INPP5J and EPS8

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		INPP5J	EPS8
Gene Name		inositol polyphosphate-5-phosphatase J	epidermal growth factor receptor pathway substrate 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane Growth Cone Dendritic Shaft	Cell Cortex Postsynaptic Density N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Growth Cone Vesicle Stereocilium Ruffle Membrane Extracellular Vesicular Exosome
	Molecular Function	Inositol-polyphosphate 5-phosphatase Activity SH3 Domain Binding Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity	Actin Binding SH3/SH2 Adaptor Activity Protein Binding Rac GTPase Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Negative Regulation Of Neuron Projection Development Negative Regulation Of Microtubule Polymerization Negative Regulation Of Peptidyl-serine Phosphorylation Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Dephosphorylation	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Cell Proliferation Adult Locomotory Behavior Regulation Of Cell Shape Positive Regulation Of Signal Transduction Exit From Mitosis Rac Protein Signal Transduction Regulation Of Actin Filament Length Actin Cytoskeleton Reorganization Dendritic Cell Migration Behavioral Response To Ethanol Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Actin Crosslink Formation Actin Polymerization-dependent Cell Motility
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Synthesis of IP2, IP, and Ins in the cytosol Metabolism of lipids and lipoproteins Phospholipid metabolism Inositol phosphate metabolism PI Metabolism
Drugs
Diseases
GWAS			Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		6 interactors: CDC23 DNAJA3 EPS8 GOLGA2 TRIM27 TRIM54	54 interactors: ABI1 ACTA1 ADAM22 AIMP2 ALDH7A1 ARMC1 BAIAP2 BCKDK BLOC1S6 BYSL C17orf59 C19orf25 C8orf33 CASK CCDC85B CSNK2B CTNNA3 CXCL2 DNALI1 DVL1 EGFR GOLGA8EP GRB2 GULP1 HNRNPC HOOK2 INPP5J ITGB1 ITGB3 ITGB5 MAP1LC3B MAP3K11 MRPL20 MYO15A NACC2 NFKB2 PCM1 PROSER2 RFXAP RUNX1T1 SCRN3 SF3B3 SHB SHC1 SLC27A4 SMARCE1 SOS1 SRC TDP2 TEX28 TPRN USP6NL XRCC6 ZZZ3
Entrez ID		27124	2059
HPRD ID		07573	02563
Ensembl ID		ENSG00000185133	ENSG00000151491
Uniprot IDs		Q15735	B4DX66 B4E3T6 Q12929
PDB IDs			2E8M
Enriched GO Terms of Interacting Partners?		Regulation Of Organelle Organization Negative Regulation Of Transferase Activity Regulation Of Cytoskeleton Organization Negative Regulation Of Protein Complex Disassembly Regulation Of Protein Depolymerization Regulation Of Protein Complex Disassembly Negative Regulation Of Immune Response Positive Regulation Of Protein Ubiquitination Negative Regulation Of Interleukin-2 Secretion Mitotic Cell Cycle Regulation Of Cellular Component Organization Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Catalytic Activity Actin Polymerization-dependent Cell Motility Negative Regulation Of Cellular Protein Metabolic Process Protein Polyubiquitination Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Metabolic Process Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Protein Ubiquitination Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Negative Regulation Of Calcium Ion Import Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Exit From Mitosis Activation-induced Cell Death Of T Cells Interferon-gamma Secretion Metaphase/anaphase Transition Of Mitotic Cell Cycle Positive Regulation Of Proteolysis Behavioral Response To Ethanol Actin Filament Organization Mitotic Nuclear Division Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of Protein Phosphorylation Regulation Of Cellular Component Size Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Complex Assembly Regulation Of Exit From Mitosis Mitochondrial DNA Replication Negative Regulation Of Proteolysis Cell Cycle Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Protein Processing Negative Regulation Of Immune System Process Organelle Organization Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Phosphorylation Regulation Of Actin Filament-based Process Regulation Of Protein Processing	Cell Differentiation Developmental Process Movement Of Cell Or Subcellular Component Multicellular Organismal Development System Development Anatomical Structure Development Cell Projection Morphogenesis Cell Part Morphogenesis Axonogenesis Axon Guidance Fc Receptor Signaling Pathway Axon Development Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Projection Organization Cell Morphogenesis Involved In Neuron Differentiation Anatomical Structure Morphogenesis Chemotaxis Neurogenesis Neuron Projection Development Immune Response-regulating Signaling Pathway Neuron Projection Morphogenesis Organelle Organization Positive Regulation Of Signal Transduction Cell Morphogenesis Leukocyte Migration Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Generation Of Neurons Cell Development Response To External Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Development Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Body Fluid Levels Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Hemostasis Regulation Of ERBB Signaling Pathway Nervous System Development Innate Immune Response Anatomical Structure Formation Involved In Morphogenesis Regulation Of Protein Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Phosphorylation Regulation Of Immune System Process Platelet Activation Response To Fibroblast Growth Factor
Tagcloud ?			adjacent breast cadherin cisplatin colony ectopic egf emt erk filopodia g418 healing invasive knockdown lentiviral mb231 mb468 mcf7 mda mmp9 mtt overexpressed possibly shrna stably transition vimentin weakly wound
Tagcloud (Difference) ?			adjacent breast cadherin cisplatin colony ectopic egf emt erk filopodia g418 healing invasive knockdown lentiviral mb231 mb468 mcf7 mda mmp9 mtt overexpressed possibly shrna stably transition vimentin weakly wound
Tagcloud (Intersection) ?