Wiki-Pi
About
Search
People
Updates
Search
INPP5J and EPS8
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
INPP5J
EPS8
Description
inositol polyphosphate-5-phosphatase J
EGFR pathway substrate 8, signaling adaptor
Image
No pdb structure
GO Annotations
Cellular Component
Ruffle
Cytoplasm
Cytosol
Plasma Membrane
Growth Cone
Neuron Projection
Dendritic Shaft
Plasma Membrane Bounded Cell Projection
Cytoplasm
Plasma Membrane
Brush Border
Cell Cortex
Postsynaptic Density
Membrane
NMDA Selective Glutamate Receptor Complex
Growth Cone
Vesicle
Stereocilium
Stereocilium Bundle
Stereocilium Tip
Ruffle Membrane
Cell Projection
Neuron Projection
Synapse
Extracellular Exosome
Glutamatergic Synapse
Molecular Function
Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity
Inositol-polyphosphate 5-phosphatase Activity
Protein Binding
Hydrolase Activity
Phosphatase Activity
SH3 Domain Binding
Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity
Inositol Trisphosphate Phosphatase Activity
Inositol-1,4,5-trisphosphate 5-phosphatase Activity
Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity
Actin Binding
Protein Binding
Small GTPase Binding
Biological Process
Phospholipid Metabolic Process
Phosphatidylinositol Biosynthetic Process
Negative Regulation Of Neuron Projection Development
Negative Regulation Of Microtubule Polymerization
Inositol Phosphate Metabolic Process
Glycerolipid Metabolic Process
Phosphatidylinositol Dephosphorylation
Rho Protein Signal Transduction
Adult Locomotory Behavior
Regulation Of Cell Shape
Exit From Mitosis
Rac Protein Signal Transduction
Actin Cytoskeleton Organization
Regulation Of Actin Filament Length
Regulation Of Rho Protein Signal Transduction
Dendritic Cell Migration
Behavioral Response To Ethanol
Barbed-end Actin Filament Capping
Actin Filament Bundle Assembly
Actin Crosslink Formation
Actin Polymerization-dependent Cell Motility
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Positive Regulation Of Ruffle Assembly
Cellular Response To Leukemia Inhibitory Factor
Pathways
Synthesis of PIPs at the plasma membrane
Synthesis of IP2, IP, and Ins in the cytosol
Synthesis of IP3 and IP4 in the cytosol
Sensory processing of sound by inner hair cells of the cochlea
Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases
GWAS
Fish- and plant-related diet (
32066663
)
Gut microbiota (beta diversity) (
27723756
)
Oily fish consumption (
32066663
)
Pork consumption (
32066663
)
Metabolite levels (
23823483
)
Protein quantitative trait loci (
18464913
)
Interacting Genes
18 interacting genes:
CDC23
CEP70
DNAJA3
EFHC2
EPS8
FXR2
GOLGA2
HSF2BP
MEOX1
MEOX2
PELI1
PICK1
PRKAR1B
PSME3
RINT1
TLE5
TRIM27
TRIM54
61 interacting genes:
ABI1
ACTA1
ADAM22
AIMP2
ALDH7A1
ARMC1
BAIAP2
BCKDK
BLOC1S6
BORCS6
BYSL
C19orf25
C6orf141
C8orf33
CASK
CBL
CCDC85B
CSNK2B
CTNNA3
CXCL2
DNALI1
DVL1
EGFR
GOLGA8EP
GRB2
GULP1
HNRNPC
HOOK2
INPP5J
ITGB1
ITGB3
ITGB5
ITSN2
MAP1LC3B
MAP3K11
MRPL20
MYO15A
NACC2
NFKB2
PCM1
PROSER2
RCAN3
RFXAP
RSPH14
RUNX1T1
SCRN3
SERPINA5
SF3B3
SHB
SHC1
SLC27A4
SMARCE1
SOS1
SRC
TDP2
TEX28
TPRN
USP6NL
XAGE2
XRCC6
ZZZ3
Entrez ID
27124
2059
HPRD ID
07573
02563
Ensembl ID
ENSG00000185133
ENSG00000151491
Uniprot IDs
B4DF95
B5MCL8
Q15735
B4E3T6
Q12929
PDB IDs
2E8M
7TZK
Enriched GO Terms of Interacting Partners
?
Somite Specification
Cytoplasm
Segment Specification
Somite Development
Regulation Of Cytoskeleton Organization
Epidermal Growth Factor Receptor Signaling Pathway
Filopodium
ERBB Signaling Pathway
Protein Tyrosine Kinase Activator Activity
Supramolecular Fiber Organization
Actin Filament Organization
Symbiont Entry Into Host Cell
Ephrin Receptor Binding
Actin Filament Bundle Organization
Actin Filament Bundle Assembly
Shc-EGFR Complex
Focal Adhesion
Enzyme-linked Receptor Protein Signaling Pathway
Wound Healing, Spreading Of Epidermal Cells
Phosphotyrosine Residue Binding
Biological Process Involved In Interaction With Host
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Developmental Process
Schwann Cell Development
Ruffle
SH3 Domain Binding
Cellular Response To Growth Factor Stimulus
Cellular Response To Platelet-derived Growth Factor Stimulus
Epidermal Growth Factor Binding
ERBB2 Signaling Pathway
Contractile Actin Filament Bundle Assembly
Stress Fiber Assembly
Response To Platelet-derived Growth Factor
Neuregulin Binding
Integrin Complex
C-X3-C Chemokine Binding
Cell Adhesion Mediated By Integrin
Response To Growth Factor
Wound Healing, Spreading Of Cells
Response To Activity
Neurotrophin TRKA Receptor Binding
Endocytosis
Insulin Receptor Signaling Pathway
Integrin Binding
Virus Receptor Activity
Insulin-like Growth Factor Receptor Signaling Pathway
Epidermal Growth Factor Receptor Binding
Heterotypic Cell-cell Adhesion
Actin-based Cell Projection
Cellular Developmental Process
Import Into Cell
Schaffer Collateral - CA1 Synapse
Ruffle Membrane
Integrin-mediated Signaling Pathway
Lamellipodium
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?