DISC1 and MYT1L

Number of citations of the paper that reports this interaction (PubMedID 17043677)
0

Data Source:
BioGRID (two hybrid)

		DISC1	MYT1L
Description		DISC1 scaffold protein	myelin transcription factor 1 like
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Kinesin Complex Microtubule Synaptic Vesicle Postsynaptic Density Dynein Complex Axon Ciliary Basal Body Cell Body Intermediate Filament Cytoskeleton Synapse Perinuclear Region Of Cytoplasm Central Region Of Growth Cone Ciliary Base Presynapse Glutamatergic Synapse GABA-ergic Synapse	Chromatin Nucleus Chromosome
	Molecular Function	Protein Binding Kinesin Binding Identical Protein Binding Protein-containing Complex Binding Molecular Adaptor Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Zinc Ion Binding Retinoic Acid-responsive Element Binding Metal Ion Binding Cobalt Ion Binding Metal Ion Sequestering Activity
	Biological Process	Microtubule Cytoskeleton Organization Neuron Migration Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Neuroblast Proliferation Ubiquitin-dependent Protein Catabolic Process Nervous System Development Intracellular Protein Localization Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Cerebral Cortex Radially Oriented Cell Migration Cell Proliferation In Forebrain Pyramidal Neuron Migration To Cerebral Cortex Positive Regulation Of Wnt Signaling Pathway TOR Signaling Positive Regulation Of Axon Extension Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Mitochondrial Calcium Ion Homeostasis Response To Electrical Stimulus Regulation Of Synaptic Transmission, Glutamatergic Canonical Wnt Signaling Pathway Cilium Assembly Regulation Of Dendritic Spine Development Neuron Cellular Homeostasis Protein Localization To Centrosome Regulation Of Synapse Maturation Regulation Of Postsynapse Organization Non-motile Cilium Assembly Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Cell Differentiation Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment Neuron Fate Specification Neuron Development
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease ( 19118814) Amyotrophic lateral sclerosis ( 19451621) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arterial stiffness index ( 31235810) Bell's palsy ( 33602968) Chronic periodontitis (mean interproximal clinical attachment level) ( 27601451) Metabolite levels ( 23823483) Neuranatomic and neurocognitive phenotypes ( 21483430) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to antidepressants (symptom improvement) ( 29160301) Response to antineoplastic agents ( 21659360) Response to statin therapy ( 20339536) Serum docosahexaenoic fatty acid concentration in metabolic syndrome ( 31991592) Waist circumference ( 28552196)	Adventurousness ( 30643258) Attention deficit hyperactivity disorder ( 18839057) Caudate nucleus volume ( 31530798) Cognitive decline rate in late mild cognitive impairment ( 26252872) Diabetic retinopathy ( 21441570) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Glucose homeostasis traits ( 25524916) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota (functional units) ( 27694959) Impulsivity ( 30718321) Impulsivity (motor) ( 30718321) Impulsivity (non-planning) ( 30718321) Inflammatory skin disease ( 25574825) Mitochondrial DNA copy number (white blood cells) ( 30704525) Moderate-to-late spontaneous preterm birth ( 31194736) Response to selective serotonin reuptake inhibitors and depression ( 27622933) Systemic sclerosis ( 30247649) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Type 2 diabetes (age of onset) ( 28060188) Vitamin B levels in ischemic stroke ( 25147783)
Interacting Genes		183 interacting genes: ABI2 ACTG1 ACTN2 ADO AGTPBP1 AIMP2 AIRIM AKAP6 AMOT AP1M1 ARIH2 ARMC7 ATF4 ATF5 ATF7IP BAG2 BFSP2 BICD1 BRD1 C8orf33 CARD9 CATSPERT CCDC102B CCDC13 CCDC136 CCDC141 CCDC197 CCDC24 CCDC57 CCDC88A CCDC92 CCHCR1 CDC23 CDC37 CDC5L CDK5RAP3 CDKL3 CEP126 CEP57L1 CEP63 CFAP206 CIT CLU COL4A1 CRMP1 CTNNA3 CWF19L2 DCTN1 DCTN2 DDX6 DMD DNAJC7 DPYSL2 DPYSL3 DRC4 DST DYNC1H1 EEF2 EIF3H EIF4A3 EMSY EXOC1 EXOC4 EXOC7 FBXO34 FBXO41 FBXW7 FEZ1 FLACC1 FRYL GABARAPL1 GAS2L2 GCC1 GEM GNB1 GNG13 GNPTAB GPANK1 GPRASP2 GRIPAP1 GSK3B HERC2P2 HNRNPC IFT74 IMMT ITSN1 KALRN KANSL1 KCNQ5 KIF3A KIF3C KIF9 KIFAP3 KIFC3 LENG1 MACF1 MAP1A MEMO1 MLLT10 MNS1 MORF4L2 MPPED1 MVP MYH7 MYT1L NCK2 NDE1 NDEL1 NECAB1 NEFM NME7 NSRP1 NUP160 OLFM1 PCNT PCNX4 PGK1 PHF1 PIBF1 PIK3R3 PKN1 POLR3C PPFIA3 PPM1E PPP4R1 PPP5C PSPC1 QARS1 RABGAP1 RAD21 RANBP9 RASSF7 RBM41 RBSN RECK ROGDI RTRAF SH3BP5 SMARCD1 SMARCE1 SMC2 SMC3 SMC5 SMYD1 SNX6 SPARCL1 SPATC1L SPTBN4 SRGAP2 SRGAP3 STX11 STX18 SUFU SYBU SYNE1 TCAF1 TCEANC TFIP11 TIAM2 TRAF3IP1 TRAF4 TRIM29 TRIM68 TRIO TSGA10 TSPOAP1 TSR2 TTC23 TUBB TUBB2A UBASH3A UBASH3B USP2 UTRN XPNPEP1 YWHAE YWHAG YWHAQ YWHAZ ZNF124 ZNF197 ZNF365 ZNF76	6 interacting genes: AURKA CDC5L DISC1 DYRK1A PCNT TGFBR1
Entrez ID		27185	23040
HPRD ID		05553	14797
Ensembl ID		ENSG00000162946	ENSG00000186487
Uniprot IDs		C4P094 C4P096 C4P098 C4P0A4 C4P0A5 C4P0C4 C4P0C8 C4P0D0 C4P0D1 C4P0D2 C4P0D3 Q9NRI5	A0A2R8YF72 A0A3B3IRM3 A0A3B3IRX5 A0A3B3IS14 A0A3B3IS61 A0A3B3ISW5 Q9UL68
PDB IDs		5V4B
Enriched GO Terms of Interacting Partners?		Cytoskeleton Centrosome Microtubule Cytoplasm Microtubule-based Process Protein Binding Microtubule Cytoskeleton Organization Organelle Organization Cytosol Cytoskeleton-dependent Intracellular Transport Cytoskeleton Organization Microtubule-based Movement Microtubule Binding Transport Along Microtubule Microtubule-based Transport Organelle Localization Axo-dendritic Transport Identical Protein Binding Axonal Transport Kinesin Complex Regulation Of Microtubule-based Process Regulation Of Organelle Organization Retrograde Axonal Transport Cell Projection Organization Cell Projection Assembly Cytoskeletal Anchor Activity Regulation Of Cellular Component Organization Developmental Process Cilium Axon Cytoplasm Cell Projection Tau Protein Binding Plasma Membrane Bounded Cell Projection Assembly Ciliary Basal Body Ciliary Tip Organelle Assembly Microtubule Cytoskeleton Organization Involved In Mitosis Centriole Structural Constituent Of Cytoskeleton Microtubule Nucleation Nervous System Development Dihydropyrimidinase Activity Cilium Organization Positive Regulation Of Protein Localization To Cilium Negative Regulation Of Protein Phosphorylation Negative Regulation Of Protein Metabolic Process Synapse Ubiquitin Protein Ligase Binding Plasma Membrane Bounded Cell Projection Organization Establishment Of Organelle Localization	Microtubule Microtubule Organizing Center Protein Serine/threonine/tyrosine Kinase Activity Centrosome Protein Localization To Centrosome Plasma Membrane Bounded Cell Projection Organization Cilium Organization Peptidyl-serine Phosphorylation Protein Localization To Cytoskeleton Protein Phosphorylation Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Phosphorylation Cell Projection Organization Protein Serine/threonine Kinase Activity Histone H3T45 Kinase Activity Microtubule Cytoskeleton Organization Mitotic Spindle Organization Protein Kinase Activity Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Autophosphorylation Nervous System Development Regulation Of Signal Transduction By P53 Class Mediator Cytoskeleton Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Kinase Activity Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Oocyte Maturation Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone Centriole Spindle Organization Organelle Assembly Spindle Assembly Involved In Female Meiosis I Germinal Vesicle Histone H3S10 Kinase Activity Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Tight Junction Disassembly Positive Regulation Of Cell Growth Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process WD40-repeat Domain Binding Negative Regulation Of Heterochromatin Formation
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