Cell Projection Assembly Tissue Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Negative Regulation Of Protein Phosphorylation Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport System Development Regulation Of Catalytic Activity Cellular Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cell Adhesion Regulation Of Signal Transduction
Tagcloud ?		accelerate aggregated allosteric amplify appropriated assemblies assembly biochemically capsid catalytically collections commonality conceptualized continuum crowded exploit governed labile machines multimers multiprotein pathologically prions replicating replicative reprogrammed reset suited transmissibility	125i alanine amines analogous asked attach attached attaches attempted b2 bradykinin bromide covalently cyanogen disuccinimidyl epsilon exchanged homobifunctional immunoidentification k174a labeling linker lys172 lys174 reacts reagent tartarate tyr8 worked
Tagcloud (Difference) ?		accelerate aggregated allosteric amplify appropriated assemblies assembly biochemically capsid catalytically collections commonality conceptualized continuum crowded exploit governed labile machines multimers multiprotein pathologically prions replicating replicative reprogrammed reset suited transmissibility	125i alanine amines analogous asked attach attached attaches attempted b2 bradykinin bromide covalently cyanogen disuccinimidyl epsilon exchanged homobifunctional immunoidentification k174a labeling linker lys172 lys174 reacts reagent tartarate tyr8 worked
Tagcloud (Intersection) ?