PELP1 and HIST2H2AC

Number of citations of the paper that reports this interaction (PMID 15456770)
18

Data Source:
BioGRID (pull down)

		PELP1	HIST2H2AC
Gene Name		proline, glutamate and leucine rich protein 1	histone cluster 2, H2ac
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane Transcriptionally Active Chromatin MLL1 Complex	Nucleosome Nucleus Extracellular Vesicular Exosome
	Molecular Function	Chromatin Binding Protein Binding Transcription Factor Binding Poly(A) RNA Binding	Molecular_function DNA Binding Protein Heterodimerization Activity
	Biological Process	Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Estrogen Stimulus	Biological_process
Pathways			RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: AR BAG6 BLOC1S1 CREBBP EP300 ESR1 ESR2 HGS HIST1H1A HIST1H4A HIST2H2AC HIST2H2BE NFKB1 NR3C1 RB1 SMAD9 SNCA SRC STAT3 TOM1L1	65 interactors: ANP32A ATXN7L3 BAP1 BARD1 BAZ1B BMI1 BRCA1 CDY1 CHFR COPRS CRP CTCFL CTDP1 DDB2 DNMT3L EIF2AK2 EP300 GATAD2A GATAD2B HAT1 HDAC2 HIST1H2BA HIST1H3A HIST1H4A HIST2H2BE HIST2H4A KAT2A KAT2B KAT5 KAT7 MSL2 MYSM1 NAP1L4 NCAPH NCL NPM1 PARP10 PBRM1 PELP1 PRMT5 PRMT7 RAG1 RBBP4 RCC1 RNF168 RNF2 RNF20 RNF8 SART3 SIRT7 SSRP1 TAF15 TAF1A TAF1B TCF20 TSPY1 TSSK6 UBC UBE2B UBR2 UIMC1 USP12 USP16 USP22 USP46
Entrez ID		27043	8338
HPRD ID		10144	09107
Ensembl ID		ENSG00000141456	ENSG00000184260
Uniprot IDs		B4DEX7 B4DR36 E7EV54 I3L3A8 Q8IZL8	Q16777
PDB IDs
Enriched GO Terms of Interacting Partners?		Intracellular Steroid Hormone Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Cellular Response To Organic Cyclic Compound Response To Organic Cyclic Compound Chromatin Organization Positive Regulation Of Gene Expression Response To Lipid Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Response To Steroid Hormone Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Carbohydrate Metabolic Process Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Uterus Development Cell Communication Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Regulation Of Gene Expression Cellular Response To Hormone Stimulus Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Chromatin Modification Intracellular Estrogen Receptor Signaling Pathway Reproductive Process Response To Hormone Cellular Response To Organic Substance Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Lipid Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signaling DNA-templated Transcription, Initiation Tube Development Steroid Hormone Mediated Signaling Pathway Organelle Organization Negative Regulation Of Signal Transduction N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Signaling Peptidyl-lysine Acetylation Hormone-mediated Signaling Pathway	Chromatin Organization Chromosome Organization Chromatin Modification Histone Modification Organelle Organization Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Modification Process Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Histone Ubiquitination Regulation Of Gene Expression, Epigenetic Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Cellular Protein Metabolic Process Gene Expression Chromatin Remodeling Regulation Of Metabolic Process Chromatin Silencing Cellular Metabolic Process DNA Packaging Nucleosome Organization Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Chromatin Assembly Or Disassembly Negative Regulation Of Nucleic Acid-templated Transcription Histone H2A Ubiquitination Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Histone Acetylation Nucleosome Assembly RNA Metabolic Process Protein-DNA Complex Assembly Internal Peptidyl-lysine Acetylation Negative Regulation Of Cellular Metabolic Process Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Negative Regulation Of Biosynthetic Process Cell Cycle Histone Deubiquitination Chromatin Assembly
Tagcloud ?		aacr autocrine branching cdk cdks coregulator demethylase deregulation facilitated gland glands hyper hyperbranching hyperplasia indicator kdm1 mammary mitogenic mmps mmtvrtta morphogenesis powerful precocious preneoplastic proto res tg tumorigenesis
Tagcloud (Difference) ?		aacr autocrine branching cdk cdks coregulator demethylase deregulation facilitated gland glands hyper hyperbranching hyperplasia indicator kdm1 mammary mitogenic mmps mmtvrtta morphogenesis powerful precocious preneoplastic proto res tg tumorigenesis
Tagcloud (Intersection) ?